166 research outputs found
(2-AMINOETHYL)IMIDAZOLES.SYNTHESIS OF 1,4-DIMETHYL-5-PHENYL-2-[2-(4-PHENYLPIPERAZINYL)ETHYL]IMIDAZOLE
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Delineation of Subsurface Structures in TOJA Field in the Niger Delta Using Well-Logs and Seismic Data
No full textThe subsurface structures delineation of TOJA Field southwest Niger Delta using well-log and seismic data is here presented. The reflectivity seismic amplitude and acoustic impedance, spectra decomposition volume derivatives were used for reservoir delineation. Seismic data and well logs have been integrated through seismic inversion as part of the techniques deployed in the delineation of subsurface structures in the Niger Delta basin. Well logs were tied to seismic data using four wells from four fields in the Niger Delta. Reflectivity seismic data was inverted to generate a 3D distribution of P-impedance in the fields of interest. Fluid and lithology sensitivity analysis including cross-plotting, forward seismic modelling and Gassmann fluid substitution was performed to delineate various subsurface structures. The TOJA prospect is a footwall-closure located behind the main bounding fault, north of the TOJA Field. The Field’s structure is a fault-dependent footwall closure with a dip component in the shallow levels. The structure is bounded by three faults; a large east-west fault forms the boundary between the TOJA Field to the South and the TOJA North Field. This fault is relayed by a minor fault that delimits the south-western end of the accumulation. A northeast-southwest bounding fault separates the TOJA structure from the SATRA accumulations to the east and has a throw of between 200 and 400 ft. The results of this study can lead to a more cost-effective method for defining the Field Development Plan (FDP), through the use of seismically constrained reservoir information that would provide better well placement to achieve improved production
Midnight salivary cortisol versus urinary free and midnight serum cortisol as screening tests for Cushing's syndrome
No full textThe diagnosis of Cushing's syndrome (CS) is often a challenge. Recently, the determination of late night salivary cortisol levels has been reported to be a sensitive and convenient screening test for CS. However, no studies have included a comparison with other screening tests in a setting more closely resembling clinical practice, i.e. few patients with CS to be distinguished from patients with pseudo-Cushing states (PC), including the large population of obese patients. The aim of this study was to compare the diagnostic performance of midnight salivary cortisol (MSC) measurement with that of midnight serum cortisol (MNC) and urinary free cortisol (UFC) in differentiating 41 patients with CS from 33 with PC, 199 with simple obesity, and 27 healthy normal weight volunteers. Three patients with CS had MSC levels lower than the cut-off point derived from receiver operator characteristic analysis (9.7 nmol/liter), yielding a sensitivity for this parameter of 92.7%. In the whole study population, no statistically significant differences in terms of sensitivity, specificity, diagnostic accuracy, and predictive values were observed among tests. In particular, the overall diagnostic accuracy for MSC (93%; 95% confidence interval, 90.1-95.9%) was similar to those of UFC (95.3%; 94.1-96.5%) and MNC (95.7%; 93.4-98%; both P = NS). The diagnostic performance of MSC was superimposable to that of MNC also within the area of overlap in UFC values (< or =569 nmol/24 h) between CS and PC. In conclusion, MSC measurement can be recommended as a first-line test for CS in both low risk (simple obesity) and high-risk (i.e. PC) patients. Given its convenience, this procedure can be added to tests traditionally used for this purpose, such as UFC and MNC
Electrocardiographic QT interval in patients with Cushing's syndrome treated by ketoconazole
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Degradation of nitrocellulose-based paint by Desulfovibrio desulfuricans ATCC 13541
No full textNitrocellulose is one of the most commonly used compounds in ammunition and paint industries and its recalcitrance to degradation has a negative impact on human health and the environment. In this study the capability of Desulfovibrio desulfuricans ATCC 13541 to degrade nitrocellulose as binder in paint was assayed for the first time. Nitrocellulose-based paint degradation was followed by monitoring the variation in nitrate, nitrite and ammonium content in the culture medium using Ultraviolet-Visible spectroscopy. At the same time cell counts and ATP assay were performed to estimate bacterial density and activity in all samples. Infrared spectroscopy and colorimetric measurements of paint samples were performed to assess chemical and colour changes due to the microbial action. Microscope observations of nitrocellulose-based paint samples demonstrated the capability of the bacterium to adhere to the paint surface and change the paint adhesive characteristics. Finally, preliminary studies of nitrocellulose degradation pathway were conducted by assaying nitrate- and nitrite reductases activity in D. desulfuricans grown in presence or in absence of paint. We found that D. desulfuricans ATCC 13541 is able to transform nitrocellulose as paint binder and we hypothesised ammonification as degradation pathway. The results suggest that D. desulfuricans ATCC 13541 is a good candidate as a nitrocellulose-degrading bacterium
The relationship between knowledge, attitude, and readiness of academic community in Covid-19 spread prevention: Batari Toja Nursing Academy, Watampone
No full textThis study aims to determine the relationship between knowledge, attitude, and the readiness of the academic community in the prevention of COVID-19 spread in Batari Toja Nursing Academy, Watampone. The type of study was an analytical survey using a cross-sectional study design. The number of samples in this study was 30 respondents selected using a purposive sampling technique. Furthermore, data were collected using a questionnaire. Data were then processed by utilizing SPSS v.22 with univariate and bivariate analyses and the Chi-square statistical test, then, presented in the form of frequency distribution tables. This study showed that, from the result of the Chi-square test, the relationship between knowledge and readiness was indicated with a p-value of 0.003 < (? = 0.05) while the relationship between attitude and readiness was indicated with a p-value of 0.019 < (? = 0.05) meaning that there is a relationship between knowledge along with attitude and the readiness of the academic community related to prevention of COVID-19 spread in Batari Toja Nursing Academy, Watampone. 
No Untoward Effect of Long-Term Ketoconazole Administration on Electrocardiographic QT Interval in Patients with Cushing's Disease
No full textKetoconazole is listed among drugs that prolong QT interval and may increase the risk of torsade de pointes, a severe ventricular arrhythmia. This compound has recently been approved for treatment of Cushing's syndrome, a severe endocrine disorder. These patients harbour several risk factors for prolonged QT interval, for example hypokalaemia and left ventricular hypertrophy, but no study has evaluated whether administration of ketoconazole affects their QT interval. The aim of this study was to assess the QT interval in patients with Cushing's disease during long-term administration of ketoconazole. Electrocardiograms from 15 patients with Cushing's disease (12 women, 3 men, age: 37.8 ± 2.66 years) on ketoconazole treatment (100 mg-800 mg qd) for 1 month to 12 years were reviewed retrospectively. QT interval was measured and corrected for heart rate (QTc). Measurements before and during ketoconazole treatment were compared and any abnormal QTc value recorded. Concurrent medical therapies were also documented. On average, QTc was superimposable before and during ketoconazole treatment (393.2 ± 7.17 versus 403.3 ± 6.05 msec. in women; 424.3 ± 23.54 versus 398.0 ± 14.93 msec. in men, N.S.). QTc normalized on ketoconazole in one man with prolonged QTc prior to treatment; no abnormal QTc was observed in any other patient during the entire observation period, even during concurrent treatment with other QT-prolonging drugs. In conclusion, long-term ketoconazole administration does not appear to be associated with significant prolongation of QT interval in patients with Cushing's disease. ECG monitoring can follow recommendations drawn for other low-risk QT-prolonging drugs with attention to specific risk factors, for example hypokalaemia and drug interactions
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