213 research outputs found
Gaze-evoked amaurosis - post reconstruction of orbital floor fracture with a bone graft: Case report
No full textRicky Kumar, Simon N. Madge, Dinesh Selva, Phil Pirgousis and Alastair N. Gos
sj-pdf-1-pie-10.1177_09544089221077661 - Supplemental material for Influence of rotation speeds on microstructure and mechanical properties of welded joints of friction stir welded AA2014-T6/AA6061-T6 alloys
No full textSupplemental material, sj-pdf-1-pie-10.1177_09544089221077661 for Influence of rotation speeds on microstructure and mechanical properties of welded joints of friction stir welded AA2014-T6/AA6061-T6 alloys by T Ramkumar, A Haiter Lenin, M Selva kumar, M Mohanraj, S Christopher Ezhil Singh and M Muruganandam in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering</p
THE INHIBITION AND ADSORPTION PROPERTIES OF DTPMP TSC ON STAINLESS STEEL IN ACIDIC MEDIUM
No full textThe inhibition effect of diethylenetriamine penta(methylene phosphonic acid) (DTPMP) and Trisodium Citrate (TSC) on thecorrosion behavior of stainless steel in 0.5 M H2SO4 solution was investigated by using weight loss method. The combinedcorrosion inhibition efficiency offered 200 ppm of DTPMP and 150 ppm of TSC was 95%. Polarization study showed thatthe inhibitors inhibit stainless steel corrosion through mixed mode and electrochemical impedance spectroscopy (EIS)results confirm the adsorption of the inhibitors at stainless steel/acid interface. The adsorption of DTPMP and TSC ontothe stainless steel surface was found to follow Langmuir adsorption isotherm modes. Negative values of (ΔGads) in theacid media ensured the spontaneity of the adsorption process. The nature of the protective film formed on the metalsurface has been analyzed by FTIR spectra, SEM and AFM analysis. The activation energy (Ea), free energy change(ΔGads), enthalpy change (ΔHads) and entropy change (ΔSads) were calculated to understand the corrosion inhibitionmechanism
Population Pharmacokinetic Analysis of Centrally Acting Drugs Metabolized by CYP2D6
No full textA simple, sensitive, and reliable UPLC method has been developed and validated for simultaneous determination of risperidone, 9-hydroxyrisperidone and olanzapine in human plasma in vitro.
• The developed method has been successfully adopted to evaluate the pharmacokinetic parameters of second generation antipsychotic drugs, risperidone and its major metabolite, 9-hydroxyrisperidone, in human plasma.
• The distributions of normal, intermediate and poor metabolizers were found to be 70%, 25% and 5% respectively. The allelic frequencies of all SNP were in Hardy-Weinberg equilibrium (P ≥ 0.05).
• The metabolic ratio was higher in intermediate metabolizers (2.04 ± 0.20) as compared to normal metabolizers (1.40 ± 0.22).
• The pharmacokinetic parameters (Cmax, AUC0-t, T1/2 and CL) of active moiety were found to be significant in normal and intermediate metabolizers.
• Poor metabolizers exhibited a higher prevalence of CNS (P = 0.001), CVS (P < 0.001), dizziness (P = 0.005), hypotension (P = 0.01) and GIT (P = 0.01) as compared to normal metabolizers.
• Our data supports these above conclusions in our sample population, i.e., poor metabolizers require half the risperidone dose than that for normal metabolizers to reduce the incidence of adverse effects.
CONCLUSION:
In the current study, we have demonstrated significant association between the genotype status and pharmacokinetic parameter of normal subjects from our locale in South India with respect to the CYP2D6*10 genotype. Our data suggest that CYP2D6*10 polymorphism have significant association between risperidone and 9-hydroxyrisperidone pharmacokinetics. Active moiety is highly predictive of the clinical response to risperidone in healthy volunteers, which is dependent on the CYP2D6*10 genotype status. Additionally, we demonstrated that using NONMEM and multi-compartment mixed effect modelling of the population pharmacokinetics of risperidone and its metabolite, genotype has a major influence on determining the plasma concentrations of both risperidone and 9- hydroxyrisperidone. The pharmacogenetic variations in clearance of the risperidone and 9-hydroxyrisperidone may be due to differential expressions of CYP2D6 in intestinal epithelium in different genotypes of CYP2D6*10 allele. Further, this could be applied to clinical decision making such as determination of dosing intervals. We recommend that the dose of risperidone in slow metabolizers must be less that used in normal metabolizers, though it has to be confirmed in further studies in our population
A study on Hypophosphatemia in critically ill patients in ICU its incidence and predictors in Thanjavur Medical College Hospital
No full textBACKGROUND:
Hypophosphatemia is one of the common disorders that develop in critically ill patients. It has potential complications and is often unnoticed in them.
OBJECTIVE:
Determining the incidence of hypophosphatemia in critically ill patients, its association with clinical outcomes and the possible risk factors.
