10 research outputs found
Dr. Leandros A. Maglaras
No full textDr. Leandros A. Maglaras is Associate Professor in the School of Computer Science and Informatics of De Montfort University, conducting research in the Cyber Security Centre. He obtained the B.Sc. (M.Sc. equivalent) in Electrical and Computer Engineering from the Aristotle University of Thessaloniki, Greece in 1998, M.Sc. in Industrial Production and Management from the University of Thessaly in 2004, and M.Sc. and Ph.D. degrees in Electrical & Computer Engineering from University of Thessaly, in 2008 and 2014 respectively. In 2018 he was awarded a second Ph.D. in Intrusion Detection in SCADA systems from the University of Huddersfield. He serves on the Editorial Board of several international peer-reviewed journals such as IEEE Access, Elsevier Array, Elsevier ICT Express and Emerald Continuity & Resilience Review. He is the author of more than 140 papers in scientific magazines and conferences and is a senior member of the IEEE.https://www.interscience.in/mentors/1066/thumbnail.jp
Ο Λέανδρος του Παναγιώτη Σούτσου (1834): Πρωτοποριακό ρομαντικο‐ελληνικό μυθιστόρημα
No full textIt seems that Λέανδρος (Leandros), written in 1834 by Panaghiotis Sutsos (1806-1868) and commonly regarded as the first modern Greek novel, is indeed the best expression, among contemporary novels, of the profound dilemma of Greek society after independence, namely the desire to display a classical profile and, at the same time, to adapt to the demands of modernity. In the novel, the author, a man of letters and an official of the new state administration, reflects at the same time the situation in contemporary Greece
Birkhoff's Decomposition Revisited: Sparse Scheduling for High-Speed Circuit Switches
No full textData centers are increasingly using high-speed circuit switches to cope with the growing demand and reduce operational costs. One of the fundamental tasks of circuit switches is to compute a sparse collection of switching configurations to support a traffic demand matrix. Such a problem has been addressed in the literature with variations of the approach proposed by Birkhoff in 1946 to decompose a doubly stochastic matrix exactly. However, the existing methods are heuristic and do not have theoretical guarantees on how well a collection of switching configurations (i.e., permutations) can approximate a traffic matrix (i.e., a scaled doubly stochastic matrix). In this paper, we revisit Birkhoff's approach and make three contributions. First, we establish the first theoretical bound on the sparsity of Birkhoff's algorithm (i.e., the number of switching configurations necessary to approximate a traffic matrix). In particular, we show that by using a subset of the admissible permutation matrices, Birkhoff's algorithm obtains an ε-approximate decomposition with at most O( log(1 / ε)) permutations. Second, we propose a new algorithm, Birkhoff+, which combines the wealth of Frank-Wolfe with Birkhoff's approach to obtain sparse decompositions in a fast manner. And third, we evaluate the performance of the proposed algorithm numerically and study how this affects the performance of a circuit switch. Our results show that Birkhoff+ is superior to previous algorithms in terms of throughput, running time, and number of switching configurations.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Embedded System
Δύναμη στην άρση μπάρας στους μηρούς και επίδοση στο επολέ της άρσης βαρών
No full textΣκοπός της παρούσας εργασίας είναι η πειραματική διερεύνηση της συσχέτισης μεταξύ της μέγιστης δύναμης στην άρση της μπάρας στους μηρούς (deadlift) και της επίδοσης στη κίνηση επολέ (clean) της Άρσης Βαρών. Δεκαέξι προπτυχιακοί φοιτητές φυσικής αγωγής ειδικευόμενοι στο άθλημα της Ολυμπιακής Άρσης Βαρών συμμετείχαν σε αυτή τη μελέτη (n=16, ηλικία: 25 ± 7 χρόνια, σωματικό βάρος: 73 ± 12 κιλά, ύψος: 174 ± 9 εκατοστά). Τα ανθρωπομετρικά χαρακτηριστικά μετρήθηκαν μέσω μηχανήματος DEXA scan στο εργαστήριο Μυϊκής Ενδυνάμωσης του Τμήματος Επιστήμης Φυσικής Αγωγής και Αθλητισμού (ΤΕΦΑΑ) ενώ οι μετρήσεις της επίδοσης μίας μέγιστης επανάληψης (1 ΜΕ) στην άρση μπάρας στους μηρούς και στην κίνηση επολέ της Άρσης Βαρών πραγματοποιήθηκαν στις προπονητικές εγκαταστάσεις του Σταδίου Ειρήνης και Φιλίας (ΣΕΦ), όπου και πραγματοποιούν την προπόνηση τους οι φοιτητές. Τα αποτελέσματα της στατιστικής ανάλυσης έδειξαν σχεδόν τέλεια γραμμική συσχέτιση (r=0,94, p=0,05) ανάμεσα στη μέγιστη δύναμη στην άρση μπάρας στους μηρούς (deadlift) και στην επίδοση στο επολέ (clean). Τα αποτελέσματα αυτά υποδεικνύουν ότι η άσκηση της άρσης μπάρας στους μηρούς μπορεί να αποτελέσει προγνωστικό παράγοντα της επίδοσης στο επολέ σε τεχνικά καταρτισμένους αθλητές/αθλούμενους στην Άρση Βαρών. Επιπρόσθετα, η άρση μπάρας στους μηρούς μπορεί να αποτελέσει ένα ισχυρό προπονητικό εργαλείο.ΟΧ
Teilhard de Chardin and the new geological paradigms in the xxth Century. In the centennial of Eduard Suess
