88 research outputs found
Protein synthesis and gene expression in transplanted and postischemic livers
No full textThe expression of some genes has been comparatively studied in transplanted rat liver and in liver reperfused after ischemia in situ. Experiments on protein synthesis by tissue slices from cold-stored or transplanted livers show that rat livers that retain a good capacity for protein synthesis during storage undergo a profound impairment in the capacity for protein synthesis during the first hours after transplantation. This recovers in the following hours. There is never any indication of synthesis of stress proteins, and of hsp 70 in particular. The steady-state level of mRNAs for albumin, transferrin, and beta-actin, which are well expressed in reperfused postischemic livers in vivo, are reduced early after transplantation and recover only many hours later. Run-on analysis shows that an early defect in transcription and a partial recovery of this process later on are responsible for these changes. The steady-state levels of the same mRNAs are well maintained in donor livers preserved in University of Wisconsin solution for at least 12 hr, and less satisfactorily in Euro-Collins solution. Results of run-on analysis parallel the data on mRNA levels. The behavior of these mRNAs is, therefore, clearly different in reperfused and transplanted liver
Effectiveness of continuous prophylaxis of recurrent HBV hepatitis after liver transplantation
No full textDuodenal gross and microscopic findings after spleno-duodeno-pancreatic allotransplantation in the pig
No full textOrthotopic liver-small bowel allotransplantation: results of an experimental study in the pig
No full textExecutive functions in a virtual world: A study in parkinson's disease
No full textIn Parkinson's disease executive functions are altered. We used a Virtual Reality version of theMultiple Errand Test in order to evaluate decision-making ability in 12 patients and 14 controls. Patients with Parkinson's disease, even if not-demented, showed strategies full of errors, suggesting that impulse control disorder, very frequent in course of disease, could precede cognitive dysfunctions
Binaural CASA algorithm for speech source localization: Advancements in noisy and reverberant situations
No full textIn this thesis a binaural CASA localization algorithm is developed for the implementation in a binaural hearing aid with downstream speech enhancement. Two binaural CASA localization algorithms, based on the Albani model, are proposed to enhance the localization performance in noisy and reverberant acoustic environments. The Albani model is extended with a zero-lag interaural coherence (IC) time window pre-selection, detection of multiple sources per time-window, coincidence detection between interaural level and time differences (ILD and ITD) and a lagged time window comparison, in the proposed extended Albani algorithm. A further addition to the proposed extended Albani algorithm with a binaural cue selector based on an inhibition process, is proposed in the extended Albani algorithm with cue selection by inhibition. Performed simulations show that the extended Albani algorithm performs the best in noisy situations up to a SNR level of -12 dB and the extended Albani algorithm with cue selection by inhibition performs the best in reverberant situations up to a reverberation time of 2.0 s. These proposed localization algorithms show a better performance than the present known CASA methods in both noise and reverberation.Laboratory for Acoustical Imaging and Sound ControlImaging Science & TechnologyApplied Science
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