METHODS:
50 patients were enrolled in this single centred prospective study, over a period of 6 months. Levels of serum phosphate were measured randomly during their ICU stay. The following variables were analysed: age, gender, diagnosis on
admission, use of dopamine, furosemide, steroids, dextrose intake, insulin, serum levels of phosphorous, calcium, liver function tests, renal function tests, number of days of mechanical ventilation and mortality.
RESULTS:
The incidence of hypophosphatemia was 8%. All of them were on mechanical ventilators. Association between hypophosphatemia and COPD (P value = 0.02),
liver disease was statistically significant. (P value = 0.005). Correlation between the incidence of hypophosphatemia and mechanically ventilated patients was statistically significant (P value = 0.03). Statistically significant mortality rate was associated with
hypophosphatemia.
CONCLUSION:
In a critically ill-patients, Hypophosphatemia is a predictor of respiratory failure and mortality. So some place should be reserved for serum phosphate levels in
ICU blood investigation panels
SAMPLING AND ANALYSISING OF DISSOLVED OXYGEN IN WATER SAMPLES COLLECTED AT SUNDARAPURAM IN COIMBATORE DISTRICT
No full textMaintenance of dissolved oxygen at saturated level will help the growth and reproduction of normal population of fish and other aquatic organisms1,2. Due to increase of industries, it is necessary to monitor the DO level of water resources. This will help us to understand the present condition of water at various resources that are connected to the industries. In this study the water is collected from various resources around Sundarapuram in coimbatore district and they were subjected to dissolved oxygen study. The DO results of various samples were compared with DO of demineralised water which is taken as reference. Parameters such as temperature, hardness and aeration time that will affect the saturation level of DO are also discussed 6,7,8.Â
Comportamento organizacional em ambiente de mundanças: o caso do Instituto de Pesquisa e Planejamento Urbano de Curitiba
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Sócio-Econômico. Programa de Pós-Graduação em Administração.Este trabalho foi elaborado para caracterizar o comportamento organizacional diante das mudanças ocorridas no Instituto de Pesquisa e Planejamento Urbano de Curitiba - IPPUC. O estudo decorre do destaque internacional do Instituto, que apesar dos percalços da atividade pública, continua a sua trajetória rumo a excelência do planejamento urbano. A análise objetivou: identificar as alterações organizacionais ocorridas no IPPUC entre 2000 e 2002; identificar a fundamentação teórica que melhor explica a construção organizacional do IPPUC; e finalmente, identificar os principais traços do comportamento organizacional em um ambiente de mudanças. Em última instância, identificar as características que distinguem o Instituto quanto à capacidade de elaboração de propostas inovadoras e também pelas características empíricas que possibilitam associá-lo aos Sistemas Organizacionais de Alto Desempenho - STAD. A pesquisa de cunho qualitativo foi aplicada a uma amostra proposital, composta por integrantes chaves. A análise dos dados ocorreu de forma matricial, a partir de uma abordagem multidimensional, comparando as respostas dos níveis institucional, gerencial e operacional, com os elementos teóricos que compõem a organização: nível individual, grupal e de sistemas; que interagem com a estrutura: tecnologia, ambiente e estratégias e, finalmente, com as forças para mudanças que são: os interesses pessoais, a percepção e a cultura da organização
To identify novel oncogenes for the design of novel tools for diagnosis and treatment of cancer
No full textCancer is a disease caused by an uncontrolled cell growth that destroys the healthy tissue of the body. It is one of the deadliest diseases in the world that alters many cellular mechanisms and features. In this report, a list of 22 upregulated oncogenes is studied to identify the novel oncogene. The need to determine the novel oncogene is to develop the anti-cancer agent. To determine the novel oncogene, gene enrichment analysis (GEA) was performed. It is a method to identify classes of genes that are over-represented in the large set of genes to determine the phenotypes of the organisms. DAVID and PANTHER are the methods used to carry on this study as it has Gene Ontology (GO) embedded in it. The GEA uses fishers exact test to determine the enriched gene by the standard p-value of 0.05. To further study the oncogene Network Enrichment Analysis was performed with EVINET. We found that microtubule was significantly enriched in NEA. The genes significantly enriched for GO microtubule were studied. The significantly enriched microtubule in NEA might then be used as a target for anti-cancer agent and used to develop the drug in the future
A Study on Utilization of Information and Communication Technology By the Users of University Libraries in Tamilnadu, India
No full textAcademic libraries in the modern era are developing in every aspect of the information management processes with the help of increasing and innovative utility of modern technologies. The use of Information Communication Technology (I CT) in academic libraries helps both the library staff and the users in many ways in terms of accuracy, time, labor, space, and money to some extent. Generally, I CT deals with all the uses of digital technology, which already exist to help individuals, businesses and organisations for using information. The study conducted to investigate how university students and teachers communicate using various communication media and Information & Communication Technology in the study and teaching, Also analyses the implications of these choices on user’s outcomes, which are comprised of satisfaction with the process, satisfaction with performance. This paper makes an attempt to understand the concept of I C T and to explore its varied applications in academic libraries
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