1,724,799 research outputs found
Álvaro Pierri, guitarra (Uruguay)
No full textConcierto interpretado por el guitarrista Álvaro Pierri, Pierri es uno de los guitarristas clásicos de más renombre en la actualidad, es un maestro de su instrumento, de la talla de Andrés Segovia o de Julián Brea. Nació en Montevideo Uruguay en una familia de músicos, estudió con Abel Carlevaro y con el compositor Guido Santorsola y en el Instituto Nacional de Musicología de la Universidad de Uruguay
Replication Data for: The diffusion of mainstream and disinformation news on Twitter: the case of Italy and France
No full textThis dataset contains the ID of tweets shared in the period November-December 2019, and containing links to websites sharing disinformation and mainstream news in Italy and France.
Please refer to this paper for more details, and cite it if you use this dataset: Pierri F. The diffusion of mainstream and disinformation news on Twitter: the case of Italy and France", (2020) In Companion Proceedings of the The Web Conference 202
Replication Data for: HoaxItaly: a collection of Italian disinformation and fact-checking stories shared on Twitter in 2019
No full textReplication Data for: HoaxItaly: a collection of Italian disinformation and fact-checking stories shared on Twitter in 2019. Pierri, Artoni, Ceri
We release 1.2 million tweets shared during 2019 and containing links to thousands of news articles published on two classes of Italian outlets: (1) disinformation websites, i.e. outlets which have been repeatedly flagged by journalists and fact-checkers for producing low-credibility content such as false news, hoaxes, click-bait, misleading and hyper-partisan stories; (2) fact-checking websites which notably debunk and verify online news and claims
Mitochondrial carriers and related diseases
No full textSince the end of nineties numerous mitochondrial diseases have been found to be related to mutations in nuclear genes encoding mitochondrial carriers, a family of proteins that shuttle a variety of metabolites across the mitochondrial membrane. To date eleven disorders are known to be caused by defects of mitochondrial carriers. Mutations of mitochondrial carrier genes are responsible for carnitine/acylcarnitine carrier deficiency, ornithine carrier deficiency (HHH syndrome), aspartate/glutamate isoform 1 deficiency (global cerebral hypomyelination), aspartate/glutamate isoform 2 deficiency (CTLN2 and NICCD), amish microcephaly, neonatal myoclonic epilepsy, congenital sideroblastic anemia, PiC deficiency, ADP/ATP carrier isoform 1 deficiency and involved in neuropathy and bilateral striatal necrosis and adPEO (autosomal dominant progressive external ophthalmoplegia). We propose un updated overview of these diseases. We shall also discuss the role of missense mutations in impairing mitochondrial carrier function and the consequent severe damage to the mitochondrial matrix supply with substrates destined to specific metabolic pathways. Despite the substantial progress that has been made in our understanding of the molecular bases of mitochondrial carrier associated diseases, specific pharmacological therapies are not yet available. Current therapies are symptomatic and usually based on specific dietary measures. New therapeutic approaches are under investigation for some of these diseases.
For further reading
Palmieri F. (2008) Diseases caused by defects of mitochondrial carriers: a review. Biochim Biophys Acta; 1777:564-78.
Palmieri F, Pierri CL (2010) Structure and function of mitochondrial carriers - Role of the transmembrane helix P and G residues in the gating and transport mechanism. FEBS Lett. 584:1931-9.
Tessa A, Fiermonte G, Dionisi-Vici C, Paradies E, Baumgartner MR, Chien YH,Loguercio C, de Baulny HO, Nassogne MC, Schiff M, Deodato F, Parenti G, Rutledge SL, Vilaseca MA, Melone MA, Scarano G, Aldamiz-Echevarría L, Besley G, Walter J, Martinez-Hernandez E, Hernandez JM, Pierri CL, Palmieri F, Santorelli FM. (2009) Identification of novel mutations in the SLC25A15 gene in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome: a clinical, molecular, and functional study. Human Mutation; 30:741-8.
Wibom R, Lasorsa FM, Töhönen V, Barbaro M, Sterky FH, Kucinski T, Naess K, Jonsson M, Pierri CL, Palmieri F, Wedell A. (2009) AGC1 deficiency associated with global cerebral hypomyelination. N Engl J Med.; 361:489-95.
Iacobazzi V, Convertini P, Infantino V, Scarcia P, Todisco S, Palmieri F. (2009) Statins, fibrates and retinoic acid upregulate mitochondrial acylcarinitine carrier gene expression. Biochem Biophys Res Commun.; 388:643-7
Investigating Italian disinformation spreading on Twitter in the context of 2019 European elections
No full textWe provide two lists of ids of tweets containing a link to Italian disinformation articles and fact-checking posts, shared in the period from 07/01/2019 to 27/05/2019; we also provide the content of associated webpages in a ".pkl" format.
Tweets can be gathered using Twitter Search API.
Refer to the associated paper for more information on the data.
If you use this dataset please cite:
"Investigating Italian disinformation spreading on Twitter in the context of 2019 European elections" (2020) Pierri F., Artoni A., Ceri S. PLoS ON
Investigating Italian disinformation spreading on Twitter in the context of 2019 European elections
No full textWe provide two lists of ids of tweets containing a link to Italian disinformation articles and fact-checking posts, shared in the period from 07/01/2019 to 27/05/2019; we also provide the content of associated webpages in a ".pkl" format.
