315,104 research outputs found
Dr. Lin Sun, CAU, March 2013
No full textThis video is a conversation with Dr. Lin Sun. Dr. Sun talks about an exhibit at the Woodruff Library titled "At The Boundary." Jordan Moore, AUC Woodruff Library, is the interviewer
The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing
No full textLin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA (miRNA) let-7. Lin-41 was recently reported to mediate ubiquitylation and degradation of the miRNA pathway protein Ago2. We demonstrate that Lin-41 is over-expressed in hepatocellular carcinoma (HCC). Lin-41 over-expression correlates with high a-fetoprotein level, high tumour grade and high tumour stage and predicts early tumour recurrence. Lin-41 is a strong predictor of poor long-term survival for patients with HCC. Lin-41 knock-down by RNA interference in HCC cell lines Huh7 and Hep3B suppressed proliferation in vitro and reduced in vivo tumour growth in NOD/SCID mice. On the other hand, over-expression of Lin-41 in the HCC cell line SK-Hep1 enhanced tumourigenicity. Over-expression and knock-down of Lin-41 led to inverse changes in the levels of Ago1 and Ago2 proteins. Over-expression of Ago1 and Ago2 reduced in vivo tumour growth. Lin-41 over-expression suppressed let-7 activity in HCC cell lines and expression of Lin-41 enhanced the expression of let-7-regulated oncogenes c-Myc, Lin-28B, HMGA2 and type 1 insulin-like growth factor receptor (IGF1R). Expression of Lin-28B and c-Myc enhanced the expression of Lin-41. Chromatin immunoprecipitation and reporter assays revealed direct association of c-Myc with the Lin-41 promoter, resulting in transcriptional transactivation. Our results indicate that Lin-41 plays an important role in the growth of HCC by regulating RISC complex proteins Ago1 and Ago2 to inhibit miRNA-mediated gene silencing and promote the expression of oncogenic proteins. Lin-41 is also a strong prognostic factor for patients with HCC. Copyright (C) 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd
An Analysis of <i>Judge Lin</i>
No full textBiography of Lin Wen Zhong Gong has another way to call, that is Judge Lin. The leading character is Lin Ze-Xu. This book is based on functionary experience of Lin Ze-Xu, with the captivating plots of court case, helping by highly skilled military attach\uc3\ua9s and chivalrous knights, and the history facts of Opium War. It makes Lin Ze-Xu\ue2s Confucian temperament and tragic mood more, also contrasts with author\ue2s sorrow and furiousness for the politics at the time. History, court case, martial arts\ue2\ua6\ue2\ua6etc. are essence of this book and it broadens the way of this writing style.
The topic of the thesis is \ue2An Analysis of Judge Lin\ue2. The following thesis will be divided into six different chapters. The introduction is Chapter one of the thesis, which is including researching motive and purpose, literature review of predecessors, researching version by existing information, raising questions, choosing research methods and arranging chapters. In chapter Two, I discuss the study of characters of Lin Ze-Xu, also makes a deep analysis of author\u27s purpose of writing him. In chapter Three, I analyze supporting actors and actress. Meanwhile, I illustrate author\u27s purpose of writing supporting actress because the author had different manner to describe supporting actress. Moving to the Chapter Four, I mainly focus on the plots of Judge Lin, and organize cases of Lin Ze-Xu and his subordinates to understand features of cases. In Chapter Five, I represent the causes of Opium War. China and England had difference of opinions of opium. Therefore, it is easier to comprehend what the author\u27s purpose is. In the last chapter I summarize the main points of the preceding chapters and confirm particularity of Judge Lin
Lasioseius fujianensis Ma & Lin 2013
No full textLasioseius fujianensis Ma & Lin , 2013 Lasioseius fujianensis Ma & Lin, 2013: 34. TYPE DEPOSITORY: Institute of Plant Protection, Fujian Academy of Agricultural Science, Fuzhou, China. TYPE LOCALITY AND HABITAT: Zhangping, 25 ° 18 'N, 117 ° 24 'E, Fujian, China, on mandarin orange [Plantae: Rutaceae].Published as part of De Moraes, Gilberto J., Britto, Erika P. J., Mineiro, Jefferson L. De C. & Halliday, Bruce, 2016, Catalogue of the mite families Ascidae Voigts & Oudemans, Blattisociidae Garman and Melicharidae Hirschmann (Acari: Mesostigmata), pp. 1-299 in Zootaxa 4112 (1) on page 169, DOI: 10.11646/zootaxa.4112.1.1, http://zenodo.org/record/39947
Lasioseius wuyishanensis Ma & Lin 2013
No full textLasioseius wuyishanensis (Ma & Lin , 2013) Neolaspina wuyishanensis Ma & Lin, 2013: 35 TYPE DEPOSITORY: Institute of Plant Protection, Fujian Academy of Agricultural Science, Fuzhou, China. TYPE LOCALITY AND HABITAT: Guangze (27 ° 33 ' N, 117 ° 20 ' E), Wuyishan Mountain, Fujian, China, in moss.Published as part of De Moraes, Gilberto J., Britto, Erika P. J., Mineiro, Jefferson L. De C. & Halliday, Bruce, 2016, Catalogue of the mite families Ascidae Voigts & Oudemans, Blattisociidae Garman and Melicharidae Hirschmann (Acari: Mesostigmata), pp. 1-299 in Zootaxa 4112 (1) on page 191, DOI: 10.11646/zootaxa.4112.1.1, http://zenodo.org/record/39947
Asca hainanensis Ma & Lin 2008
No full text<p> <b> <i>Asca hainanensis</i> Ma & Lin</b> , <b>2008</b></p> <p> <i>Asca hainanensis</i> Ma & Lin, in Ma <i>et al</i>., 2008: 582. <i>Asca hainanensis</i>.— Ma & Lin, 2014: 21.</p> <p>TYPE DEPOSITORY: Entomology Gallery, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China.</p> <p>TYPE LOCALITY AND HABITAT: Dongshanling, Wanning, Hainan, China, in leaf litter.</p>Published as part of <i>De Moraes, Gilberto J., Britto, Erika P. J., Mineiro, Jefferson L. De C. & Halliday, Bruce, 2016, Catalogue of the mite families Ascidae Voigts & Oudemans, Blattisociidae Garman and Melicharidae Hirschmann (Acari: Mesostigmata), pp. 1-299 in Zootaxa 4112 (1)</i> on page 95, DOI: 10.11646/zootaxa.4112.1.1, <a href="http://zenodo.org/record/399477">http://zenodo.org/record/399477</a>
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