1,721,110 research outputs found
Transplantation of peripheral blood stem cells mobilized by haematopoietic growth factors in childhood.
No full textPeripheral blood stem cells (PBSC), mobilised by means of haematopoietic growth factors (HGF) with or without chemotherapy, are being used routinely for autologous rescue after high-dose chemo-radiotherapy in paediatric patients with lymphoma and selected solid tumours because of the ease of collection and the accelerated kinetics of neutrophil and platelet engraftment as compared with bone marrow cells. Recent reports indicated that HGF-mobilised PBSC can also be employed in childhood as an alternative to bone marrow allograft when the donor is an adult or with the aim of reversing graft failure in patients who were previously given a marrow allograft. Notwithstanding this wide use of PBSC, several biological and clinical questions of crucial relevance are still unsolved. In this article, we will analyse: (1) the optimal timing for PBSC collection after cytokine-based mobilising regimens; (2) the variables affecting the yield of peripheral blood progenitors; (3) the minimum threshold and the optimal number of PBSC that should be infused for autologous and allogeneic transplant, respectively; (4) the biological mechanisms underlying mobilisation of haematopoietic stem cells into circulation; (5) the incidence of graft-versus-host disease and the biological characteristics of donor lymphocytes in patients given allogeneic transplant of PBSC; and (6) the most relevant peculiarities in the kinetics of immune recovery of patients given allogeneic transplant of PBSC, as compared to bone marrow transplant recipients
Syndepositional fractures and architecture of the lastoni di formin carbonate platform: Insights from virtual outcrop models and field studies
No full textThe recent rapid improvement of Unmanned Aerial Vehicles, together with advances in photogrammetry and Structure from Motion techniques, have enhanced the role of Digital Outcrop Models in many field of geology, due to the possibility to obtain quantitative information from large and inaccessible areas. In this study we integrated Digital Outcrop Modeling techniques and field survey to investigate the architecture of the Middle Triassic platform of Lastoni di Formin. (Italian Dolomites). The research highlighted the presence of two superimposed carbonate bodies. The lower unit (Cassian I) is dominated by low-angle clinoforms dipping north-northeastward and prograding over the basinal San Cassiano Fm. The upper unit (Cassian II) is characterized by a thick sequence of peritidal cycles connected northward to another generation of clinoforms. The inner platform beds of the upper unit display a lateral thickening that is particularly evident near the shelf break, and that has been interpreted as due to the increased subsidence and the consequent down-to-basin tilting of the outermost part of the platform. Moreover, the structural analysis performed on the Digital Outcrop Models and supported by field observations, highlighted the presence of an early generation of faults and joints that indicate an early gravitational deformation of the buildup, possibly caused by the platform progradation and compaction-induced subsidence of the San Cassiano basinal deposits. These WNW-ESE synsedimentary structures are formed by normal faults and extensional joints that are oriented nearly perpendicular to the direction of progradation of the carbonate platform
Reliability and uncertainties of the analysis of an unstable rock slope performed on RPAS digital outcrop models: The case of the gallivaggio landslide (Western Alps, Italy)
Full text linkA stability investigation based on Digital Outcrop Models (DOMs) acquired in emergency conditions by photogrammetric surveys based on Remote Piloted Aerial System (RPAS) was conducted on an unstable rock slope near Gallivaggio (Western Alps, Italy). The predicted mechanism of failure and volume of the unstable portion of the slope were successively verified on the DOMs acquired after the rockfall that effectively collapsed the May 29th, 2018. The comparison of the pre-and post-landslide 3D models shows that the estimated mode of failure was substantially correct. At the same time, the predicted volume of rock involved in the landslide was overestimated by around 10%. To verify if this error was due to the limited accuracy of the models georeferenced in emergency considering only the Global Navigation Satellite System/Inertial Measurement Unit (GNSS/IMU)-information of RPAS, several Ground Control Points (GCPs) were acquired after the failure. The analyses indicate that the instrumental error in the volume calculation due to the direct-georeferencing method is only of the 1.7%. In contrast, the significant part is due to the geological uncertainty in the reconstruction of the real irregular geometry of the invisible part of the failure surface. The results, however, confirm the satisfying relative accuracy of the direct-georeferenced DOMs, compatible with most geological and geoengineering purposes
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Peripheral blood stem cell collection from healthy donors for allogeneic transplantation
