579 research outputs found
Development, evaluation and utilization of in vitro models in the investigation of nephropathic cystinosis.
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82004.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 28 september 2010Promotores : Heuvel, L.P.W.J. van den, Levtchenko, E.N. Co-promotor : Masereeuw, R.207 p
Molecular analysis of podocyte genes in nephrotic syndromes.
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76504.pdf (Publisher’s version ) (Open Access)RU Radboud Universiteit Nijmegen, 06 april 2010Promotor : Heuvel, L.P.W.J. van den Co-promotores : Groenen, P.J.T.A., Levtchenko, E.N.135 p
neonatal creatinemia trends as biomarker of subsequent cognitive outcome in extremely low birth weight neonates
No full textBACKGROUND AND AIMS: Serum creatinine is traditionally used as a marker of renal function in neonates and relates to gestational age and disease severity in extremely low birth weight (ELBW) infants. Creatinine is commonly used as a biomarker for early morbidity, but we aim to compare postnatal creatinemia trends as a biomarker for subsequent cognitive outcome. We hypothesize that impaired microcirculation not only in the kidney, but also in general (i.e. brain development) can explain this possible link. STUDY DESIGN AND OUTCOME MEASURES: A cohort of ELBW infants was analyzed by Bayley Scales of Infant Development (BSID-II) at the corrected age of 2years old. Besides other perinatal indicators, neonatal creatinemia trends of survivors (n=140) and BSID scores (n=96) are compared and analyzed using optimal matching analysis. Hierarchical clustering analysis is applied to identify createnimia trends. RESULTS: Four different creatinemia trends were identified (persistently high, normal, low, high but normalizing). A low creatinemia trend is significantly associated with the lowest percentages of postnatal corticosteroids, NSAIDS and intraventricular hemorrhage (p=0.005, p=0.013 and p=0.041 respectively) compared to a normal or persistently high creatinemia trend and associated with the best cognitive outcome (+13 points compared to the mean creatinemia trend and +23 points compared to a persistently high creatinemia trend). CONCLUSIONS: Creatinemia trends after birth are not only useful to predict renal function, but are also associated with cognitive outcome in extremely low birth weight infants. Neonates who have low creatinemia trends after birth, have the highest BSID scores at the age of two years old.sponsorship: All authors have approved the final article. Karel Allegaert and Elena Levtchenko are senior clinical investigators of the Fund for Scientific Research, Flanders (fundamental clinical investigator ship 1800214N and 1801110N respectively). Elena Levtchenko is supported by the EURenOMICS consortium, grant agreement 305608. This study was supported by the "Agency for Innovation, Science and Technology in Flanders (IWT) through the "SAFEPEDRUG" project (IWT/SBO 120033). (Fund for Scientific Research, Flanders|1800214N, Fund for Scientific Research, Flanders|1801110N, EURenOMICS consortium|305608, Agency for Innovation, Science and Technology in Flanders (IWT)|IWT/SBO 120033)status: Publishe
Evidence of non-Dzyaloshinskii–Moriya ferromagnetism in epitaxial BiFeO3 films
No full textX-ray diffraction analysis and high-resolution electron microscopy of BiFeO3 films prepared by dc magnetron sputtering on single-crystal LaAlO3 (001) substrates reveal that the films have a highly c-oriented orthorhombic crystalline structure. The magnetic properties of the BiFeO3 films are typical of ensembles of interacting superparamagnetic clusters, rather than Dzyaloshinskii-Moriya weak ferromagnets. The appearance of extrinsic nanoscale superparamagnetic clusters is explained by an oxygen deficiency in certain regions of the film, where ferromagnetic ordering can be realized through a double-exchange Zener mechanism.Applied Science
Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia
No full textHaffner, D., Emma, F., Eastwood, D.M., Duplan, M.B., Bacchetta, J., Schnabel, D., Wicart, P., Bockenhauer, D., Santos, F., Levtchenko, E., Harvengt, P., Kirchhoff, M., Di Rocco, F., Chaussain, C., Brandi, M.L., Savendahl, L., Briot, K., Kamenicky, P., Rejnmark, L., Linglart, A
Two-dimensional growth, anisotropic polaron transport, and magnetic phase segregation in epitaxial Nd0.52Sr0.48MnO3 films
No full textNd0.52Sr0.48MnO3 films have been fabricated by dc magnetron sputtering on single-crystal LaAlO3 (001) and SrTiO3 (011) substrates with additional annealing to relax the lattice strain. Although the Nd0.52Sr0.48MnO3 films were deposited simultaneously on different substrates at the same deposition rate, they differ in thickness by a factor of ? . The observed difference in thickness is explained by the two-dimensional (layer-by-layer) film growth, rather than by a difference in growth rate controlled by the crystalline orientation of the substrate. An analysis of optical and transport properties reveals that the observed anisotropy in the polaron motion is governed by a strong anisotropy in the trapping energy, rather than in polaron formation. It is shown that the deposited Nd0.52Sr0.48MnO3 films exhibit magnetic behavior typical of two-phase magnetic systems and should be regarded as an assembly of interacting magnetic clusters.Applied Science
Creatinaemia at birth is equal to maternal creatinaemia at delivery: does this paradigm still hold?
