1,720,963 research outputs found
EPSP-spike potentiation during primed burst-induced long-term potentiation in the CA1 region of rat hippocampal slices.
No full textLong-term potentiation induced by high-frequency stimulation in the CA1 region of the hippocampus exhibits EPSP-spike potentiation. This consists of an increase in population spike amplitude exceeding that predicted by EPSP potentiation alone. This phenomenon is apparently due to an increase in pyramidal cell excitability. Patterns of afferent stimuli which activate pyramidal cells to reproduce the theta rhythm observed in the hippocampus under physiological conditions, have been shown to induce LTP-like enhancement of synaptic responses in vitro. The aim of this study was to investigate the presence of EPSP-spike potentiation and/or changes in pyramidal cell excitability during the long-term potentiation induced in the CA1 region of rat hippocampal slices by theta-like patterns of stimuli: the primed burst and the patterned stimulation. Using extracellular recording, a significant leftward shift in the EPSP-spike relationship was found 30 min after primed burst or patterned stimulation. The magnitude of EPSP-spike potentiation induced by patterned stimulation was similar to that produced by high-frequency stimulation. Both were significantly greater than that induced by a primed burst, indicating that only a subset of pyramidal cells were potentiated by this kind of afferent activation. Modifications in synaptic efficacy and cell excitability brought about by a primed burst were investigated in 25 intracellularly recorded pyramidal cells. Consistent with extracellular results, it was found that only 11 out of 25 neurons receiving a primed burst were potentiated. In these cells the increase in probability of firing action potentials elicited by synaptic activation with test shocks was accompanied by enhanced cell excitability, but not by an increase in EPSP slope. High-frequency stimulation delivered 40 min after a primed burst invariably increased the EPSP slope, the probability of firing upon synaptic stimulation, and the excitability of cells. The presence of EPSP-spike potentiation and of increased excitability of potentiated cells during the primed burst-induced long-term potentiation strengthen the suggestion that theta pattern-induced synaptic potentiation can be considered similar to high-frequency stimulation and long-term potentiation and supports the notion that the EPSP-spike potentiation is a constitutive characteristic of long-term potentiation
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Histamine mediates behavioral and metabolic effects of 3-iodothyroacetic acid (TA1), an endogenous end product of thyroid hormone metabolism
No full textBackground and purpose
3-iodothyroacetic acid (TA1) is among the end products of thyroid hormone metabolism. To now, it is unknown if TA1 is present in the brain of rodents and if it has any pharmacological effects.
Exeprimental approach
We measured TA1 levels in the brain of mice by HPLC coupled to mass spectrometry and then we investigated whether pharmacological administration of TA1 modified memory, pain and plasma glycemia. 15 min after intracerebroventricular (i.c.v.) injection of TA1 (0.4, 1.32 and 4 μgkg-1) mice memory acquisition-retention, pain threshold to hot stimulus (51.5°C) and plasma glycemia were evaluated on the light-dark box, on the hot plate and by a glucorefractometer respectively. Parallel experiments were performed in mice pre-treated with subcutaneous injections of pyrilamine (10 mgkg-1) or zolantidine (5 mgkg-1), antagonists of histamine H1 and H2 receptors respectively. Furthermore, TA1 (1.32 and 4 μgkg-1) was i.c.v. injected in histidine decarboxylase null (HDC-/-) and their HDC+/+ littermate mice.
Results
TA1 was present in the brain of CD1 but not of HDC mice. Pharmacological activity of TA1 included amnesia (at the dose of 0.4 μgkg-1), stimulation of learning (at 1.32 and 4 μgkg-1), hyperalgesia (at 0.4, 1.32 and 4 μgkg-1 ) and hyperglycemia (at 1.32 and 4 μgkg-1). All these effects were modulated by pyrilamine and zolantidine. In HDC-/- mice, TA1 (1.32 and 4 μgkg-1, i.c.v. injected ) failed to increase plasma glycemia and to reduce pain threshold.
Conclusions and implications
TA1 behavioral and metabolic effects reveal an interplay between the thyroid and the histaminergic syste
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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