1,720,958 research outputs found
"Molecular screening of genetic defects with RNA-SSCP Analysis: the PKU and Cystinuria Model"
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Genotypic hetereogeneity of the molecular basis of cystic fibrosis: the paradigm of lithuanian population genetic testing
No full textSince cystic fibrosis (CF) is the most common lethal hereditary monogenic disease in Caucasian populations with an average prevalence of 1:2500 newborns, population screening by genetic testing for CF prenatal diagnosis and clinical phenotype determination seems worthwhile to implement in all countries as is the case for other common inherited disease screening protocols. Worldwide mutational analysis of the CF transmembrane regulator (CFTR) gene has revealed that p.F508del mutation accounts on the average for 70-80% of CF chromosomes from northern Europe and America. Yet, more than 1500 mutations of CFTR have been identified to cause CF in different populations. In addition, the phenotypic spectrum associated with mutations in the CFTR gene extends beyond the classically defined CF. Due to the high allelic and phenotypical heterogeneity of CF chromosomes, it is important to identify the CFTR mutation spectrum in specific populations to implement efficient molecular diagnostic protocols as well as to define a correct genotype-phenotype correlation. We have characterized the molecular basis of CF in Lithuania through the analysis of the CFTR gene in 98 unrelated chromosomes from 49 Lithuanian CF patients using both gene scanning and mutation screening methods. A CFTR mutation was characterized in 64.2% of CF chromosomes. The most frequent Lithuanian CF mutation is p.F508del (52.0%). Seven CFTR mutations, CFTRdele2,3(21 kb) (2.0%), p.N1303K (2.0%), p.R75Q (1.0%), p.G314R (1.0%), p.R553X (4.2%), p.W1282X (1.0%), and g.3944delGT (1.0%), accounted for 12.2% of Lithuanian CF chromosomes. Since standard PCR-based techniques did not allow us to characterize 35.8% of the CF Lithuanian chromosomes, we also analyzed three intragenic CFTR gene microsatellites, IVS8CA, IVS17bCA and IVS17bTA in the previously analyzed 49 Lithuanian patients as well as in their relatives for a total of 151 chromosomes (98 CF and 53 normal chromosomes). The most frequent CF haplotype 17-31-13 (21.4%) was shown to be the ancestral haplotype on which p.F508del mutation arose and, together with another 7 haplotypes, account for 67% of CF chromosomes. Haplotypes 16-30-13, 16-33-13, 16- 36-13, 17-31-11, 22-31-13 account for 10% of CF Lithuanian chromosomes with yet unidentified mutations and, with the exception of 16-30-13, were not found in normal chromosomes. Another 6 haplotypes (1% each) represent the remaining CF chromosomes characterized. Indirect linkage analysis to follow segregation of CF chromosomes using identified CFTR haplotypes revealed 82% informative families out of 22 families considered. Thus, screening of the eight CFTR disease-causing mutations, accounting for 64.2% of Lithuanian CF chromosomes, combined with haplotype linkage analysis in informative families, provide the basis for the implementation of clinical genetic testing of CF in Lithuania. The characterization of a comprehensive molecular epidemiology of CF in the Lithuanian population points to the importance of continuing to pursue small-scale genotyping research projects for reliable and efficient inherited disease genetic testing in clinical practice
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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