56 research outputs found
Clinical practice evaluation of combination of atosiban, ritodrine and ketoprofen for inhibiting preterm labor.
No full textMinerva Ginecol. 2007 Oct;59(5):481-9.
Clinical practice evaluation of combination of atosiban, ritodrine and ketoprofen for inhibiting preterm labor.
Grignaffini A, Soncini E, Ronzoni E, Lo Cane F, Anfuso S, Nardelli GB.
SourceDepartment of Gynaecology, Obstetrics and Neonatology, University of Parma, Parma, Italy.
Abstract
AIM: The aim of this study was to compare the efficacy and tolerability of atosiban vs ritodrine administered as single-drug or as combination therapy with the COX inhibitor ketoprofen in the treatment of preterm labor and to investigate how frequent is the need for combination therapy with ketoprofen.
METHODS: Ninety-one women with diagnosis of threatened preterm delivery at 24-33 weeks' gestation were enrolled in an observational case-control study. Forty-seven received IV atosiban (6.75 mg initial dose, 300 microg/min loading dose for 3 hours, 100 microg/min maintenance dose for 48-96 hours) and 44 IV ritodrine (0.05-0.3 mg/min). When response to the first drug in the first 2-4 hours was unsatisfactory, ketoprofen was added (100 mg loading dose IV and 100-150 mg maintenance dose every 12 hours) for a maximum of 48 hours.
RESULTS: Ketoprofen was added in 51.1% of the atosiban group and 47.7% of the ritodrine group (P 0.75, not statistically significant). The percentages of women non delivered in the two groups were 85.1% vs 81.8% at 48 hours (P=0.44) and 59.6% vs 54.5% at 7 days (P=0.39). One woman treated with atosiban reported transient dyspnea at the administration of the bolus dose; 20.5% of women who received ritodrine developed tachycardia and 4.5% dyspnea (P=0.001). Neonatal mortality and morbidity were comparable in both groups and unrelated to ketoprofen exposure.
CONCLUSION: Atosiban efficacy was comparable to ritodrine, but with a superior safety profile. A large proportion of women in both groups required second-line ketoprofen therapy, with comparable neonatal outcome
Linee guida per la gravidanza fisiologica. Gruppo di studio AUSL di Parma, Azienda Ospedaliera di Parma, Università degli Studi di Parma. Atti ufficiali del convegno. Parma 25/2/2002
No full textHIV e gravidanza: una sfida in continua evoluzione. Atti del congresso tenuto a Parma l’1/12/2001
No full text
Eccezione, eccesso, eccezionalità. 24 e la war on terror
No full textL'articolo analizza la serie televisa americana "24", prodotta dalla Fox e distribuita in tutto il mondo con un enorme successo. A partire da una descrizione semiotica del suo format, dal modo in cui viene trattato il piano dell'espressione fino ai temi toccati dalla serie, si cerca di far emergere come questa fiction traduce e ri-presenta temi scottanti dell'attualità: il terrorismo, la paura, le minacce alla sicurezza nazionale. In particolare, e anche grazie ai suo "eccessi" stilistici e tematici, "24" permette di riflettere sul modo in cui oggi si può mostrare, e anche parlare, di tortura, dei modi in cui è legittimata, oltre che messa in scena
Nose defects reconstruction with the Zitelli bilobed flap
No full textThe skin Cancers of the head and neck district are localized mostly on the nose, which, by being in the center of the mid-face, has an important aesthetic role. Therefore, many reconstructive techniques have been studied; among them regional skin fiaps appeared the most suitable since they guaranteed the oncological radicality as well as a good aesthetic outcome. In this paper, we present our experience with the use of the Zitelli bilobed flap, which is defined as a double transposition flap for the reconstruction of the nose defects. From 2008 to 2012, we have treated 86 patients (56 men and 30 women, aged between 47 and 83 years) for skin Cancer of the nose (72% basal-cell Carcinoma, 28% squamous cell Carcinoma); for all patients, the nose defects' reconstruction was performed by means of the modified Zitelli bilobed flap. The results were evaluated by short- and long-term follow-up; no infections or major complication were reported, while high preservation of the patient's facial characteristics and normal functions of the nose were observed. In 12 cases, little distortions of the alar rim were recorded although these patients still evaluated the cosmetic outcome as good. In our experience, the Zitelli bilobed flap remains a robust and reliable tool for the reconstruction of the nose defects, since it preserves its function, while ensuring a good aesthetic result
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