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Effect of water on the physical and chemical properties of end-capped poly(d,l-lactide-co-glycolide)
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Effect of agitation regimen on the in vitro release of leuprolide from PLGA microparticles
No full textDue to the importance of in vitro release tests in establishing batch-to-batch reproducibility and in vitro/in vivo correlation, this study investigated the influence of the agitation regimen on the in vitro release behavior of leuprolide from PLGA microparticles. Leuprolide loaded microspheres were prepared using Resomer® RG502H and RG503H as polymers. Leuprolide in vitro release was performed in phosphate buffer solution under continuous or once-a-week agitation. At predetermined intervals, leuprolide release, polymer mass loss (ML), and degree of hydration (DH) were investigated. Leuprolide release and ML were higher under continuous agitation with respect to that under intermittent agitation. Using a modified version of Koizumi equation, it was possible to fit leuprolide release profiles. f2 comparison showed a high level of similarity between experimental and modeled data in the case of once-a-week agitation regimen. This work highlights the importance of the in vitro release conditions on peptide release behavior from polyester microparticles
Evaluation of abrasive agents on the in vitro and chew-out release of a decapeptide from a chewing gum formulation
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Analysis of Accelerated In Vitro Release Profiles For PLA Microspheres Loaded with an LHRH Antagonist Decapeptide
No full textStudy of release profiles of an LHRH antagonist decapeptide from PLA microspheres under accelerated conditions
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