2,183 research outputs found
Dataset of the AAC2 conformations in the c-, intermediate- and m-states obtained from free-energy simulations
No full textThe data reported herein are related to the article entitled: "The switching mechanism of the mitochondrial ADP/ATP carrier explored by free-energy landscapes" (Pietropaolo et al., 2016) [1].We report the coordinates of the ADP/ATP carrier (AAC2) in the presence and absence of adenine and guanine nucleotides in the c-, intermediate- and m-states obtained from the free-energy simulations and corresponding to the free-energy minima
Conformational preferences of the full chicken prion protein in solution and its differences with respect to mammals
No full textWe investigate the conformations of the full chicken prion protein
(ChPrP1-267) in solution at neutral pH with molecular dynamics
simulations. We focus on the persistence of its secondary structure motifs using a recently proposed protein chirality indicator [A. Pietropaolo et al. , Proteins 2008, 70, 667–677].
From this, we find a high rigidity of helix 2 (ChPrP178-195) and
of the hexarepeat domain, which is turn rich, and a plasticity of the short b-sheet, consistent with the available NMR structural
details. We also determine the extent of solvation for
each residue, revealing local minima for such structured regions.
These features hint at a possible origin of the high resistance
to proteolysis of the avian prion proteins and of its capability
in preventing the aggregation in comparison to mammals
Book Review of Keeping Time: An Introduction to Archival Best Practices for Music Librarians
No full textReview of a volume in the Music Library Association’s Basic Manual SeriesThis is the author's original version, accepted for publication in the forthcoming Volume 78, Number 1 (Spring-Summer 2015) of American Archivist
Preserving the electroacoustic music legacy: a case study of the SalMar Construction at the University of Illinois
No full textIn the summer of 2008 the Sousa Archives and Center for American Music at the University of Illinois at Urbana-Champaign acquired the papers of Salvatore Martirano (1927-1995), avant-garde composer, faculty member, and performer. This case study examines how the new electroacoustic compositional techniques present in Martirano's papers and his ground-breaking electronic music instrument, the Sal-Mar Construction, dramatically challenged the archivists to explore access and preservation practices for this unique cultural record. Context plays a key role in the preservation of electroacoustic compositions and instruments, considering that these tend to become ephemeral works of art once the composer ceases to maintain them in working order.This is the author's accepted manuscript of an article published in Notes, the Quarterly Journal of the Music Library Association. The published version is available at http://muse.jhu.edu/journals/notes/v068/68.1.cuervo.htmlPeer reviewe
Non-invasive neutron diffraction analysis of marbles from the "Edificio con Tre Esedre" in Villa Adriana
No full textRoman marble fragments from the Villa Adriana at Tivoli (Rome) have been characterised by neutron diffraction. This study aimed at distinguishing between different marble types on the basis of the mineral phase compositions and the crystallographic textures. It is demonstrated that on a multi-detector time-of-flight neutron diffractometer a quantitative bulk texture analysis can be performed on a stationary marble sample in a matter of minutes. This potentially allows investigating large sample series or bulky, intact marble objects in a completely non-destructive manner. The texture information, along with other structure details, can be used as characterising feature to address questions of attribution and restoration of archaeological marble objects
Not Just Sheet Music: Describing Print and Manuscript Music in Archives and Special Collections
No full textThe professional literature on archives and music librarianship in theUnited States only tangentially addresses the management of music archival records.Archives and special collections libraries often find print and manuscript music amongsttheir holdings, even if they are not music-specific repositories. Because printed musicmaterial is a proxy for the work and not the work itself, adequate description of thesematerials may require more granularity than archivists customarily provide. Existingstandards for archival description require more work before they will describe musicas easily as they describe text. The article offers descriptive examples for typicalmanifestations of musical works.Peer reviewe
The switching mechanism of the mitochondrial ADP/ATP carrier explored by free-energy landscapes
No full textThe ADP/ATP carrier (AAC) of mitochondria has been an early example for elucidating the transport mechanism alternating between the external (c-) and internal (m-) states (M. Klingenberg, Biochim. Biophys. Acta 1778 (2008) 1978-2021). An atomic resolution crystal structure of AAC is available only for the c-state featuring a three repeat transmembrane domain structure. Modeling of transport mechanism remained hypothetical for want of an atomic structure of the m-state. Previous molecular dynamics studies simulated the binding of ADP or ATP to the AAC remaining in the c-state. Here, a full description of the AAC switching from the c- to the m-state is reported using well-tempered metadynamics simulations. Free-energy landscapes of the entire translocation from the c- to the m-state, based on the gyration radii of the c- and m-gates and of the center of mass, were generated. The simulations revealed three free-energy basins attributed to the c-, intermediate- and m-states separated by activation barriers. These simulations were performed with the empty and with the ADP- and ATP-loaded AAC as well as with the poorly transported AMP and guanine nucleotides, showing in the free energy landscapes that ADP and ATP lowered the activation free-energy barriers more than the other substrates. Upon binding AMP and guanine nucleotides a deeper free-energy level stabilized the intermediate-state of the AAC2 hampering the transition to the m-state. The structures of the substrate binding sites in the different states are described producing a full picture of the translocation events in the AAC
The Things We Keep: Considerations for Appraisal of Archival Materials in Music Libraries
No full textThis article discusses archival appraisal in relationship the documentary evidence of music-making and the principles behind acquisition decisions in an archival setting. It also explores the concept of enduring value as it applies to music materials and formulates clear definitions of the distinct facets of archival appraisal. This is a crucial component to any archival management program that can contribute to the healthy growth of the institution and its collections. The author formulates foundational elements for archival practices that actively expand the scope of the documented musical heritage preserved in archives throughout the world and outlines strategies for collecting a well-rounded and inclusive view of history.Peer reviewe
El Tlacuache Núm. 437 (2010). 437 Año 10 (2010) octubre. El Tlacuache
No full textProcesos migratorios en la época prehispánica por Barbara Konieczna. -Los jornaleros asentados en Morelos: entre la inclusión y la exclusión en localidades rurales por Kim Sánchez, Adriana Saldaña. -Ñuu Savi en Jiutepec por Paola Marina Ávila Carranza
El Tlacuache Núm. 524 (2012). 524 Año 13 (2012) junio. El Tlacuache
No full textCelebración y creencias en torno a la imagen del Señor Santiago en Tenextepango, Morelos por Adriana Saldaña Ramírez, Sergio Ortíz Fernández, María Ortíz Rodríguez
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