111,870 research outputs found
Arthritis as a rare side effect of phenytoin therapy.
No full textArthritis as a rare side effect of phenytoin therapy”.
P. Carfagna, E. Pistella, V. Paravati, P. Serra.
European Journal of Internal Medicine 12: 448-450, 2001
Auditory cue based on the golden ratio can improve gait patterns in people with parkinson’s disease
No full textThe harmonic structure of walking relies on an irrational number called the golden ratio (φ): in healthy subjects, it coincides with the stride-to-stance ratio, and it is associated with a smooth gait modality. This smoothness is lost in people with Parkinson’s disease (PD), due to deficiencies in the execution of movements. However, external auditory cues seem to facilitate movement, by enabling the timing of muscle activation, and helping in initiating and modulating motor output. Based on a harmonic fractal structure of gait, can the administration of an auditory cue based on individual’s φ-rhythm improve, in acute, gait patterns in people with PD? A total of 20 participants (16 males, age 70.9 ± 8.4 years, Hoehn and Yahr stage-II) were assessed through stereophotogrammetry: gait spatio-temporal parameters, and stride-to-stance ratio were computed before, during, and after the φ-rhythm administration. Results show improvements in terms of stride length (p = 0.018), walking speed (p = 0.014), and toe clearance (p = 0.013) when comparing gait patterns before and after the stimulus. Furthermore, the stride-to-stance ratio seems to correlate with almost all spatio-temporal parameters, but it shows the main changes in the before–during rhythm comparison. In conclusion, φ-rhythm seems an effective cue able to compensate for defective internal rhythm of the basal ganglia in PD
author-bios-SRD-19-0063.R1 – Supplemental material for The Network Structure of Police Misconduct
No full textSupplemental material, author-bios-SRD-19-0063.R1 for The Network Structure of Police Misconduct by George Wood, Daria Roithmayr and Andrew V. Papachristos in Socius</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Effect of reduced body weight on muscle aerobic capacity in patients with COPD
No full textBackground: Reduced muscle aerobic capacity in COPD patients has been demonstrated in several laboratories by phosphorus magnetic resonance spectroscopy and by analysis of oxygen uptake ((V) over dot o(2)) kinetics, COPD patients are usually elderly, hypoxemic, poorly active with muscle atrophy, and often malnourished Under these conditions there is usually reduction of O-2 deliver to the tissues (bulk O-2 flow), redistribution of fiber type within the muscle, capillary rarefaction, and decreased mitochondrial function, alterations all capable of reducing muscle aerobic capacity, In COPD, the effect of reduced body mass on muscle aerobic capacity has not been investigated (to our knowledge), Methods: We studied 24 patients with stable COPD with moderate-to-severe airway obstruction (68+/-5 [SD] years; FEV1, 39+/-12% predicted; PaO2, 66+/-8 mm Hg; PaCO2, 41+/-3 mm Hg) with poor to normal nutritional status, as indicated by a low-normal percent of ideal body weight (IBW). Each subject first underwent 1-min maximal incremental cycle ergometer exercise for determination of (V) over dot o(2) peak and lactate threshold (LT), Subsequently, they performed a 10-min moderate (80% of LT-(V) over dot o(2)) constant load exercise for determination of oxy-gen deficit (O2DEF) and mean response time (V) over dot o(2) (MRT). (V) over dot o(2), CO2 output ((V) over dot co(2)), and minute ventilation were measured breath by breath, Results: Patients displayed low (V) over dot o(2) peak (1,094+/-47 [SE] mL/min), LT-(V) over dot o(2) (35+/-3% predicted (V) over dot o(2) max), and higher MRT-(V) over dot o(2) (67+/-4 s), Univariate regression analysis showed that percent of IBW correlated with indexes of maximal and submaximal aerobic capacity: vs (V) over dot o(2) peak, R=0.53 (p<0.01); vs MRT R=-0.77 (p<0.001). Using stepwise I egression analysis, MRT correlated (R-2=-0.70) with percent of IBW (p<0.01) and with PaO2 (p<0.05). Conclusions: Reduced body mass has an independent negative effect on muscle aerobic capacity in COPD patients: this effect may explain the variability in exercise tolerance among patients with comparable ventilatory limitation
Cloud-Native Software Development Life Cycle: A Case Study with Italian Ministry of Justice
No full textIn recent years, the Cloud Computing paradigm has witnessed rapid and extensive adoption across diverse industries and sectors. This transition to Cloud-based solutions has fundamentally transformed the landscape of software development and deployment. Consequently, prioritizing Cloud compatibility in the software development lifecycle has become imperative for developers and organizations. This paper aims to offer a comprehensive and detailed overview of the software development lifecycle tailored for Cloud-based software. We will delve into the entire process, spanning from conception to deployment, elucidating key stages, methodologies, and best practices. Throughout the manuscript, we will underscore the significance of employing the most effective tools and techniques available to streamline development processes and maximize the benefits of Cloud Computing. Through the utilization of Cloud-native technologies, such as containerization and orchestration frameworks, developers can augment scalability, reliability, and performance in their Cloud-based applications. Additionally, we will present a case study exemplifying a software development lifecycle for Cloud-based software. This case study is based on the logical infrastructure devised by the Italian Ministry of Justice to manage the introduction of new functionalities in their services, following a DevOps cycle
Clinical and haemodynamic effects of Ivabradine in patients with acute ischemic heart failure
No full textOur data suggest that, in patients with acute ischemie heart fail
ure, /vabradine is effective for c.ontrolling the heart rate as well as for clinica! and l1aemodynamic recovery. The FC control, without any influence on BP values, im proves the outcorne of these patients. preventing the further deterioration of leh ventricular funclionAn elevateci heart rate (HR) is an independent risk factor lor mor tality and morbidity in patients with acute heart failure. Pharmacologic inhibition of the l(f) current provides the opportunity of pure HR reduction, wh1ch has been associateci with anti-ischemic efficacy w1thout any effect on haemodynamic or rny ocardial contractility. SHIFT trial has evaluated /vabradine benefits in heart failure patients showing a significant decrease in the composite rate of card,ovascular death or heart-failure hosp1talization
Antiplatelet therapy in elderly patients with acute coronary syndrome. between scientific evidence and future perspectives
No full textDual antiplatelet therapy (DAPT) is an important strategy for reducing cardiovascular events (CV) after an acute coronary syndrome (ACS). Elderly patients undergoing DAPT have a higher risk of bleeding than younger patients for a variety of reasons. Stratification of thrombotic/hemorrhagic risk is mandatory in order to decide on the type and duration of DAPT. The percentage of patients ≥ 75 years represented in clinical trials is not large, so very often elderly people are prescribed treatment protocols only experimented on younger patients with a lower hemorrhagic risk. However, even in patients aged ≥ 75 treated with invasive or conservative therapy, after an ACS, a DAPT with aspirin 80-100 mg/day plus a P2Y12 receptor inhibitor for 12 months is recommended. In elderly patients, DAPT should be considered a dynamic process that can be modified over time based on the patient's clinical conditions, or any other necessities (non-procrastinating surgical interventions, comorbid-like effects that can increase hemorrhagic risk). In patients with moderate-high or very high hemorrhagic risk, DAPT treatment should last less than 12 months. A prolongation of DAPT beyond 12 months in this setting is limited to a very low percentage of patients, after careful assessment of ischemic/hemorrhagic profile
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