5,900 research outputs found

    Indological studies essays in memory of Shri S. P. Singhal

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    Festschrift honoring S.P. (Swadesh Prasad) Singhal, 1946-1986, Indian publisher

    D. P. Singhal : India and World Civilization

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    Filliozat Jean. D. P. Singhal : India and World Civilization. In: Bulletin de l'Ecole française d'Extrême-Orient. Tome 58, 1971. pp. 312-313

    Damodar P. Singhal : Nationalism in India and other historical essays

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    Filliozat Jean. Damodar P. Singhal : Nationalism in India and other historical essays. In: Bulletin de l'Ecole française d'Extrême-Orient. Tome 58, 1971. pp. 316-317

    V. Singhal, Handbook of Indian Agriculture

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    Étienne Gilbert. V. Singhal, Handbook of Indian Agriculture. In: Tiers-Monde, tome 38, n°152, 1997. p. 951

    V. Singhal, Handbook of Indian Agriculture

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    Étienne Gilbert. V. Singhal, Handbook of Indian Agriculture. In: Tiers-Monde, tome 38, n°152, 1997. p. 951

    Effect of repaglinide and gliclazide on postprandial control of endogenous glucose production

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    The effect of repaglinide and gliclazide on postmeal suppression of endogenous glucose production (EGP) has been studied using a variable-rate tracer methodology. Groups of age-, sex-, and weight-matched type 2 diabetic subjects randomized to gliclazide or repaglinide were studied after ingesting a standard mixed meal (550 kcal; 67% carbohydrate, 19% fat, 14% protein). Plasma glucose profiles were similar in each group and markedly different from that of a nondiabetic control group. Endogenous glucose production was similar basally (3.01 +/- 0.30 vs 3.06 +/- 0.19 mg/kg per minute, gliclazide and repaglinide, respectively). After glucose ingestion, EGP declined rapidly in both the groups until 30 minutes and the greatest suppression was reached earlier in the repaglinide group [0.88 mg/kg per minute at 120 minutes vs 0.77 mg/kg per minute at 210 minutes in gliclazide group (P .02) but not significantly different in the repaglinide group (153 +/- 25 mg/kg per min 2 ; P = .17). Repaglinide has minimal physiological advantage over gliclazide, but both therapies for type 2 diabetes fall far short of correcting the endocrine and metabolic abnormalities

    Regulation of endogenous glucose production after a mixed meal in type 2 diabetes

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    The extent and time course of suppression of endogenous glucose production (EGP) in type 2 diabetes after a mixed meal have been determined using a new tracer methodology. Groups of age-, sex-, and weight-matched normal controls (n = 8) and diet-controlled type 2 diabetic subjects (n = 8) were studied after ingesting a standard mixed meal (550 kcal; 67% carbohydrate, 19% fat, 14% protein). There was an early insulin increment in both groups such that, by 20 min, plasma insulin levels were 266 +/- 54 and 190 +/- 53 pmol/l, respectively. EGP was similar basally [2.55 +/- 0.12 mg x kg(-1) x min(-1) in control subjects vs. 2.92 +/- 0.16 mg x kg(-1) x min(-1) in the patients (P = 0.09)]. After glucose ingestion, EGP declined rapidly in both groups to approximately 50% of basal within 30 min of the meal. Despite the initial rapid decrease, the EGP was significantly greater in the diabetic group at 60 min (1.75 +/- 0.12 vs. 1.05 +/- 0.14 mg x kg(-1) x min(-1); P < 0.01) and did not reach nadir until 210 min (0.96 +/- 0.17 mg x kg(-1) x min(-1)). Between 60 and 240 min, EGP was 47% higher in the diabetic group (0.89 +/- 0.09 vs. 1.31 +/- 0.13 mg x kg(-1) x min(-1), P < 0.02). These data quantitate the initial rapid suppression of EGP after a mixed meal in type 2 diabetes and the contribution of continuing excess glucose production to subsequent hyperglycemia

    A Second-Order Observation of Organizational Deviance

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    In this chapter, Andrea Fried and Arvind Singhal highlight which novel research questions break ground when taking a second-order perspective on organizational deviance. The concept of the ‘second-order observer’ for researchers leaves the assessment of organizational deviance explicitly to the empirical field, and brings organizations and their members as describers, as assessors, and as sanctioners of organizational deviance into the discussion. The chapter strengthens social agency in deviations from standards to counteract the view that deviants are a ‘passive non-entity’. Fried and Singhal describe how organizational deviance has three dimensions and can analytically be distinguished as a descriptive, a normative, and a sanctioning aspect. The chapter concludes with six assignments for developing a concept of organizational deviance.</p
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