26 research outputs found
Identificación del factor inhibidor de la activación de macrófagos presente en el líquido de ascitis del tumor L5178Y por Rebeca Palacios Corona
No full textIdentificación del factor inhibidor de la activación de macrófagos presente en el líquido de ascitis del tumor L5178Y
Get PDFSe ha informado que existe un estado de inmunodepresíón tanto en
pacientes como en animales portadores de tumores malignos. Estudios in vitro
con células malignas han demostrado la existencia de factores inhibidores de la
activación de los macrófagos en el sobrenadante de los cultivos. Estudios
similares con el homogenado celular de algunos tumores de tipo mastocítoma,
también han demostrado un efecto inhibidor sobre los macrófagos
Efecto del factor inhibidor de la activación de los macrófagos producido por el linfoma murino L5178Y sobre el desarrollo de abscesos hepáticos inducidos por Listeria monocytogenes Y Entamoeba histolytica en ratones inmunocompetentes
Get PDFDeficiencia de la B-galactosidasa en poblaciones con retardo mental en el area metropolitana de Monterrey, N.L. Mexico
No full textThe Macrophage-Activation Inhibitory Factor (MAIF) from L5178Y Murine Lymphoma Favors Experimental Amebic Hepatic Abscess Development in Balb/c Mice
No full textIntegration and comparison of different genomic data for outcome prediction in cancer
No full textIn cancer, large-scale technologies such as next-generation sequencing and microarrays have produced a wide number of genomic features such as DNA copy number alterations (CNA), mRNA expression (EXPR), microRNA expression (MIRNA), and DNA somatic mutations (MUT), among others. Several analyses of a specific type of these genomic data have generated many prognostic biomarkers in cancer. However, it is uncertain which of these data is more powerful and whether the best data-type is cancer-type dependent. Therefore, our purpose is to characterize the prognostic power of models obtained from different genomic data types, cancer types, and algorithms. For this, we compared the prognostic power using the concordance and prognostic index of models obtained from EXPR, MIRNA, CNA, MUT data and their integration for ovarian serous cystadenocarcinoma (OV), multiform glioblastoma (GBM), lung adenocarcinoma (LUAD), and breast cancer (BRCA) datasets from The Cancer Genome Atlas repository. We used three different algorithms for prognostic model selection based on constrained particle swarm optimization (CPSO), network feature selection (NFS), and least absolute shrinkage and selection operator (LASSO)
Integration and comparison of different genomic data for outcome prediction in cancer
No full textClinical data per cancer type. (XLSX 9 kb
Los esquemas espaciales de la morfología verbal aplicados a la referencia de partes del cuerpo en wixárika o huichol. Dimensión Antropológica Vol. 69 Año 24 (2017) enero-abril
No full textCampbell, Lyle, Terrence Kaufman y Thomas C. Smith-Stark, “Meso-America as a Linguistic Area”, Language, vol. 62, núm. 3, 1986, pp. 530-570.Castillo Hernández, Mario Alberto, “El léxico de las partes del cuerpo en el mexicano de la sierra noreste de Puebla”, Dimensión Antropológica, año 18, vol. 51, enero-abril, 2011, pp. 33-48.Cuevas Suárez, Susana, “Las partes del cuerpo humano en amuzgo y su proyección semántica”, Dimensión Antropológica, año 18, vol. 51, enero-abril, 2011, pp. 79-102.De León, Lourdes, “Body Parts and Location in Tozotzil: Ongoing Grammaticalization”, Zeitschrift für Phonetik, Sprachwissenschaft und Kommunikationsforschung (ZPSK), vol. 45, núm. 6, 1992, pp. 570-589.Friedrich, Paul, “Metaphor-Like Relations between Referential Subsets”, Lingua, vol. 24, 1969, pp. 1-10.____________, “Shape in Grammar”, Language, vol. 46, núm. 2, 1970, pp. 379-407.Gómez López, Paula, “Apuntes para un estudio de la posesión en huichol”, Lingüística Mexicana, vol. 1, núm. 1, 2000, pp. 13-25.____________, “La adquisición de la expresión espacial en wixárika o huichol”, Función, núm. 31-32, Universidad de Guadalajara, 2008.____________, “La expresión lingüística del espacio en wixárika o huichol: una caracterización tipológica”, en Rebeca Barriga Villanueva y Esther Herrera Zendejas (eds.), Lenguas, estructuras y hablantes. Estudios en Homenaje a Thomas Smith-Stark, vol. 2. México, El Colegio de México, 2014, pp. 871-888.Iturrioz Leza, José Luis, “Inkorporation”, en Martin Haspelmath et al. (eds.), Language Typology and Language Universals, vol. I, Berlín, Walter de Gruyter, 2001, pp. 714-725.____________, Paula Gómez López y Julio Ramírez de la Cruz, “Localización en huichol: jerarquías de paradigmas y series funcionales”, Función, vol. 8, Universidad de Guadalajara, 1988, pp. 111-166.