1,721,009 research outputs found
Why should sarcopenic obesity be included in a routine assessment during weight-management programmes?
Full text linkNuovo sostituto dermico e sua applicazione terapeutica
No full textIl prodotto oggetto del brevetto è costituito da:a)cellule staminali/stromali multipotenti autologhe ottenute da microaspirazione di tessuto adiposo sottocutaneo e in grado di differenziare nelle cellule che costituiscono il derma umano e di produrre matrice connettivale; b) da una matrice biocompatibile tridimensionale.Le cellule stromali autologhe multipotenti sono seminate nello scaffold dopo un periodo di selezione-coltura in vitro. Questo prodotto è destinato alle strutture sanitarie specialistiche con le seguenti indicazioni terapeutiche: lesioni con perdita di tessuti molli di varia eziologia, sia di natura acuta (traumatiche, ustioni, esiti post-chirurgici) sia di natura cronica (ferite da pressione, ulcere vascolari, ulcere del piede diabetico)
Emx2 developmental expression in the primordia of the reproductive and excretory systems
No full textThe development of the urogenital system hasalways attracted many investigators owing to the peculiaraspects of the embryology of the reproductive and excretoryorgans and to the high number of congenital anomaliesrelated to these structures. It is remarkable becauseof the common origin of the kidneys, gonads, and genitaltracts from the intermediate mesoderm and because differentiation of these organs involves extensive mesenchymeto epithelium transition. Our knowledge about themolecular mechanisms controlling the differentiation ofthese diverse structures from the same precursor has takenadvantage of gene expression data and gene-targetingexperiments using genes with a specific expression patternin the urogenital system. A more detailed functionin kidney development has been postulated for transcriptionfactors such as WT-1, Pax-2 or other molecules suchas glial cell line-derived neurotrophic factor (GDNF),Wnt-4, c-ret. In the present work we have described theexpression pattern of the homeobox-containing geneEmx2 during the development of the urogenital system inmouse embryos. We have found that Emx2 is expressedin the early primordia of the organs that will form the excretoryand reproductive systems. In particular we havefound that Emx2 is expressed in the epithelial componentsof pronephros and mesonephros, in Wolffian andMüllerian ducts, in the ureteric buds with their branchesand in the early epithelial structures derived from metanephrogenic mesenchyme. Emx2 is also intensely expressedin the “bipotential” or “indifferent” gonads andovaries. These data and the recent finding that Emx2 homozygousmutant mice die soon after birth because ofthe absence of kidneys indicate an essential role of Emx2in the morphogenesis of the urogenital system
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
La composizione corporea: dal laboratorio alla clinica
No full textI nutrienti influenzano lo stato di nutrizione di un soggetto attraverso diverse variabili quali l’introduzione, l’assorbimento e l’utilizzazione degli stessi. Indagare queste variabili, tuttavia, risulta essere poco funzionale mentre possiamo efficacemente concentrarci soltanto su una di queste tre, l’utilizzazione, che risulta direttamente influenzata dalle due precedenti. Illustrando il concetto di utilizzazione possiamo vedere, secondo un modello operativo dinamico, come lo stato di salute sia legato in modo biunivoco allo stato nutrizionale (OMS/WHO, 1998) attraverso due grandi variabili: quella psico-sociale e quella biologica. Di queste due macrocomponenti la variabile biologica risulta costituita da composizione corporea, bilancio energetico e funzioni corporee che sono valutabili dal nutrizionista attraverso metodiche invasive e metodiche non-invasive. Lo studio della composizione corporea è il miglior indicatore a lungo termine dello stato nutrizionale della persona poiché riflette la disponibilità pregressa di nutrienti. Queste caratteristiche risultano particolarmente evidenti in una popolazione altamente specifica e ben caratterizzata
Nutritional Status Evaluation: Body Composition and Energy Balance
No full textNutritional status is the result of our lifestyle over the long term and a major determinant of our health. The balance between energy we ingest as food and energy we expend in the course of physiological processes during our daily activities defines our body composition, a key component of nutritional status. A positive energy balance is at the base of overweight and obesity, where a generalized or a central increase in fat mass is associated with a higher cardio-metabolic risk.
In order to plan an effective dietary intervention, we need to know the current body composition in terms of fat mass and fat-free mass and the basal metabolic rate, that is, the energy expenditure at rest in the postabsorptive state. Basal metabolic rate can be assessed by estimate equations or measured by calorimetry. Body composition can be measured or estimated in the field, at the bedside or clinic, or in the laboratory. Anthropometry, body impedance assessment, dual X-ray absorptiometry, and imaging techniques like computed tomography and magnetic resonance imaging are more commonly used in the clinical settings, while densitometry and dilution methods are typical laboratory methods.
Information on body composition and energy expenditure represent a powerful tool available to the health-care worker who deals with nutrition for the prevention or treatment of obesity-associated cardio-metabolic diseases
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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