1,721,023 research outputs found
Presupposti ed evoluzione dell’implantologia post-estrattiva
No full textScopo del lavoro. La perdita dell’elemento dentale determina il riassorbimento dell’osso alveolare, rapido entro i primi 3 mesi e più lento per tutta la vita. L’inserimento di impianti in siti postestrattivi immediatamente dopo l’avulsione elimina il riassorbimento e riduce il tempo di trattamento. Nel presente lavoro, gli autori si propongono di apportare un piccolo contributo sulla base della loro esperienza per confermare la possibilità di ottenere un’osteointegrazione adeguata con l’inserimento di impianti nel sito postestrattivo. Per migliorare l’adattamento, nel secondo caso è stato usato un impianto di nuova generazione a forma radicolare. Materiali e metodi. Nel primo caso clinico sono stati estratti 2 molari nel primo quadrante per motivi parodontali e sostituiti con 2 impianti avvitati di forma cilindrica. Nel secondo caso, il centrale superiore di sinistra fratturato è stato estratto e sostituito con un impianto a forma radicolare. Le discrepanze tra sito alveolare postestrattivo e superficie implantare sono state colmate con osso autologo ed eterologo. Dopo 4 mesi, gli impianti integrati, dal punto di vista clinico e radiologico, sono stati protesizzati. Risultati e conclusioni. Le percentuali di successo dell’implantologia tradizionale e di quella postestrattiva sono sovrapponibili e l’integrazione si ottiene a patto che venga eliminato adeguatamente il tessuto infiammatorio e garantita una buona stabilità primaria
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
How different water activities affect rice germ shelf-life: an aquaphotomics approach
No full textThe aim of this study is to investigate how different water activities affect rice germ shelf life. In fact, this matrix (a by-product of rice milling process) could be interesting for human nutrition but, for its composition characterized by unsaturated fatty acids, it undergoes rancidity during storage. Dried samples at different water activities (0.55, 0.45 and 0.36) were packed in air and stored at 27°C for 320 days (for a total of 7 sampling points). All the samples were analysed by FT-NIR spectroscopy in reflectance (in the 800 – 2780 nm spectral range) with a rotating sample holder, as a non-targeted analytical approach.
First of all, focusing on the Aquaphotomics approach, spectral analysis was done in the water first overtone range, 1300 and 1600 nm; then an exploratory principal component analysis (PCA) was performed, followed by a partial least squares regression method (PLSR) to understand the NIR spectral changes that characterize the differences caused by different water activity levels in rice germ during storage. In more depth, four wavelengths, essential for the description of this system, were found to define the so called water matrix coordinates (WAMACS): 1343 nm, associated with protonated water, 1392 nm, typical absorbance of trapped water, 1410 nm, the well-known band of free water and 1436 nm, the Zundel cation band (H5O2 + ) and the respective WAter Spectral Patterns, WASP. Radial graphics of the normalised WAMACS absorbance values were built: such Aquagrams allow to understand the modification of different water molecular the structures along time, for each water activity under investigation.
Thanks to this state-of-the-art approach, the water molecular conformation changes related to different water activities in rice germ along the storage were discovered. These findings will open the venue of understanding the water molecular structure behind water activity in general.
Acknowledgment: the authors thank ‘Rondolino - Società Cooperativa Agricola’ for samples supply and economic support
Molecular characterization of skeletal regeneration in the brittle star amphiura filiformis
No full textEchinoderms are well known for their extensive regenerative abilities, but have been neglected in the field due to the lack of available molecular tools and resources [1]. Recently, developmental [2] and adult transcriptomes [3, 4] of the brittle star Amphiura filiformis have been sequenced, which opened up this species for molecular investigations of its rapid arm regeneration process. We use this brittle star as a model to understand the cellular and molecular aspects of skeletogenesis during adult arm regeneration and the potential role of the FGF signalling pathway in this process. Ultimately, we compare the molecular network driving regeneration of the skeleton to that underlying embryonic skeleton development [5].
Following a characterization of the anatomy and development of the skeleton during arm regeneration in A. filiformis [6], we established methods for spatio-temporal expression analysis [7] and pharmacological treatments to characterise genes involved in adult arm regeneration. We found that 18 embryonic skeletogenic mesoderm genes (transcription factors, signaling receptors and downstream differentiation genes) are also expressed in the dermal layer of the adult regenerating arm, where skeletal spicules form. FGF signalling perturbation using the SU5402 inhibitor interferes with skeleton formation during both embryonic development and adult regeneration of this brittle star. A large-scale comparison of genes affected by SU5402 in adult arm regeneration and during embryonic development revealed a conservation of network components downstream of FGF signalling between those two developmental modes.
