1,075 research outputs found
The overview of online courses of russian as a foreign language
No full textIn this article the author describes in detail the online courses of Russian as a foreign language offered by leading Russian universities. The structure of the courses and the use of the English language as an interlanguage are analysed too. Referring to the researchers, the author draws conclusions about the effectiveness, importance and feasibility of using Internet technologies in teaching foreign languages
ENGLISH AND ITS ROLE BY ONLINE TEACHING OF RUSSIAN AS A FOREIGN LANGUAGE
No full textВ данной статье рассматривается вопрос о понятии языка-посредника, роли английского языка в процессе онлайн-обучения иностранных студентов русскому языку разных этапах обучения. Автор описывает онлайн-курсы русского языка как иностранного, анализирует функции английского языка как посредника. Ссылаясь на мнение исследователей, автор делает выводы об эффективности, важности и целесообразности его использования.=The article considers the essence of the concept of interlingua, the role of English by online teaching of Russian as a foreign language at different levels. The author describes online courses of Russian as a foreign language, analyses functions of English as interlingua. Referring to the opinion of researchers, conclusions about the effectiveness, importance and appropriateness of its use are made
THE EFFECTS OF VARIOUS SALINITY AND TEMPERATURE CONDITIONS ON THE GROWTH RATE OF LEPRALIA PALLASIANA MOLL. COLONIES (Vliyanie Uslovii Razlichnoi Solenosti i Temperatury na Temp Rosta Kolonii Korkovoi Mshanki Lepralia Pallasiana Moll.),
No full textTHE REACTION OF THE BLACK SEA B. IMPROVISUS DARWIN TO REDUCED SALINITIES (Otnoshenie Chernomorskogo Usonogogo Rachka Balanus Improvisus Darwin K Usloviyam Ponizhennoi Solonesti)
No full textAuthor Correction: A portrait of the Higgs boson by the CMS experiment ten years after the discovery
No full textIn the version of this article initially published, CMS Collaboration author names, affiliations and acknowledgements were omitted and have now been included in the HTML and PDF versions of the articl
If you can't be with the one you love, love the one you're with: How individual habituation of agent interactions improves global utility
No full textSimple distributed strategies that modify the behaviour of selfish individuals in a manner that enhances cooperation or global efficiency have proved difficult to identify. We consider a network of selfish agents who each optimise their individual utilities by coordinating (or anti-coordinating) with their neighbours, to maximise the pay-offs from randomly weighted pair-wise games. In general, agents will opt for the behaviour that is the best compromise (for them) of the many conflicting constraints created by their neighbours, but the attractors of the system as a whole will not maximise total utility. We then consider agents that act as 'creatures of habit' by increasing their preference to coordinate (anti-coordinate) with whichever neighbours they are coordinated (anti-coordinated) with at the present moment. These preferences change slowly while the system is repeatedly perturbed such that it settles to many different local attractors. We find that under these conditions, with each perturbation there is a progressively higher chance of the system settling to a configuration with high total utility. Eventually, only one attractor remains, and that attractor is very likely to maximise (or almost maximise) global utility. This counterintutitve result can be understood using theory from computational neuroscience; we show that this simple form of habituation is equivalent to Hebbian learning, and the improved optimisation of global utility that is observed results from wellknown generalisation capabilities of associative memory acting at the network scale. This causes the system of selfish agents, each acting individually but habitually, to collectively identify configurations that maximise total utility
Observation of Λ Hyperon Local Polarization in p-Pb Collisions at √sNN=8.16 TeV
No full textThe polarization of the Λ and ̄Λ hyperons along the beam direction has been measured in proton-lead (p-Pb) collisions at a center-of-mass energy per nucleon pair of 8.16 TeV. The data were obtained with the CMS detector at the LHC and correspond to an integrated luminosity of 186.0±6.5 nb−1
