284 research outputs found
Neuroanatomical scaling, neurotopography of gene expression, and sex chromosome aneuploidy
No full textThe publication of topographically-defined, whole-transcriptome quantifications in the human brain has created the opportunity to mine the association of imaging findings with genetic data. An increasingly popular analysis is to connect groupwise anatomical differences in imaging space with differential expression of genes as defined by their topographical expression across the cortical mantle.
This thesis uses this approach to address two problems in neuroimaging: 1) total brain size normalization and 2) association of anatomical changes with gene expression in health.
The thesis begins by examining surface area scaling in the cortex and subcortex. It describes the regions of non-linear surface area scaling in both compartments --- and claims those foci of non-linear scaling may pose challenges for the analysis of disease.
Next, the thesis considers the biological meaning of surface area scaling in the cortex by comparing regions of non-linear scaling to known maps of developmental and evolutionary expansion --- among others. A spatially sensitive bootstrapping procedure is introduced to quantify similarity or disimilarity amongst cortical maps.
Lastly, this thesis applies a scaling-sensitive normalization framework for total brain size differences in the analysis of a neurogenetic disease cohort. In particular, scaling-sensitive analysis of the striatum, thalamus, and globus pallidus in Sex Chromosome Aneuploidy results in increased specificity for disease specific anatomical changes in both nucleus volume and shape.</p
The case of Mobility as a Service: A critical reflection on challenges for urban transport and mobility governance
No full textThis chapter provides a reflective critique of Mobility as a Service (MaaS), an emerging development seeking a role within the Smart Mobility paradigm. We assess a range of its future implications for urban policymakers in terms of governance and sustainability (i.e., social and environmental impacts). We begin by describing the origins of the MaaS concept, along with the features of precursor technologies and current early examples. We then reflect on the marketing of MaaS and use it to consider how we might anticipate some potentially less desirable aspects of the promoted business models. Finally, we discuss the implications for governance.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Spatial Planning and StrategyTransport and Plannin
A year into the pandemic:shifts, improvisations and impacts for people, place, and policy
No full textThis chapter provides an overarching framework for exploring the relationships between people, place and policy and living with the COVID-19 pandemic. It recognises that these three Ps are interdependent; people are embedded in places and local and national policy is developed and applied to places. The chapter starts by exploring the debate on risk societies, non-calculable uncertainty, and the emergence of Jenga capitalism as a precursor for exploring the impacts of Covid-19. It then explores the relationship between globalisation and disease, before outlining national responses to COVID-19, including the emergence of socially distanced economies. The chapter also considers some dimensions of life after the pandemic, including a discussion of the impacts on policy and taxation. In so doing, the Chapter highlights Covid-19 as a cultural inflection point. The Chapter concludes by providing an outline of the contributions to the edited collection of the same name, to which this chapter forms the introduction
Supermarkets, New-Generation Wholesalers, Tomato Farmers, and NGOs in Nicaragua
No full textBased on a survey of 145 tomato farmers and interviews with supermarket chains, NGOs, wholesalers, and farmer organizations in 2004, this paper examines the determinants and effects of farmers' participation in supermarket channels, with and without assistance from NGOs in "business linkage" programs. It finds that absent that assistance, the farmers that work with supermarket chains tend to be the "upper tier" of small farmers, better capitalized with various assets. The smaller and less-capitalized farmers that work with supermarkets tend to do so in association with NGO assistance. Despite higher input expenditures and entry requirements, farmers in the supermarket chain earn more. The paper discusses the issue of whether this development program approach is sustainable and can be upscaled, and wrestles with the tradeoff of helping poor farmers gain access to dynamic markets, of making it affordable at a larger scale by national governments with tight budgets, and at the same time field programs that are market-sustainable and market-responsive.Marketing,
Letter from M. J. Riordan to Carl Hayden
No full textLetter from Michael J. Reardon to Carl T. Hayden, in agreement with Ralph Cameron, asserting that Bright Angel Trail should not be sold from Coconino County to the United States
Women in environmental disasters: the 1991 cyclone in Bangladesh
No full textThe author is a female relief worker who has seen first-hand how women are more vulnerable than men to natural disasters, and in their aftermath. She explores why women are more likely to die in environmental disasters, and why emergency relief aid often fails to benefit women. Begum makes recommendations for ensuring that women's needs are taken into account when planning and delivering relief work.