Acknowledgements: We thank the staff at the Sven Lovén Centre for Marine Sciences in Kristineberg, especially Olga Ortega-Martinez and Sam Dupont, for assistance during animal and sample collection.
References:
1. Dupont S, Thorndyke M (2007) Bridging the regeneration gap: insights from echinoderm models. Nat Rev Genet 8:8–10
2. Delroisse J, Ortega-Martinez O, Dupont S, Mallefet J, Flammang P (2015) De novo transcriptome of the European brittle star Amphiura filiformis pluteus larvae. Mar Genomics. doi: 10.1016/j.margen.2015.05.014
3. Purushothaman S, Saxena S, Meghah V, Swamy CVB, Ortega-Martinez O, Dupont S, Idris M (2014) Transcriptomic and proteomic analyses of Amphiura filiformis arm tissue-undergoing regeneration. J Proteomics 1–12
4. Delroisse J, Mallefet J, Flammang P (2016) De Novo Adult Transcriptomes of Two European Brittle Stars: Spotlight on Opsin-Based Photoreception. PLoS One 11:e0152988
5. Dylus DV, Czarkwiani A, Stångberg J, Ortega-Martinez O, Dupont S, Oliveri P (2016) Large-scale gene expression study in the ophiuroid Amphiura filiformis provides insights into evolution of gene regulatory networks. Evodevo 7:2
6. Czarkwiani A, Ferrario C, Dylus D V., Sugni M, Oliveri P (2016) Skeletal regeneration in the brittle star Amphiura filiformis. Front Zool 13:18
7. Czarkwiani A, Dylus D V., Oliveri P (2013) Expression of skeletogenic genes during arm regeneration in the brittle star Amphiura filiformis. Gene Expr Patterns 13:464–47
Total Hepatitis B Core Antigen Antibody, a Quantitative Non-Invasive Marker of Hepatitis B Virus Induced Liver Disease.
No full textNon invasive immunologic markers of virus-induced liver disease are unmet needs.
We tested the clinical significance of quantitative total and IgM-anti-HBc in
well characterized chronic-HBsAg-carriers. Sera (212) were obtained from 111
HBsAg-carriers followed-up for 52 months (28-216) during different phases of
chronic-HBV-genotype-D-infection: 10 HBeAg-positive, 25 inactive-carriers
(HBV-DNA≤2000IU/ml, ALT<30U/L), 66 HBeAg-negative-CHB-patients and 10 with
HDV-super-infection. In 35 patients treated with Peg-IFN±nucleos(t)ide-analogues
(NUCs) sera were obtained at baseline, end-of-therapy and week-24-off-therapy and
in 22 treated with NUCs (for 60 months, 42-134m) at baseline and
end-of-follow-up. HBsAg and IgM-anti-HBc were measured by Architect-assays
(Abbott, USA); total-anti-HBc by double-antigen-sandwich-immune-assay (Wantai,
China); HBV-DNA by COBAS-TaqMan (Roche, Germany). Total-anti-HBc were detectable
in all sera with lower levels in HBsAg-carriers without CHB (immune-tolerant,
inactive and HDV-superinfected, median 3.26, range 2.26-4.49 Log10 IU/ml) versus
untreated-CHB (median 4.68, range 2.76-5.54 Log10 IU/ml), p<0.0001. IgM-anti-HBc
positive using the chronic-hepatitis-cut-off" (0.130-S/CO) were positive in 102
of 212 sera (48.1%). Overall total-anti-HBc and IgM-anti-HBc correlated
significantly (p<0.001, r=0.417). Total-anti-HBc declined significantly in CHB
patients with response to Peg-IFN (p<0.001) and in NUC-treated patients
(p<0.001); the lowest levels (median 2.68, range 2.12-3.08 Log10 IU/ml) were
found in long-term responders who cleared HBsAg subsequently. During spontaneous
and therapy-induced fluctuations of CHB (remissions and reactivations) total- and
IgM-anti-HBc correlated with ALT (p<0.001, r=0.351 and p=0.008, r=0.185
respectively). Total-anti-HBc qualifies as a useful marker of
HBV-induced-liver-disease that might help to discriminate major phases of chronic
HBV infection and to predict sustained response to antivirals
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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