. A significant azimuthal dependence of the hyperon polarization, characterized by the second-order Fourier sine coefficient Pz,s2, is observed. The Pz,s2 values decrease as a function of charged particle multiplicity, but increase with transverse momentum. A hydrodynamic model that describes the observed Pz,s2 values in nucleus-nucleus collisions by introducing vorticity effects does not reproduce either the sign or the magnitude of the p-Pb results. These observations pose a challenge to the current theoretical implementation of spin polarization in heavy ion collisions and offer new insights into the origin of spin polarization in hadronic collisions at LHC energies
Plasma p-tau₁₈₁ shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau
No full textIntroduction:
We examined the ability of plasma hyperphosphorylated tau (p-tau)181 to detect cognitive impairment due to Alzheimer's disease (AD) independently and in combination with plasma total tau (t-tau) and neurofilament light (NfL). /
Methods:
Plasma samples were analyzed using the Simoa platform for 235 participants with normal cognition (NC), 181 with mild cognitive impairment due to AD (MCI), and 153 with AD dementia. Statistical approaches included multinomial regression and Gaussian graphical models (GGMs) to assess a network of plasma biomarkers, neuropsychological tests, and demographic variables. /
Results:
Plasma p-tau181 discriminated AD dementia from NC, but not MCI, and correlated with dementia severity and worse neuropsychological test performance. Plasma NfL similarly discriminated diagnostic groups. Unlike plasma NfL or t-tau, p-tau181 had a direct association with cognitive diagnosis in a bootstrapped GGM. /
Discussion:
These results support plasma p-tau181 for the detection of AD dementia and the use of blood-based biomarkers for optimal disease detection
Observation of Λ Hyperon Local Polarization in p-Pb Collisions at =8.16 TeV
No full textThe polarization of the Λ and hyperons along the beam direction has been measured in proton-lead (p-Pb) collisions at a center-of-mass energy per nucleon pair of 8.16 TeV. The data were obtained with the CMS detector at the LHC and correspond to an integrated luminosity of 186.0 6.5 nb. A significant azimuthal dependence of the hyperon polarization, characterized by the second-order Fourier sine coefficient P, is observed. The P values decrease as a function of charged particle multiplicity, but increase with transverse momentum. A hydrodynamic model that describes the observed P values in nucleus-nucleus collisions by introducing vorticity effects does not reproduce either the sign or the magnitude of the p-Pb results. These observations pose a challenge to the current theoretical implementation of spin polarization in heavy ion collisions and offer new insights into the origin of spin polarization in hadronic collisions at LHC energies
Table_1_Targeted Sequencing of Alzheimer Disease Genes in African Americans Implicates Novel Risk Variants.XLSX
No full textThe genetic architecture of late-onset Alzheimer disease (AD) in African Americans (AAs) differs from that in persons of European ancestry. In addition to APOE, genome-wide association studies (GWASs) of AD in AA samples have implicated ABCA7, COBL, and SLC10A2 as AA-AD risk genes. Previously, we identified by whole exome sequencing a small number of AA AD cases and subsequent genotyping in a large AA sample of AD cases and controls association of AD risk with a pair of rare missense variants in AKAP9. In this study, we performed targeted deep sequencing (including both introns and exons) of approximately 100 genes previously linked to AD or AD-related traits in an AA cohort of 489 AD cases and 472 controls to find novel AD risk variants. We observed association with an 11 base-pair frame-shift loss-of-function (LOF) variant in ABCA7 (rs567222111) for which the evidence was bolstered when combined with data from a replication AA cohort of 484 cases and 484 controls (OR = 2.42, p = 0.022). We also found association of AD with a rare 9 bp deletion (rs371245265) located very close to the AKAP9 transcription start site (rs371245265, OR = 10.75, p = 0.0053). The most significant findings were obtained with a rare protective variant in F5 (OR = 0.053, p = 6.40 × 10-5), a gene that was previously associated with a brain MRI measure of hippocampal atrophy, and two common variants in KIAA0196 (OR = 1.51, p-5). Gene-based tests of aggregated rare variants yielded several nominally significant associations with KANSL1, CNN2, and TRIM35. Although no associations passed multiple test correction, our study adds to a body of literature demonstrating the utility of examining sequence data from multiple ethnic populations for discovery of new and impactful risk variants. Larger sample sizes will be needed to generate well-powered epidemiological investigations of rare variation, and functional studies are essential for establishing the pathogenicity of variants identified by sequencing.</p
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