Tweets can be gathered using Twitter Search API.
Refer to the associated paper for more information on the data.
If you use this dataset please cite:
"Investigating Italian disinformation spreading on Twitter in the context of 2019 European elections" (2020) Pierri F., Artoni A., Ceri S. PLoS ON
ISFULAC: Integrating socioeconomic factors and urban configurations in 18 Latin American cities
No full textThis dataset supplements the scientific article by Pierri-Daunt and Siedentop (2025), which introduces a classification system for 18 cities in Latin America and the Caribbean (LAC), encompassing a total of 253 municipalities. It provides the dataset used for the classification, along with the cluster numbers assigned to each group.
The dataset combines various socioeconomic, demographic, and spatial characteristics of built-up areas at two scales of analysis: the city–regional scale (Data.city.origin.3HC.csv) and the municipal scale (Data.munic.orig.3HC.csv). Its purpose is to classify, compare, and identify cities and municipalities with similar typological features.
A complete description of the methodology and data sources can be found in README.txt and dataset_description_sources_information_PIerriDaunt_ISFULAC.pdf.
We identified three primary categories. City scale: Cluster 1 (saturated and well-serviced cities); Cluster 2 (vulnerabilized and dense cities); Cluster 3 (low-service and fragmented cities); Municipal scale: Cluster 1 (central, infilling, dense and well-serviced municipalities); Cluster 2 (building up at the edge and vulnerabilized); Cluster 3 (expanding, marginalized and low-density)
Transport mechanism of mitochondrial carriers
No full textThe inner mitochondrial membrane contains a superfamily of proteins, called mitochondrial carriers (MCs), which transport several metabolites into and out of the mitochondrial matrix. As observed in the ADP/ATP carrier structure, crystallized in complex with its powerful inhibitor carboxyatractyloside, the main structural fold of the MCs consists of a barrel of six transmembrane α-helices whose charged surfaces form the wall of a water-filled cavity. Multiple sequence alignment and 3D comparative models of mitochondrial carriers of known function have recently allowed the identification of i) a similarly located binding site located in the carrier cavity, ii) two ion pair networks or gates that are on the matrix or the cytosolic side of the carrier molecules, and iii) two Pro-Gly levels above and below the substrate binding site. As a result of the substrate–protein interactions, ‘hinged helix movements’ consisting of a tilt of the entire helical segments and a kink/swivel of the helical termini at the level of their Pro and Gly have been proposed to be fundamental for the alternative opening and closure of the gates on the matrix or the cytosolic side and thus for the translocation mechanism. The key role of residues of the binding site, gates and Pro-Gly levels in substrate translocation is supported by the localization of most missense mutations found in patients affected by diseases associated to mitochondrial carriers.
References
Klingenberg M (2007 ) Transport viewed as a catalytic process. Biochimie. 89:1042-8.
Palmieri F (2008) Diseases caused by defects of mitochondrial carriers: a review. Biochim Biophys Acta 1777: 564-57
Palmieri F, Pierri CL (2010) Structure and function of mitochondrial carriers - Role of the transmembrane helix P and G residues in the gating and transport mechanism. FEBS Lett. 584:1931-9
Pebay-Peyroula E, Dahout-Gonzalez C, Kahn R, Trézéguet V, Lauquin GJ, Brandolin G. (2003) Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside. Nature. 426:39-44
Robinson AJ, Kunji ER. (2006) Mitochondrial carriers in the cytoplasmic state have a common substrate binding site. Proc Natl Acad Sci U S A. 103:2617-22
Robinson AJ, Overy C, Kunji ER. (2008) The mechanism of transport by mitochondrial carriers based on analysis of symmetry. Proc Natl Acad Sci U S A. 105:17766-71
Wibom R, Lasorsa F, Töhönen V, Barbaro M, Sterky F, Kucinski T, Naess K, Jonsson M, Pierri CL, Palmieri F, Wedell A (2009) AGC1 deficiency associated with global cerebral hypomyelination. N Engl J Med 361: 489-49
La función del concepto de requisito en Confessio Philosophi : Una delgada línea entre el principio de razón suficiente y el necesitarismo metafísico
No full textFil: Pierri, Andrea. UNLP
Forecasting Probability of Bankruptcy from unbalanced data
No full textWhen analysing the determinants of bankruptcy of small and medium enterprises, one of the most common problems is that of unbalanced data, as very often the event under study happens in only a small percentage of cases. The aim of this paper is to explore three different statistical methods of coping with unbalanced data and to identify which of these has the greatest predictive capability in the context of the bankrupcty event.
The dataset is composed of all firms which were active in Tuscany in 2006. For each of them we have a five-year series of balance sheet indicators. Bankruptcy is represented by their legal status at May 2010. We focused on some indicators previously identified as predictors of the state of bankruptcy (Pierri 2013; Pierri, Burchi and Stanghellini 2013) and we tested the same model using the following three methods: logistic regression for matched case-control studies, logistic regression for a random balanced data sample, logistic regression for a sample balanced by ROSE (Random OverSampling Examples, Menardi and Torelli 2014). We built a training sample to develop the models and a hold-out sample to compare their discriminatory ability through ROC curves
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