No full textThere is great interest in the use of peripheral blood stem cells (PBSC) for allogeneic transplantation, based on the good results seen with autologous PBSC infusion. Reasonable caution exists regarding the use of allogeneic PBSC for transplantation because of donor toxicities due to rhG-CSF administration and the risk of graft-versus-host-disease (GVHD) in the recipient because of the large number of T-cell infused. We present preliminary data on allogeneic PBSC collections and transplantation in ten patients affected by advanced leukemia (eight patients), severe aplastic anemia (one patient) and sickle cell anemia (one patient). Seven donors were HLA-identical siblings, while the other three were mismatched for three, two and one locus, respectively. All donors received rhG-CSF at a dose of 12 micrograms/kg for a mean of 5 days. Leukaphereses were performed with the aim of collecting a minimum of 5 x 10(6)/kg (recipient's weight) CD 34+ cells. Collection timing was determined by monitoring CD 34+ cells in the donor's peripheral blood from the second day of rhG-CSF therapy. The PBSC collections yielded a mean of 10.05 x 10(8) MNCs/kg and of 10.48 x 10(6) CD 34+ cells/kg (recipient's weight). PBSC were immediately infused after collection in patients given myeloablative therapy. Engraftment was observed in each patient at a mean of 13.2 days for an absolute neutrophil count (ANC) more than 0.5 x 10(9)/L and of 26.5 days for a platelet count of more than 20 x 10(9)/L. Eight patients experienced no or moderate acute GVHD, whereas two patients died of grade 4 GVHD, notwithstanding GVHD prophylaxis with cyclosporine and prednisone. Two other patients died of viral and fungal infections, respectively, despite prophylaxis. The remaining six patients are alive between 58 and 430 days after transplant. Our results document that allogeneic PBSC are capable of engraftment after a myeloablative regimen. Controlled trials are necessary to compare the potential benefits of this approach with the results obtained in allogeneic bone marrow transplantation
Analysis by UAV digital photogrammetry of folds and related fractures in the monte antola flysch formation (Ponte organasco, Italy)
No full textThe deformation structures (folds and fractures) affecting Monte Antola flysch formation in the area of Ponte Organasco (Northern Apennines-Italy) were analyzed by Unmanned Aerial Vehicle Digital Photogrammetry (UAVDP). This technique allowed the realization of Digital Outcrop Models (DOMs) interpreted in a stereoscopic environment by collecting a large number of digital structural measures (strata, fractures and successively fold axes and axial planes). In particular, by UAVDP was possible to analyze the relationships between folds and fractures all along the study structures. The structural analysis revealed the presence of a series of NE-vergent folds characterized by a typical Apenninic trend and affected by four main sets of fractures. Fractures are always sub-orthogonal to the bedding, maintains constant angular relationships with the bedding and seems linked to the folding deformation. The study shows that the UAVDP technique can overcome the main limitations of field structural analysis such as the scarce presence and the inaccessibility (total or partial) of rock outcrops and allows for acquiring images of rock outcrops at a detailed scale from user-inaccessible positions and different points of view and analyze inaccessible parts of outcrops
Detection and geometric characterization of rock mass discontinuities using a 3D high-resolution digital outcrop model generated from RPAS imagery – Ormea rock slope, Italy
Full text linkThe use of a remotely piloted aircraft system (RPAS) and digital photogrammetry is valuable for the detection of discontinuities in areas where field mapping and terrestrial photogrammetry or laser scanner surveys cannot be employed because the slope is unsafe, inaccessible, or characterized by a complex geometry with areas not visible from the ground. Using the Structure-from-Motion method, the acquired images can be used to create a 3D texturized digital outcrop model (TDOM) and a detailed point cloud representing the rock outcrop. Discontinuity orientations in a complex rock outcrop in Italy were mapped in the field using a geological compass and by manual and automated techniques using a TDOM and point cloud generated from RPAS imagery. There was a good agreement between the field measurements and manual mapping in the TDOM. Semi-automated discontinuity mapping using the point cloud was performed using the DSE, qFacet FM, and qFacet KD-tree methods applied to the same 3D model. Significant discrepancies were found between the semi-automatic and manual methods. In particular, the automatic methods did not adequately detect discontinuities that are perpendicular to the slope face (bedding planes in the case study). These differences in detection of discontinuities can adversely influence the kinematic analysis of potential rock slope failure mechanisms. We use the case study to demonstrate a workflow that can accurately map discontinuities with results comparable to field measurements. The combined use of TDOM and RPAS dramatically increases the discontinuity data because RPAS can supply a good coverage of inaccessible or hidden portions of the slope and TDOM is a powerful representation of the reality that can be used to map discontinuity orientations including those that are oriented perpendicular to the slope
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