____________, y Paula Gómez López, Gramática wixárika I, Múnich, Lincom Europa, 2006.López Corona, Georgete Aimme, “Verbos con partes del cuerpo humano en el zapoteco de San Pablo Güilá”, Dimensión Antropológica, año 18, vol. 51, enero-abril, 2011, pp. 131-152.MacLaury, Robert, “Zapotec Body-Part Locatives: Prototypes and Metaphoric Extensions”, IJAL, vol. 55, núm. 2, 1989, pp. 119-154.Monzón, Cristina, Los morfemas espaciales del p’urhépecha, México, El Colegio de Michoacán, 2004.Levinson, Stephen C., “Vision, Shape, and Linguistic Description: Tzeltal Body-Part Terminology and Object Description”, Linguistics, vol. 32, 1994, pp. 791-855.____________, y John B. Haviland. “Introduction: Spatial Conceptualization in Mayan languages”, Linguistics, vol. 32, 1994, pp. 613-622.Levy, Paulette, “Body Part Prefixes in Papantla Totonac”, Zeitschrift für Phonetik, Sprachwissenschaft und Kommunikationsforschung (ZPSK), vol. 45, núm. 6, 1992, pp. 530-542.Peral Rabasa, Francisco, “Léxico de las partes del cuerpo humano y algunas de sus extensiones semánticas en el hñähñu de Xochimilco y San Pablito Pahuatlán, Puebla”, Dimensión Antropológica, año 18, vol. 51, enero-abril, 2011, pp. 49-78.Rengifo Mattos, Karina y Paula Gómez López, “La adquisición temprana de nombres y verbos: contraste entre español y huichol”, ponencia presentada en el XI Encuentro de Adquisición del Lenguaje, en la Universidad Autónoma de Querétaro, 24 de septiembre de 2009.Smith-Stark, Thomas. C., “Mesoamerican Calques”, en Carolyn J. MacKay y Verónica Vázquez (eds.), Investigaciones lingüísticas en Mesoamérica, México, UNAM, 1994, pp. 15-52.Stolz, Christel, y Thomas Stolz, “Mesoamerica as a Linguistic Area”, en Martin Haspelmath, Ekkehard König, Wulf Oesterreicher y Wolfgang Raible (eds.), Language Typology and Language Universals 2. (HSK 20.2), Berlín / Nueva York, Walter de Gruyter, 2001, pp. 1539-1553.Suárez, Jorge, The Mesoamerican Indian Languages, Cambridge, Cambridge University Press, 1983.Svorou, Soteria, The Grammar of Space, Ámsterdam / Filadelfia, John Benjamins, 1994.El wixárika comparte con las lenguas mesoamericanas la importancia de la expresión espacial, pero es atípico como lengua del área en algunos aspectos: 1) Los términos de partes del cuerpo funcionan, pero de manera limitada como fuente para la formación de expresiones de lugar. 2) Algunos prefijos verbales forman esquemas espaciales generales que se utilizan para hacer referencia a las partes del cuerpo, a objetos materiales y al entorno geográfico. Las cuestiones planteadas por MacLaury y Levinson acerca de la manera en que los términos de partes del cuerpo se extienden a los objetos y a la expresión de relaciones espaciales en estas lenguas no es la más importante en wixárika. La cuestión más interesante, en esta lengua, es de qué manera se aplican los esquemas espaciales generales del verbo al hacer referencia a las partes del cuerpo.As with many Mesoamerican languages, spatial expression is important in Wixárika; nonetheless, it is an atypical Mesoamerican language in certain aspects: 1) Body parts serve in only a limited way as a source for the formation of expressions of place. 2) Verb prefixes of space form general spatial schemes that are used to reference body parts, material objects, and geographical surroundings. The issues discussed by MacLaury (1989) and Levinson (1994) about the way in which terms for body parts extend to objects and to the expression of spatial relations in these languages are not of central importance in the case of Wixárika. The most interesting question in this language is how the general spatial schemes of verbs are applied when referencing body parts
Disease surveillance during the reintroduction of the Iberian Lynx (Lynx pardinus) in southwestern Spain
Get PDFThis article belongs to the Section Wildlife.The restoration of Iberian lynx (Lynx pardinus) populations in Extremadura (Southwestern Spain) have been carried out since 2014. One of the measures to ensure the success of this program is to examine the effects that diseases may have on reintroduction. Since diseases may be greatly located at certain sites because of the specific ecological requirements of the pathogens and/or vectors, reintroduced individuals may present a risk of infection once released. To determine which pathogens the reintroduced individuals may encounter, we performed a molecular and sero-epidemiological survey in reintroduced and wild-born lynxes. From 2015 to 2019, 69 Iberian lynxes (40 reintroduced and 29 wild-born) were sampled and screened against 10 viral, bacterial and piroplasmid agents. In parallel, 195 sympatric carnivores from the families Canidae, Felidae, Viverridae, Herpestidae and Mustelidae were tested against current or past infections to six common canine/feline viruses. In the Iberian lynx, low contact rates of active infection were obtained