1,721,018 research outputs found
Sleep disturbance in obsessive-compulsive disorder
No full textIntroduction: Obsessive-Compulsive Disorder (OCD) is a common, chronic disorder which results in marked distress and impairment of social and occupational functioning. Sleep disturbance often accompanies mental disorders, but there have been few studies of sleep disturbance in OCD. These have produced contradictory findings, with some reporting sleep disruption, and others a normal sleep pattern. The aim of the present study is to examine sleep patterns in OCD, to establish the frequency of the different types of insomnia (early, middle and late insomnia) in a sample of patients with OCD. The study also intends to determine whether the presence of a comorbid mood disorder influence frequency and type of insomnia. Methods: all patients with a primary diagnosis of OCD (according to DSM-IV criteria) consecutively referred to the Mood and Anxiety Disorder Unit, Department of Neuroscience, University of Turin, from January 2003 to June 2008, were recruited. Frequency and severity of the different types of insomnia were evaluated on the basis of the Hamilton Depression Rating Scale (HDRS) specific items score (item 4-5-6). A statistical comparison between OCD patients with and without insomnia was performed to examine whether there was any difference in clinical features. Then a statistical comparison between patients with and without depressive comorbidity was performed to examine whether there was any difference in prevalence and type of insomnia. Results: The sample included 315 OCD patients. More than a half of the sample suffered from any type of insomnia. The most frequent type of insomnia was early insomnia (about 44,8%). We didn't find a positive correlation between the severity measured with total Y-BOCS score or obsessions and compulsions sub-score clinical and socio-demographic features and insomnia. The presence of any comorbid depressive disorder increased the frequency of insomnia. Conclusions: Insomnia, especially the early one, is a common symptom in OCD patients with or without comorbid depressive disorders. Late insomnia is typical of OCD with comorbid major depression. © 2010 Nova Science Publishers, Inc. All rights reserved
Pessina, Enrico
No full textLa biografia di Enrico Pessina, uno dei più autorevoli penalisti nell'Italia dell'Ottocento, costituisce la traccia che consente di ricostruire un profilo di sintesi della scienza penale italiana tra il Risorgimento e il primo cinquantennio post-unitario. L'analisi muove dalla formazione filosofica e umanistica dell'insigne giurista, per occuparsi quindi del suo impegno politico, della visione costituzionalistica e dell'intersezione tra quest'ultima e l'ottica penalistica, della carriera accademica e forense. Esponente di spicco della scuola classica o liberale, ministro e artefice non secondario del codice Zanardelli, Pessina seppe aprirsi alle contaminazioni positivistiche, incarnando nel senso più profondo e in perfetta sintonia con la tradizione culturale meridionale la concezione "vichiana" del diritto come regola di condotta anzitutto morale
Management of treatment resistant obsessive-compulsive disorder. Algorithms for pharmacotherapy
No full textTreatment resistant OCD subjects, defined as those patients who undergo an adequate trial of SRI (clomipramine or SSRI) and do not respond or show unsatisfactory results, account for 40-50% of all patients. Once the appropriateness of the trial has been assessed, several options exist for the clinicians. If clomipramine or citalopram have been used, an appropriate strategy consists in giving the same drug intravenously. Double-blind studies exist on the efficacy of clomipramine IV, while data are missing for citalopram. Another option that should be considered first, although data are scarce, is the addition of a cognitive behavioral therapy, when available, in the forms of exposure and response prevention. When such options are not suitable or available, augmentation of the ongoing SRI with another compound represents the preferable strategy. Double-blind, placebo-controlled studies have shown the efficacy of adding pindolol (7.5 mg/d), risperidone (2 mg/d) and olanzapine (5-10 mg/d). Other agents have been proposed, but data emerging from double-blind studies were negative or contradictory. Another option available is switching from CMI to SSRI, or vice versa, or from SSRI to SSRI. Data regarding such treatment strategy, however, are highly preliminary, based on a couple of open label reports and on studies performed in treatment resistant depression. An unresolved question is whether augmentation should be preferred to switching. No data exist in OCD; a practical approach would suggest augmentation first, considering that response should be obtained faster than by switching compound. When all the available and effective strategies prove uneffective, clinicians should consider switching the patient to other compounds in monotherapy, such as venlafaxine, sumatriptan, inositol, although research is strongly needed before conclusions on the efficacy of such compounds can be drawn
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Impact of comorbid obsessive-compulsive disorder on suicidality in patients with bipolar disorder
Full text linkThis study evaluated the impact of comorbid OCD on suicide attempt risk and suicide methods in 990 patients with main diagnosis of BD. Two hundred and one patients (20.3%) had lifetime comorbid OCD. No significant differences were found comparing rates of lifetime suicide attempts between patients with or without comorbid OCD (30.3% vs 24.6%). In the subgroup of patients with concomitant OCD more subjects performed suicide attempts with violent methods (48.3% vs 28.7%). Therefore, our results suggest a correlation between comorbid OCD and violent suicide attempts. This finding is worthy of interest and deserves to be explored by further studies
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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