1,721,239 research outputs found

    I portali nei complessi edilizi in pietra a secco della Puglia

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    La breve analisi si è articolata circoscrivendo il campo a quelle architetture rurali fatte di pietra che sono l'ele¬mento dominante del paesaggio agrario pugliese; ci ri¬feriamo in particolare ai portali e agli elementi che li compongono. Si è considerata un'analisi morfologica per la parte che viene guidata dagli aspetti materiali dell'ar¬chitettura, in quanto esito significativo di ogni altro aspetto, anche per ciò che tale materialità trascina: senso della memoria collettiva, simbolo, storia dei fatti, ne¬cessità e desideri di un corpo sociale, manifesti in quanto trasformazioni dell'ambiente fisico. Meglio, vorremmo riguardare gli aspetti della realtà capaci di produrre e consolidare forme nel campo di questo tipo di architet¬tura. Che cosa significa produrre delle forme e soprattutto quali sono le necessità che le producono? Tutto questo può portare ad identificare delle forme come modelli da imitare o da interpretare, oppure, come ele¬menti dalla cui composizione sia possibile produrne delle nuove. Ma guardare la questione morfologica dal punto di vi¬sta materiale significa anche prestare attenzione alla dif¬fusione nel mondo delle immagini architettoniche e al valore dell'immagine stessa, quale fondamento della "ri-produzione" contro la "produzione", evidente anche in questo tipo di architettura, mettendo in discussione la consistenza costitutiva della materia stessa. Ci riferiamo, quindi, a queste architetture sviluppate in particolari condizioni ambientali e climatiche, tali da giustificarne la realizzazione con blocchi di pietra calcarea compatta, sfruttando il principio costruttivo su cui si fon¬dava la "tholos". Ma le indagini volte alla classificazione e quindi alla comparazione degli elementi architettonici, partono certamente dalla catalogazione, sia pure sommaria, di que¬ste architetture rurali. Abbiamo, quindi, ad uso specifico della nostra analisi nell'intendimento di rendere più evidenti le differenze che nella realtà non sono così nette, distinto tra diversi gruppi, ciascuno dei quali appartiene ad una ben defi¬nita regione geografica, e i cui componenti presentano soluzioni comuni per la definizione statica e formale della porta

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    From the Structural and (Dys)Function of ATP Synthase to Deficiency in Age-Related Diseases

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    The ATP synthase is a mitochondrial inner membrane complex whose function is essential for cell bioenergy, being responsible for the conversion of ADP into ATP and playing a role in mitochondrial cristae morphology organization. The enzyme is composed of 18 protein subunits, 16 nuclear DNA (nDNA) encoded and two mitochondrial DNA (mtDNA) encoded, organized in two domains, FO and F1. Pathogenetic variants in genes encoding structural subunits or assembly factors are responsible for fatal human diseases. Emerging evidence also underlines the role of ATP-synthase in neurodegenerative diseases as Parkinson’s, Alzheimer’s, and motor neuron diseases such as Amyotrophic Lateral Sclerosis. Post-translational modification, epigenetic modulation of ATP gene expression and protein level, and the mechanism of mitochondrial transition pore have been deemed responsible for neuronal cell death in vivo and in vitro models for neurodegenerative diseases. In this review, we will explore ATP synthase assembly and function in physiological and pathological conditions by referring to the recent cryo-EM studies and by exploring human disease models

    Histochemical study of the mucins in the mucosa adjacent to colo-rectal carcinomas associated with single or multiple adenomatous polyps

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    Twelve surgical specimens from patients with carcinoma of the colon and rectum, associated with single or multiple adenomas, were studied. Scrapings from normal mucosa adjacent to the tumor or to the adenoma ('transitional') and from normal mucosa distant from the tumor were used for histochemical estimation of mucins. 'Transitional' mucosa showed increased sialomucins, in contrast to normal colonic mucosa where ulphomucins predominated

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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