for the feline leukemia provirus (FeLV: 1.5%; 1/67), feline parvovirus (FPV: 1.5%; 1/67) and Cytauxzoon sp. (6.7%; 1/15). We also confirmed the emergence of Aujeszky’s disease (suid herpesvirus-1) in this population (SuHV-1: 11.8%; 2/17). Evidence of previous exposure was detected for canine distemper virus (CDV: 5.8%; 3/52), feline coronavirus (1.9%; 1/52), FPV (7.7%; 1/13) and feline calicivirus (FCV: 5.3%; 1/19). From 25 recovered lynx carcasses, we could confirm infectious etiology involvement in the death of four individuals (SuHV-1 in two individuals, coinfection of Cytauxzoon spp. and Aeromonas veronii in one lynx and a Streptococcus canis myositis in another lynx). We confirmed the circulation of CDV, FPV, FeLV, FCV and the feline immunodeficiency virus within the sympatric carnivore community. Due to the low contact rate of infectious agents in such a small, endangered population, we recommend continuing a disease surveillance program to determine the prognostic factors of survival, understand the role that disease may play during the reintroduction and anticipate disease outbreaks that may pose a risk for the entire reintroduced population.[Simple Summary]: The restoration of Iberian lynx (Lynx pardinus) populations in Extremadura (Southwestern Spain) have been carried out since 2014. To evaluate the effect that infectious diseases may have on their reintroduction, we performed a molecular and sero-epidemiological survey in reintroduced and wild-born lynxes and sympatric carnivores. From 2015 to 2019, 69 Iberian lynxes were screened against 10 viral, bacterial and piroplasmid agents. In parallel, 195 sympatric carnivores were tested against current or past infections to six common canine/feline viruses. In the Iberian lynx, low contact rates of active infection were obtained for feline leukemia provirus (FeLV: 1.5%; 1/67), feline parvovirus (FPV: 1.5%; 1/67) and Cytauxzoon sp. (6.7%; 1/15). We confirmed the emergence of Aujeszky’s disease (suid herpesvirus-1) in this population (SuHV-1: 11.8%; 2/17). We detected the circulation of FeLV, parvovirus, canine distemper virus (CDV), feline calicivirus (FCV) and feline immunodeficiency virus within the sympatric carnivore community and FCV, FPV, CDV and feline coronavirus in lynxes. Due to the low contact rate of infectious agents in such a small, endangered population, we recommend continuing a disease surveillance program to determine the prognostic factors of survival, understand the role that disease may play during the reintroduction and anticipate disease outbreaks that may pose a risk for the entire reintroduced population.This research was funded by the European Union through its LIFE project Life+IBERLINCE (LIFE+10NAT/ES/570) “Recuperación de la distribución histórica del lince ibérico (Lynx pardinus) en España y Portugal”.Peer reviewe
Radiogenomics analysis identifies correlations of digital mammography with clinical molecular signatures in breast cancer
No full textIn breast cancer, well-known gene expression subtypes have been related to a specific clinical outcome. However, their impact on the breast tissue phenotype has been poorly studied. Here, we investigate the association of imaging data of tumors to gene expression signatures from 71 patients with breast cancer that underwent pre-treatment digital mammograms and tumor biopsies. From digital mammograms, a semi-automated radiogenomics analysis generated 1,078 features describing the shape, signal distribution, and texture of tumors along their contralateral image used as control. From tumor biopsy, we estimated the OncotypeDX and PAM50 recurrence scores using gene expression microarrays. Then, we used multivariate analysis under stringent cross-validation to train models predicting recurrence scores. Few univariate features reached Spearman correlation coefficients above 0.4. Nevertheless, multivariate analysis yielded significantly correlated models for both signatures (correlation of OncotypeDX = 0.49 ± 0.07 and PAM50 = 0.32 ± 0.10 in stringent cross-validation and OncotypeDX = 0.83 and PAM50 = 0.78 for a unique model). Equivalent models trained from the unaffected contralateral breast were not correlated suggesting that the image signatures were tumor-specific and that overfitting was not a considerable issue. We also noted that models were improved by combining clinical information (triple negative status and progesterone receptor). The models used mostly wavelets and fractal features suggesting their importance to capture tumor information. Our results suggest that molecular-based recurrence risk and breast cancer subtypes have observable radiographic phenotypes. To our knowledge, this is the first study associating mammographic information to gene expression recurrence signatures.</div
