1,721,382 research outputs found
Table_S2 - The Role of Hypoxia on the Neuronal Differentiation of Gingival Mesenchymal Stem Cells: A Transcriptional Study
No full textTable_S2 for The Role of Hypoxia on the Neuronal Differentiation of Gingival Mesenchymal Stem Cells: A Transcriptional Study by Agnese Gugliandolo, Francesca Diomede, Domenico Scionti, Placido Bramanti, Oriana Trubiani and Emanuela Mazzon in Cell Transplantation</p
Table_S1_(1) - The Role of Hypoxia on the Neuronal Differentiation of Gingival Mesenchymal Stem Cells: A Transcriptional Study
No full textTable_S1_(1) for The Role of Hypoxia on the Neuronal Differentiation of Gingival Mesenchymal Stem Cells: A Transcriptional Study by Agnese Gugliandolo, Francesca Diomede, Domenico Scionti, Placido Bramanti, Oriana Trubiani and Emanuela Mazzon in Cell Transplantation</p
sj-pdf-1-imr-10.1177_03000605221078715 - Supplemental material for Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report
No full textSupplemental material, sj-pdf-1-imr-10.1177_03000605221078715 for Neuropsychological implication in possible antibody-negative limbic encephalitis: a clinical case report by Viviana Lo Buono, Lilla Bonanno, Rosanna Palmeri, Simona Cammaroto, Rosa Morabito, Maria Cristina De Cola, Edoardo Sessa, Silvia Marino, Placido Bramanti and Francesco Corallo in Journal of International Medical Research</p
Is β-catenin neutralization cross-involved in the mechanisms mediated by natalizumab action?
No full textAberrant activation of Wnt/β-catenin signaling pathway is commonly associated to cancer development. However, molecular mechanisms controlling Wnt/β-catenin signaling pathway have been clarified only in part. Here, we show that β-catenin is differently modulated in patients with multiple sclerosis (MS), displaying that different pharmacological treatments used for clinical MS management cause different nuclear expression levels of β-catenin. Proteins extracted by peripheral blood mononuclear cells were assessed to evaluate the western blot expression levels of β-catenin. Analyzing our results, we realized that β-catenin is totally inhibited by Natalizumab and could have a role in MS management. This could offer new promising studies focused on the possible therapeutic control of β-catenin translocation
Molecular Mechanisms of Renal Cellular Nephrotoxicity due to Radiocontrast Media
Get PDFModern iodinated radiocontrast media are all based on the triiodinated benzene ring with various chemical modifications having been made over the last few decades in order to reduce their toxicity. However, CIN remains a problem especially in patients with pre-existing renal failure. In vitro studies have demonstrated that all RCM are cytotoxic. RCM administration in vivo may lead to a decrease in renal medullary oxygenation leading to the generation of reactive oxygen species that may cause harmful effects to renal tissue. In addition, endothelin and adenosine release and decreased nitric oxide levels may worsen the hypoxic milieu. In vitro cell culture studies together with sparse in vivo rat model data have shown that important cell signalling pathways are affected by RCM. In particular, the prosurvival and proproliferative kinases Akt and ERK1/2 have been shown to be dephosphorylated (deactivated), whilst proinflammatory/cell death molecules such as the p38 and JNK kinases and the transcription factor NF-κB may be activated by RCM, accompanied by activation of apoptotic mediators such as caspases. Increasing our knowledge of the mechanisms of RCM action may help to develop future therapies for CIN
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
A compact monitoring system for patients affected by neurodegenerative diseases
No full textIn this paper we report about the development of a compact monitoring system for people affected by neurodegenerative diseases as Parkinson and Alzheimer. The electronic interface is based on a Linkit ONE development board, and it is equipped with an array of up to four ADXL345 accelerometers. By considering the main symptoms of Parkinson subjects, it is possible to monitor tremors/movements and accidental falls of people wearing the system and to send data to a supervisor by Wi-Fi, Bluetooth and GSM connections. Furthermore, the geo-tagging functions, developed by means of a GPS feature, already equipped in the board, allow the monitoring of the movements and the position of Alzheimer subjects, avoiding the lost for memory failures
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