1,720,994 research outputs found
EFFECTS OF ANTIPSYCHOTIC TREATMENTS ON SERUM PROLACTINE LEVELS. A COMPARATIVE NATURALISTIC STUDY
No full textPsychosis in Patients in COVID-19-Related Quarantine: A Case Series
No full textWhile the long-term mental health effects of previous pandemics and related quarantines have been reported in the literature, research is scarce with regard to the first stages of this type of emergency situation. Sudden social isolation, societal restrictions, and virus-related fears may serve as precipitating factors in vulnerable individuals for many types of psychiatric conditions. The literature reports that individuals who are mentally vulnerable to environmental stressors can be deeply affected by quarantines,2 but no data are yet available regarding the collateral effects of the coronavirus disease 2019 (COVID-19) infection on the onset of acute psychosis.
We describe 3 clinical cases of patients admitted to the psychiatric ward of the Padua University Hospital, Padua, Italy, following the enactment of quarantine measures in the Veneto region of northeastern Italy. All 3 admissions occurred in a period of less than a week (March 20-25, 2020), starting 10 days after initiation of strict societal restrictions in the country
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Long-Acting Aripiprazole in the Management of Violence in Treatment Nonadherent Schizophrenia
No full textNo abstract availabl
A naturalistic study comparing two initial duloxetine dosing strategies in a clinical "real world" setting
No full textTo compare, in a "real world" setting. the efficacy and tolerability of two initial duloxetine starting doses: 30 mg once daily (q.d.) for I week, followed by escalation to, 60 mg q.d. versus 60 mg q.d. without titolation, evaluating expecially effects on sexual dysfunction. Methods. The sample is Constituted by outpatients meeting diagnostic criteria for mild-severe (HAMD(17) >= 24 and CGI-S >= 4) Major Depressive Episode as defined by DSM-IV-TR (Diagnostic and Statistic Manual for Mental Disorder. Fourth Edition-Text Revision). based oil the Structured Clinical Interview for DSM-IV-TR (Mini International Neuropsychiatric Interview, MINI),The study design planned all initial evaluation and 4 follow-up visits at each visit the following scales were administered: Hamilton Rating Scale for Depression (HAMD(17)) and Anxiety (HAMA), Clinical Global Impression Severity Scale (CGI-S) for severity evaluation and Arizona Sexual Experience Scale (ASEX) for Sexual disfunction evaluation. Results. Both of the groups showed 90% of response (>= 50% reduction in a patient's HAMD(17) total score from baseline) within 2 months of follow-up. 50%, of patients receiving a 30 mg q.d. starting dose achieved a HAMD(17) total score <= 7 versus 40% of 60 mg q.d. treating group. None showed relapses during the study After the first treatment month, the 60 mg q.d. receiving group showed a statistical significative amelioration of sexual function (Mann-Whitney test: p=0,02). Conclusions. Our naturalistic "real world" study results confirm previous duloxetine tolerability and efficacy findings suggesting a 60 mg q.d. after meal duloxetine somministration without titolation
Prevalence and Risk Factors for QTc Prolongation in Acute Psychiatric Hospitalization
No full textObjective: Prolongation of corrected QT (QTc) interval increases the risk of severe ventricular arrhythmias, in particular torsades de pointes. Patients with severe mental illness (SMI) represent a vulnerable population. This study aimed to measure the prevalence of QTc prolongation in inpatients with SMI and to identify risk factors for QTc prolongation. Methods: Demographic, clinical, anthropometric, laboratory, and electrocardiographic information was extracted from the electronic records of a cohort of patients hospitalized in a psychiatry inpatient unit between July 1, 2017, and July 22, 2019. The primary outcome was the estimation of prevalence of QTc prolongation. The secondary outcome was the identification of risk factors for QTc prolongation. Results: A total of 597 admissions were included. Only 1.4% had a QTc > 500 msec, while 11.6% had a QTc > 460 msec. The proportion of women with a QTc > 470 msec was 3.6% and men with a QTc > 450 msec was 7.3%. Several risk factors were individually associated with QTc prolongation. In the multivariate model explaining almost one-third of QTc variance, female sex (P = .04), older age (P = .011), heart rate (P < .001), systolic blood pressure (P = .042), potassium (P = .012), hemoglobin (P = .006), number of antipsychotics (P = .026), and treatment with clotiapine (P = .012) and clozapine (P = .003) were associated with QTc length. Several factors beyond pharmacologic treatment identify subjects at risk for QTc prolongation, and polypharmacotherapy does not seem to increase the risk of QTc prolongation. Conclusions: QTc prolongation was rare in this cohort of SMI inpatients. Most of the risk factors involved in QTc prolongation are unchangeable elements or linked to general medical conditions, and only a few are modifiable factors, including psychotropic treatment
Validation of the Italian version of the Northoff Catatonia Rating Scale
No full textPURPOSE: Catatonia is a psychomotor syndrome characterized by heterogeneous motor, behavioral and affective alterations, and, in some cases, neurovegetative abnormalities that can be life-threatening. Although the prevalence estimates of catatonia are 10-20% of the hospitalized population, its clinical recognition remains a challenge for most clinicians. Differently from other catatonia rating scales, the Northoff Catatonia Rating Scale (NCRS) also evaluates the affective alterations that patients experience during catatonia and thus provides a more inclusive assessment of the alterations associated with this condition. To provide clinicians with a valuable tool for diagnosis, we translated the NCRS in Italian and validated it on a sample of 52 hospitalized patients with psychiatric disorders. METHODS: An Italian version of the NCRS was prepared using the forward-backwards translation from English and administered to a sample of 52 in-patients (age 46.9±2.37 years). The inter-rater reliability, score correlations, internal coherence and decision statistics were computed. RESULTS: The inter-rater agreement was higher for the motor subscale (100% agreement) than for the behavioral (94%) or affective subscales (92.3%). The inter-rater agreement was 100% for the diagnosis of catatonia. The NCRS correctly identified all patients with catatonia according to DSM-5 (sensitivity= 100%) and had a specificity of 88.9%, and its subscale scores were highly inter-correlated. CONCLUSIONS: This validation shows that the NCRS yields a good accuracy in diagnosing catatonia and high inter-rater reliability. Moreover, the high correlation between its subscales supports the view that catatonia is a multi-faceted truly psycho-motor syndrome. In conclusion, the validation and Italian translation of the NCRS provides the clinicians with a helpful tool for diagnosing catatonia which is easy to use and assesses the full psychomotor complexity of the syndrome
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