1,721,178 research outputs found
Real-Time Analysis of the Log Files of the HeartWare Continuous-Flow Left Ventricular Assist Device for the Early Diagnosis of Pump Thrombosis: a Step Forward Toward Clinical Translation
No full textWe evaluated the real-time diagnostic capability of a new tool enhancing early diagnosis of pump thrombosis (PT) of the HeartWare left ventricular assist device via time-frequency analysis (TFA) of the log files. We analyzed 173 log files, including 24 (14%) associated with a clinical diagnosis of PT and 149 (86%) controls. The 30-day log file records were discretized into consecutive windows of a 24-h duration, which were iteratively acquired and processed via TFA. This way, we simulated longitudinal acquisition of pump parameters and provided real-time analysis of consecutive data, thus resembling the clinical scenario. Sensitivity and specificity of the tool were 79% and 84%, respectively. Sensitivity against PT events with progressive “build-up” thrombus increased up to 95%, and early signs of a forthcoming PT were identified 10±8 days prior to its clinical manifestation. This study demonstrates high reliability and the potential for effective clinical translation of this prognostic tool
The MWM Method for Kinetic Equations Systems
No full textAbstractMany physical or biological phenomena deal with the dynamics of interacting entities. These class of phenomena are well described in physics, using a kinetic approach based on Boltzmann equation. A Generalized Kinetic theory has been proposed to extend this approach to biological scenarios. An analytical solution of Boltzmann equation can be found only in very simple cases, so numerical methods become extremely relevant. The particle method is a class of numerical methods used to find a numerical solution of Boltzmann equations. The MWF-method for kinetic equations was firstly proposed by S. Motta and J. Wick in 1992. Here, we show that the MWF-method can be extended to system of Boltzamm equations
Primary mechanical unloading in high-risk myocardial infarction: Perspectives in view of a paradigm shift
No full textThe improvement achieved in recent years in early myocardial infarction (MI) mortality poses several new clinical challenges, owing to late consequences of myocardial loss and the significant incidence of heart failure (HF) observed thereafter. A still unaddressed residual reperfusion injury (RI) contributes to final infarct size, acute MI mortality and longer-term HF development. Despite many cardioprotective lines of research in the setting of MI, no treatment has significantly altered clinical practice or convincingly improved outcomes either. Left ventricular mechanical unloading before culprit vessel reopening may reduce RI and prime (biologically and mechanically) the myocardium for reperfusion, thus limiting infarct size and preventing subsequent adverse remodeling. Aim of this review is to summarize key pre-clinical and clinical experiences furnishing a rationale to the approach of mechanical unloading before myocardial reperfusion with a translational outlook on its implications for the management of MI patients
La legislazione regionale e la legge 285/97. Note in tema di protezione e di partecipazione
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