No full textOBJECTIVE: The paradigm that creatinaemia at birth is equal to maternal creatinaemia may also depend upon the quantification technique applied. Paired maternal-neonatal creatinaemia samples in whom Jaffe in both or compensated Jaffe (maternal) and enzymatic quantification (neonate) were applied. METHODS: Extreme low birth weight infants in two time intervals were included when paired maternal-neonatal creatinaemia samples were available. In cohort 1 (2000-2005), creatinaemia (mothers and neonates) was based on Jaffe assay. In cohort 2 (2007-2010), maternal creatinaemia was based on compensated Jaffe. In neonates, an enzymatic technique was applied. Unpaired Mann Whitney U, paired Wilcoxon and Bland-Altman were used. RESULTS: Based on 80 and 52 paired creatinaemia samples, there was no significant difference between maternal (0.80, 0.41-1.6 mg.dl(-1)) and neonatal creatinaemia (0.78, 0.31-1.46 mg.dl(-1)) in cohort 1 while a significant difference (p < 0.001) between maternal (0.6, 0.29-2.24 mg.dl(-1)) and neonatal creatinaemia (0.67, 0.4-2.2 mg.dl(-1)) was observed for cohort 2. Using Bland-Altman, the fit was perfect for cohort 1 (mean diff -0.02 mg.dl(-1)), but not for cohort 2 (-0.08 mg.dl(-1)). CONCLUSIONS: The quantification method affects the paradigm that creatinaemia at birth is similar to maternal creatinaemia. Maternal and neonatal creatinaemia values depend on the method used. Consequently, method-specific reference values are needed.sponsorship: Elena Levtchenko and Karel Allegaert are supported by the Fund for Scientific Research, Flanders (Belgium) (F.W.O. Vlaanderen) by a Fundamental Clinical Investigatorship (1801110N and 1800209N). (Fund for Scientific Research, Flanders (Belgium) (F.W.O. Vlaanderen), Fundamental Clinical Investigatorship|1801110N, Fundamental Clinical Investigatorship|1800209N)status: Publishe
Autophagy in renal diseases
No full textAutophagy is the cell biology process in which cytoplasmic components are degraded in lysosomes to maintain cellular homeostasis and energy production. In the healthy kidney, autophagy plays an important role in the homeostasis and viability of renal cells such as podocytes and tubular epithelial cells and of immune cells. Recently, evidence is mounting that (dys)regulation of autophagy is implicated in the pathogenesis of various renal diseases, and might be an attractive target for new renoprotective therapies. In this review, we provide an overview of the role of autophagy in kidney physiology and kidney diseases.sponsorship: Stephanie De Rechter and Elena Levtchenko are supported by the Fund for Scientific Research, Flanders 11M5214N, Fundamental Clinical Investigatorship 1801110N and has been supported by an IWT-SBO project (130033). Djalila Mekahli is supported by the Clinical Research Fund of UZ Leuven. Jean-Paul Decuypere is supported by a post-doctoral fellowship of ERA-EDTA. (Fund for Scientific Research, Flanders|11M5214N, Fundamental Clinical Investigatorship|1801110N, IWT-SBO project|130033, Clinical Research Fund of UZ Leuven, post-doctoral fellowship of ERA-EDTA)status: Publishe
Cystinosis: improved medical care and new insights into pathogenesis.
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49724.pdf (Publisher’s version ) (Open Access)RU Radboud Universiteit Nijmegen, 30 maart 2006Promotor : Monnens, L.A.H. Co-promotores : Blom, H.J., Heuvel, L.P.W.J. van den180 p
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