461 research outputs found
THE HIDDEN POWER: A NEW PRACTICAL METHOD TO SAVE MONEY AND REACH GOALS IN PM
No full textThere is a striking power which is a hidden part of Project Management: it has been disregarded for ages.
The authors will show you how to find it out and especially on how to apply it in your daily life, to save money and get solid results in your PM activities.
In fact, the emerging discipline of Intercultural Project Management meets today’s urgent need for specific knowledge and experience when working with culturally diverse teams in joint global business and development projects.
Research studies show that managerial methods and behaviors are strongly influenced by each manager’s national and cultural background. The authors believe that the most flexible PM structural approach is that which moulds and shapes its components and real practices in what the authors call “Culture Sensitive Project Management”: cultural reflections cast a richer light on even the most advanced PM practices.
The result is a new project management approach which is truly able to adapt in order to maximize ways of reaching its goals, based both on the outcomes of research and on practical experience.
Culture can be a powerful way to create value and competitive advantage for individuals, teams and organizations, and it is possible to demonstrate in practice how to make this happen and provide cultural profitability for more advanced and successful project management
Arm Disability in Patients on Hemodialysis
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Arm Disability in Patients on Hemodialysis
Author(s): Toffola, ED (Toffola, Elena Dalla)1; Petrucci, L (Petrucci, Lucia); Mazzacane, B (Mazzacane, Bruno); Klersy, C (Klersy, Catherine)2; Villa, G (Villa, Giuseppe); Bossi, D (Bossi, Daniela)3; Bejor, M (Bejor, Maurizio)1
Source: DIALYSIS & TRANSPLANTATION Volume: 39 Issue: 3 Pages: 100-+ DOI: 10.1002/dat.20418 Published: MAR 2010
Times Cited: 0 (from Web of Science)
Cited References: 29 [ view related records ] Citation Map
Abstract: INTRODUCTION: End-stage renal disease patients on hemodialysis (HD) often present osteoarticular and musculoskeletal complications related both to chronic renal disease as well as to chronic dialysis. The aim of the present study was to assess the degree of upper-limb disability, and its determinants, in a group of patients on chronic HD to determine functional capacity and the need for rehabilitative treatment.
MATERIALS AND METHODS: We studied 97 HD patients (46 male, 51 female) with a mean age of 64.4 years, and 51 healthy controls. The Disabilities of the Arm, Shoulder, and Hand (DASH) Outcome Measure was used to clinically assess degree of disability as well as finger function and movement.
RESULTS: For study purposes, patients were divided into 3 groups according to the duration of dialysis: 10 years. The median DASH score was 9.5 (interquartile range [IQR]: 3.4-24.1) in the entire population. However, it differed significantly in the 3 dialysis groups with scores of 5.2 (IQR: 2.6-18.1), 14.7 (3.4-23.7), and 37.5 (9.5-73.3) in the 10 year groups, respectively (p < .001). Additionally, disability correlated with shoulder and hand pain and with finger stiffness. Moreover, patients on dialysis for more than 10 years were affected by pain involving several upper limb joints. All patients who worked had a DASH score lower than 20. The median DASH score was 2.6 (IQR: 0.9-5.2) in the control group.
CONCLUSION: Duration of dialysis is associated with progressive disability. Thus, early rehabilitation programs are recommended in patients who are expected to undergo long-term dialysi
Changes in GFR and plasma lipids durin renin-angiotensin system blockade by combination therapy enalapril plus valsartan in patients with diabetes and hypertension
No full textLA MODULAZIONE CULTURALE NEL PROJECT MANAGEMENT. L’IMPATTO DELLA CULTURA SULLA PROFITTABILITÀ DEI PROGETTI
No full textIl Project Management Interculturale offre modelli e strumenti operativi che permettono alle aziende di strutturare e migliorare la gestione di progetti in cui operano individui o gruppi appartenenti a culture diverse.
Studi recenti mostrano che modalità di agire e comportamenti manageriali sono fortemente influenzati dalla cultura nazionale dei singoli manager. Gli autori ritengono che un approccio flessibile alla gestione dei progetti debba essere capace di adattare e plasmare strumenti, processi e “practice” in quella che chiamano “Modulazione culturale nel Project Management”: la dimensione interculturale può quindi dimostrarsi capace di integrare e potenziare anche gli strumenti e i processi più avanzati di project ma- nagement.
Il risultato è un nuovo approccio, realmente in grado di adattarsi in modo da massimizzare la capacità di raggiungere i risultati voluti.
The Modular Intercultural Project Management
The emerging discipline of Intercultural Project Management meets today’s urgent need for specific know- ledge and experience when working with culturally diverse teams in joint global business and development projects.
Research studies show that managerial methods and behaviours are strongly influenced by each manager’s national and cultural background. The authors believe that the most flexible PM structural approach is the one that moulds and shapes its components and real practices in what the authors call “Cultural Sensitive Project Management” cultural reflections cast a richer light even to the most advanced PM practices.