This article is hosted by our co-publisher Taylor & Francis. For the full table of contents for this and previous issues of this journal, please visit the Gender and Development website
The News and the Accused
No full textThe author believes that the Reardon Standards, if implemented, would provide an effective solution to the problem of prejudicial information, and that this potential can be best realized through adoption and enforcement of the Standards by the courts. This conclusion is based upon analysis of the following issues: (1) The nature of the problem, including an examination of (a) the nature of prejudicial information, (b) those who create the problem either by initially releasing or subsequently disseminating such information, and (c) the related effect of courtroom procedure upon the impact of such information. An analysis of these issues suggests that a procedure must be developed which can control those persons who either leak or disseminate prejudicial information and which will diminish the deleterious impact of such information. (2) The effectiveness of present regulations. The author concludes that existing safeguards do not, in fact, protect the accused\u27s right to an impartial jury trial. (3) The effectiveness of press media codes. The author concludes that while these codes offer a new approach, they are inherently incapable of providing a feasible solution to the problem. (4) The effectiveness of the Reardon Standards. In examining this issue, the collateral issues of the interpretation of the Standards and their relation to freedom of the press will be analyzed. The author concludes that the Standards, if diligently enforced, offer a solution to the problem that will be both effective and will not violate the constitutional guarantee of freedom of the press. (5) The agency which could best adopt and enforce the Reardon Standards. It is the author\u27s conclusion that the courts, rather than police departments, bar associations or legislatures would be best suited to implement these Standards. The author suggests that the Standards be adopted through rule of court by the appellate courts in the various jurisdictions
Location, location, location: A comparative analysis of UK, Malaysian and Singaporean consumer views of palm oil
No full textWith the ever-increasing population, global demand for palm oil has increased exponentially due its use in food, cosmetics, detergents and biofuel. In the UK, palm oil has been represented negatively in the media and online campaigns, predominately due to known environmental concerns. Yet with consumers exposed to such a perspective, how much do they really know about palm oil? Contrastingly, it appears that consumers from Southeast Asian palm oil-producing countries view this commodity in a more positive light, focusing more on its economic and social benefits. With much existing literature focusing on the environmental and health concerns of palm oil, consumer views have been neglected. Accordingly, this study aims to fill a gap in literature by investigating to what extent and in which ways such consumer awareness, knowledge and perceptions on palm oil differ between UK and Malaysian consumers. Essentially, consumers are the key to change; understanding what they know allows institutions to act accordingly to facilitate such change. Central to this is the values beliefs norms theory that explores how values affect beliefs, which in turn affect norms and subsequently action. Using a mixed methods triangulation approach of semi-structured interviews, an online survey and focus groups, data collection reveals that Malaysian consumers are generally significantly more aware as to what palm oil is and its uses, as well as having a more positive view of palm oil than UK consumers. This wider knowledge can be accredited to the types of media and ways in which the media portrays palm oil
Multinationals or cooperatives: does it matter to farmers? A case study of the Indian dairy sector.
No full textBreaking the Stigma: Faculty and Student Perceptions and Experiences with OER
No full textOver the last few years, Affordable Learning Georgia, an initiative of the University System of Georgia, has been releasing Textbook Transformation Grants to promote creation and adoption of open educational resources across USG institutions. Many of the faculty at Kennesaw State University, located just outside Atlanta, Georgia, have taken advantage of these grants to create, revise, remix, and reuse OER in their online, hybrid, and face-to-face courses in place of expensive textbooks. As of March 2018, 26 teams at KSU had been awarded Textbook Transformation Grants, and those projects have a combined estimated annual impact of $3.5 million saved among an estimated 13,467 students each year, and counting. This presentation and paper will outline the various open textbooks created, resources gathered, and classes transformed by ALG grants at KSU. It will also explore the student perceptions of these projects based on survey data; grade and withdrawal statistics in comparison to the same classes with expensive textbooks; and faculty perceptions and experiences with their created, reused, and remixed OER within their classes
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