1,721,118 research outputs found
Il «buon costume» come limite ai diritti: prospettive e problematiche
No full textThis doctoral thesis concerns the concept of «good mores» as a limitation to constitutional rights. The goal of
this research is to devise a definition of this concept that a secularized and pluralist society can accept.
In the first part of the thesis I have examined the «good mores» within Italian legal system. I have singled out
the legal sources that refer to «good mores», or to similar notions, and I have studied how these concepts
live in the jurisprudence and in doctrinal opinions. In the second part of the thesis I have analyzed the «good
mores» in a transnational context, and I took into account this clause in the European dimension and, in a
comparative perspective, in a foreign legal system, namely that of U.S.A. In the last part of the work I
attempted a definition of the «good mores». Since this concept has a content that belongs to the sphere of
ethics and values, I held that the source of shared values in a liberal-democratic society might be its
Constitution, and, within a pluralist Constitution, there might be an overlapping consensus on the value of
human dignity. Therefore, I examined the possibility to link the «good mores» to human dignity, and I
explored the consequences of that interpretive solution with regard to fundamental rights of the individual.
Sigma-2 receptor,method of screening of specific ligands and use of the same in diagnostic or therapeutic methods
No full textPREPARATION OF 1-(HETERO)ARYL-4-(CONDENSED THIAZOL-2-YLALKYL)PIPERAZINEDERIVATIVES FOR TREATMENT OF 5-HT1A- RECEPTOR MEDIATED DISORDERS
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders
No full textSince its discovery in the 1940s in serum, the mammalian intestinal mucosa, and in the central nervous
system, serotonin (5-HT) has been shown to be involved in virtually all cognitive and behavioral human
functions, and alterations in its neurochemistry have been implicated in the etiology of a plethora of
neuropsychiatric disorders. The cloning of 5-HT receptor subtypes has been of importance in enabling them to
be classified as specific protein molecules encoded by specific genes. The 5-HT7 receptor is the most recently
classified member of the serotonin receptor family. Since its identification, it has been the subject of intense
research efforts driven by its presence in functionally relevant regions of the brain. The availability of some
selective antagonists and agonists, in combination with genetically modified mice lacking the 5-HT7 receptor,
has allowed for a better understanding of the pathophysiological role of this receptor. This paper reviews data
on localization and pharmacological properties of the 5-HT7 receptor, and summarizes the results of
structure-activity relationship studies aimed at the discovery of selective 5-HT7 receptor ligands. Additionally,
an overview of the potential therapeutic applications of 5-HT7 receptor agonists and antagonists in central
nervous system disorders is presented
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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