No full textThe centenary of Eduard Suess’s geologist death, on the 26th of April, 1914, is the occasion to inquire into the knowledge Teilhard had of the innovative ideas in the Earth Sciences and the acceptance on his part of those paradigms that contributed to his work as geologist in China during twenty years. In the year 1921, Pierre Teilhard de Chardin publishes in Études, the review of the French Jesuits, an article which he titles as «The face of the Earth». The author is seeking to inform the readers of the most outstanding ideas of one of the great geologists of the late Nineteen Century and the beginning of the Twentieth: Eduard Suess. This research offers the possibility of philosophically reflecting on the epistemology hidden in Teilhard de Chardin and which contributes, in a decisive way, to the construction of his great synthesis. A century ago, between 1912 and 1914, a young Pierre Teilhard de Chardin devoted his time to study of the prehistory in Paris directed by Marcellin Boule in the Human Palaeontological Institute, attached to Natural History Museum. Teilhard discovered that the humanity rooths knowledge can be posible by means the prehistory, a new emergent discipline. Excited by that discovery, he publishsed a paper in 1913 in Études, a review edited by the french jesuits, where he justified the prehistory scientific character and their potentiallity for reached the human origins knowledge
Sustainable experimental cultivation of the Greek endemic Helichrysum amorginum Boiss. and Orph.: Assessment of the total phenolic content at different flower harvest stages
No full textHelichrysum amorginum Boiss. and Orph. constitutes a range-restricted, endemic species of Greece with known pharmaceutical potency. The current work presents the results of a targeted evaluation of the total phenolic content (TPC) of methanolic extracts of H. amorginum flower heads under cultivation conditions at three consecutive harvest stages in two separate cultivation locations across a period of two years (2018 and 2019). The harvested inflorescence tissue was assessed for TPC via the Folin–Ciocalteu method in three and four-year old H. amorginum individuals. Older plants, during the second evaluation year, generally showed higher flower TPC content throughout. The pooled analysis of the results indicated significant differences in TPC among samples of extracts prepared with plant material from different harvest stages with the early flowering stage (A) presenting higher TPC in both experimental cultivation locations (142.6–156 mg GAE g-1 extract on average among the two cultivation locations) followed by the full bloom stage (B) (139–145.7 mg GAE g-1 extract on average) and the late bloom or early post-anthesis stage (C) which showed the lowest TPC in all cases (130.3–131 mg GAE g-1 extract on average). The current results provide for the first-time basic information on the optimum inflorescence harvest stage during the prolonged flowering period of cultivated H. amorginum in terms of TPC. The proposed work can be incorporated into the establishment of a sustainable cultivation protocol for achieving polyphenol-rich extracts and ultimately contributes to the utilization of H. amorginum in the pharmaceutical/cosmetic sectors. The journal offers free, immediate, and unrestricted access to peer-reviewed research and scholarly work. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. License - Articles published in Notulae Botanicae Horti Agrobotanici Cluj-Napoca are Open-Access, distributed under the terms and conditions of the Creative Commons Attribution (CC BY 4.0) License. © Articles by the authors; Licensee UASVM and SHST, Cluj-Napoca, Romania. The journal allows the author(s) to hold the copyright/to retain publishing rights without restriction
Author Correction: Deficiency of TET3 leads to a genome-wide DNA hypermethylation episignature in human whole blood (npj Genomic Medicine, (2021), 6, 1, (92), 10.1038/s41525-021-00256-y):Deficiency of TET3 leads to a genome-wide DNA hypermethylation episignature in human whole blood (npj Genomic Medicine, (2021), 6, 1, (92), 10.1038/s41525-021-00256-y)
No full textIn this article the author name Siddharth Banka was incorrectly written as Sidharth Banka. The original article has been corrected.</p
Milesiaka, I. Meandrio
No full textThe name of Meandrius varies in the sources between Maiandrios, Leandrios and Leandros: the present edition attributes the whole corpus of fragments transmitted under the three mentioned names to Meandrius of Miletus, according to the tradition opened by C. Keil and authoritatively supported, among the others, by A. Meineke, J. Mikolajczak and F. Jacoby. Nothing certain can be said about his life and chronology: the concise indication «Before Callimachus» given by Jacoby introducing the fragments is the only certain information; but indications of different type and different reliability converge in seeing him as a local historian of the Hellenistic age, a little bit older than Callimachus or almost contemporary to him.