The result is a new project management approach which is really capable of adapting itself so to maximize its capability of reaching its goals
Intercultural project management: how much is it culture free?
No full textProject Management is a well-defined structured activity.
When Project Management tools and practices are applied to international projects, are these tools stronger than culture? Or is culture overwriting them? If yes, how strong and expensive is the impact?
This was the starting question for our research within the emerging discipline of Intercultural Project Management which meets today’s urgent need for specific knowledge and experience when working with culturally diverse teams in joint global business and development projects.
The authors believe that the most flexible PM structural approach is that which moulds and shapes its components and real practices in what the authors call “Culture Sensitive Project Management”: cultural reflections cast a richer light on even the most advanced PM practices.
The result is a new project management approach which is truly able to adapt in order to maximize ways of reaching its goals, based both on the outcomes of research and on practical experience
Pembrolizumab with or without chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma: hypothesis coming from the subgroup analysis
No full textPembrolizumab in head and neck cancer
Harrington et al reported on the updated results of the phase III KEYNOTE-048 trial assessing pembrolizumab, an anti-PD-1 monoclonal antibody, with or without chemotherapy in recurrent/metastatic (RM) head and neck squamous cell carcinoma (HNSCC). A total of 882 recurrent/metastatic HNSCC patients were randomized 1:1:1 to pembrolizumab monotherapy (PM) (n = 301), pembrolizumab-chemotherapy (PC) (n = 281) or cetuximab-chemotherapy (n = 300).
we congratulate the study authors on this important contribution to the clinical management of such a highly complex disease. The subgroup analysis data suggests that there could be a population of patients achieving greater benefit from ICI in RM-HNSCC, thus giving a boost to clinical and translational research
Recension del Libro de Laura Bossi, Las fronteras de la muerte
No full textRecensiónLo que la autora se esfuerza por mostrar es el conjunto de dificultades éticas que implican la medicalización
de la muerte. La tesis principal defendida por Laura Bossi es la de la crítica de la progresiva medicalización de
la muerte, que gradualmente se ha inclinado hacia una lógica pragmática y utilitaria. Al final, terminó venciendo
el poder tecnocrático de la nueva biología del órgano que quiere, mediante los poderes de la tecnología,
borrar la muerte o, mejor, curarlaWhat the author strives to show is the set of ethical difficulties that involve the medicalization of death. The main thesis defended by Laura Bossi is the criticism of the progressive medicalization of death, which has gradually leaned towards a pragmatic and utilitarian logic. Finally, it ended up winning the technocratic power of the new biology of the organ that wants, through the powers of technology, erase death or, better, cure itinfo:eu-repo/semantics/publishedVersio
Surface plasmon resonance based on molecularly imprinted nanoparticles for the picomolar detection of the iron regulating hormone Hepcidin-25
No full textObjective: the study aimed at developing molecularly imprinted polymer nanoparticles (MIP NPs) for the recognition of Hepcidin-25 and at their further integration into an optical sensor based on surface plasmon resonance (SPR) suitable in the real time monitoring of the hormone. Materials and methods: MIP technique is a powerful mean to produce tailor made synthetic recognition sites. Here precipitation polymerization was exploited to produce a library of MIP NPs targeting the N terminus of the hormone Hepcidin-25. Biotinylated MIP NPs were immobilized onto a NeutrAvidinTM SPR sensor chip. The response of the MIP NP sensor to Hepcidin-25 was studied. Results: morphological analysis showed MIP NPs of 20-50 nm; MIP NPs exhibited high affinity and selectivity for the target analyte: low nanomolar Kds for the interaction with Hepcidin-25, but no interaction with the non-regulative Hepcidin-20. MIP NPs were integrated as recognition element in the SPR allowing the detection of Hepcidin-25 in 3 minutes. Linearity was observed with the logarithm of Hepcidin-25 concentration in the range 7.2-720 pM. The LOD was 5 pM. The response for Hepcidin-20 was limited. Hepcidin-25 determination in real serum samples spiked with known analyte concentrations was also attempted. Conclusion: the integration of MIP NPs to SPR allowed the determination of Hepcidin-25 at picomolar concentrations in short times outperforming the actual state of art. Optimization is still needed for real sample measurements in view of future clinical applications
Activities on PNS neural interfaces for the control of hand prostheses
No full textThe development of interfaces linking the human nervous system with artificial devices is an important area of research. Several groups are working on the development of devices able to restore sensory-motor function in subjects affected by neurological disorders, injuries or amputations. Neural electrodes implanted in peripheral nervous system, and in particular intrafascicular electrodes, seem to be a promising approach for the control of hand prosthesis thanks to the possibility to selectively access motor and sensory fibers for decoding motor commands and delivering sensory feedback. In this paper, activities on the use of PNS interfaces for the control of hand prosthesis are presented. In particular, the design and feasibility study of a self-opening neural interface is presented together with the decoding of ENG signals in one amputee to control a dexterous hand prosthesis
24-hour blood pressare profile and left ventricular anatomy and function in untreated hypertensives with and without microalbuminuria
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