Such chronological dating, though approximate, is enough to state that Meandrius has not been the first author of Milesiaka: certainly before him has to be placed at least Clytus’s work, whom Athenaeus defines as pupil of Aristotle. But a large number of Meandrius’s fragments reached us, much higher than those of all other milesian local historians: hence the decision not to follow a chronological sequence and to devote instead to Meandrius’s fragments the first of the volumes that the Series «I Frammenti degli Storici greci» reserves to the Milesiaka, also because for the Meandrius’s fragments it is possible, although with many doubts and difficulties, to catch a comprehensive view. Fragments – numerically exiguous – by other authors, preceding and subsequent, for whom it is in doubt even their existence, will be gathered in the second volume, presently in preparation.
In the light of the recent debate about the editing of fragmentary texts, which led to define new criteria that put in the foreground the study of the context, of the transmission events and of the transmitting sources, the present volume collects and numbers the fragments of Meandrius on the basis of the source that preserves each, in a sequence reflecting source chronology (it would be anyhow impossible for Meandrius to rearrange the fragments in a sequence reflecting their original place in the structure of the work). Wherever possible, all fragments handed down by the same source have been put together in a single section: thus, as a result, there are sections devoted to fragments handed down by Callimachus, by Strabo, by Diogenes Laertius, by Clemens Alexandrinus; out of these sections are placed a number of fragments that constitute a unique quotation by an author.
The work of Meandrius was structured at least in two books; we do not known the title – as frequently happens with ancient quotations – in a unique form but it varied between the general Historiai and the more technical Milesiaka. From the fragments surviving today we can infer isolated «contents», but we are not able to understand their importance and their place inside the work: no supposition is possible about the starting point of the work and how far it went, nor can we determine whether it dealt with the polis of Miletus only, or it ranged up to cover also their colonies. What we can say with certainty is that in Meandrius’s work a number of versions and trends of local elaboration come together, mainly on topics regarding Miletus and their interests, which systematically give prominence or clarify the position of Miletus versus other poleis; it can be perceived in the work the need of defining and protecting whichever made up the town patrimony at all levels, from the origins of the polis up to the chora, to the myths, to the political relationship
Bromo-substituted indirubins for inhibition of protein kinase-mediated signalling involved in inflammatory mediator release in human monocytes
No full textTargeting protein kinases that regulate signalling pathways in inflammation is an effective pharmacological approach to alleviate uncontrolled inflammatory diseases. In this context, the natural product indirubin and its 6-bromo-substituted analogue 6-bromoindirubin-3 -glycerol-oxime ether (6BIGOE; 1) were identified as potent inhibitors of glycogen synthase kinase-3β (GSK-3β). These inhibitors suppress the release of pro-inflammatory cytokines and prostaglandins (PG) from human monocytes. However, indirubin derivatives target several protein kinases such as cyclin-dependent kinases (CDKs) which has been a major concern for their application in inflammation therapy. Here, we report on a library of 13 5-bromo-substituted indirubin derivatives that have been designed to improve potency and target selectivity. Side-by-side comparison of reference compound 1 (6BIGOE) with 5-bromo derivatives revealed its isomer 2 (5BIGOE), as the most potent derivative able to supress pro-inflammatory cytokine and PG release in lipopolysaccharide-stimulated human monocytes. Analysis of protein kinase inhibition in intact monocytes, supported by our in silico findings, proposed higher selectivity of 1 for GSK-3β inhibition with lesser potency against CDKs 8 and 9. In contrast, 2 supressed the activity of these CDKs with higher effectiveness than GSK-3β, representing additional targets of indirubins within the inflammatory response. Encapsulation of 1 and 2 into polymer-based nanoparticles (NP) improved their pharmacological potential. In conclusion, the 5- and 6-brominated indirubins 1 and 2 as dual GSK-3β and CDK8/9 inhibitors represent a novel concept for intervention with inflammatory disorders. © 2024 The Author(s
Strain relaxation and multidentate anchoring in n-type perovskite transistors and logic circuits
No full textThe engineering of tin halide perovskites has led to the development of p-type transistors with field-effect mobilities of over 70 cm2 V−1 s−1. However, due to their background hole doping, these perovskites are not suitable for n-type transistors. Ambipolar lead halide perovskites are potential candidates, but their defective nature limits electron mobilities to around 3–4 cm2 V−1 s−1, which makes the development of all-perovskite logic circuits challenging. Here we report formamidinium lead iodide perovskite n-type transistors with field-effect mobilities of up to 33 cm2 V−1 s−1 measured in continuous bias mode. This is achieved through strain relaxation of the perovskite lattice using a methylammonium chloride additive, followed by suppression of undercoordinated lead through tetramethylammonium fluoride multidentate anchoring. Our approach stabilizes the alpha phase, balances strain and improves surface morphology, crystallinity and orientation. It also enables low-defect perovskite–dielectric interfaces. We use the transistors to fabricate unipolar inverters and eleven-stage ring oscillators. © The Author(s), under exclusive licence to Springer Nature Limited 2024
