1,721,010 research outputs found
The prognostic value of F-18 fluorodeoxyglucose bone marrow uptake in patients with recent diagnosis of multiple myeloma : a comparative study with Tc-99m sestamibi
No full textPurpose: We assessed the prognostic value of F-18 fluorodeoxyglucose (FDG) uptake in the bone marrow of patients with multiple myeloma (MM) in comparison with Tc-99m methoxy-isobutyl-isonitrile (MIBI). Methods: The extent and intensity of FDG and MIBI uptake in the bone marrow of 18 patients with a recent diagnosis of MM were assessed by visual score and by calculating the mean SUV (mSUV) for FDG and the femora/thigh ratio (TG/BKG, [Target/Background ratio]) for MIBI images. These parameters were correlated with clinical indexes of disease using hemoglobin and beta-2-microglobulin levels and plasma cell infiltrate (PCI) percentage. The mean values of the visual score, mSUV, and TG/BKG levels were compared in patients deceased after a relatively short follow-up (n = 9; group A) and in patients with a longer survival or were alive at the end of the study (n = 9; group B). Results: Significant correlations of mSUV and TG/BKG values with PCI percentages and beta-2-microglobulin were found (P < 0.05). The extent of FDG and MIBI bone marrow uptake was greater in patients of group A (P < 0.01). Higher values of mSUV (P < 0.01) and TG/BKG (P < 0.05) were also observed in patients of group A. These results were consistent with the differences (not statistically significant) in hemoglobin, albumin, beta-2-microglobulin levels, and PCI percentages observed in the 2 groups. Conclusion: Our study demonstrates that an increase of FDG bone marrow uptake may predict a more aggressive disease, as much as MIBI uptake. Therefore, an additional analysis of FDG bone marrow images should be performed in patients undergoing PET studies during the initial staging of MM
Improving PET image spatial resolution by experimental measurement of scanner blurring properties
No full textRole of Tc-99m sestamibi scintigraphy in the diagnosis and surgical decision-making process in primary hyperparathyroid disease
No full textUltrasound (US) and scintigraphy are used most frequently of all the available imaging techniques for the preoperative evaluation of patients with possible primary hyperparathyroid disease. The aim of this study was to assess the value of dual-phase Tc-99m MIBI scintigraphy compared with US in the detection of adenomatous or hyperplastic glands and in the surgical decision-making process for patients with a biochemical diagnosis of primary hyperparathyroid disease
Preliminary clinical validation of an algorithm for the quantification of 18F-FDG uptake for pulmonary lesions in PET-CT
No full textValidity and reliability of a gel-coupled ultrasound scanning system in measuring bone mass in healthy subjects
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Utilità dell'osteoprotegerina (OPG) sierica quale marker di efficacia della terapia nel morbo di Paget osseo
No full textValidity and reliability of a gel-coupled ultrasound scanning system in assessing bone mass in healthy subjets
No full textTo determine the reliability and validity of a new ultrasound bone densitometry instrument, we studied 41 healthy volunteers (27 females and 14 males, mean age 33.8 yrs, range 22-45 yrs), who underwent ultrasound measurements with QUS-2 (Metra Biosystems Instrument [Quidel]). The measurements were repeated three times in the same visit (mean coefficient of variation 3.4%, range 0.64-10.87%). Fifteen of these subjects repeated the three measurements in two subsequent visits, 7 days apart from each other. There was a significant variability between subjects (p = 0.0001) and within subjects (p = 0.004). To compare the measurement performed with the new equipment with that of the gold standard, 19 subjects underwent a bone mass measurement by dual X-ray photon absorptiometry (DXA, Hologic QDR 4500A). The broadband ultrasound attenuation correlated with the total femur and femoral neck bone mineral density (r = 0.61, p = 0.005; r = 0.4, p = 0.09, respectively), but not with lumbar spine r = 0.34, p = 0.15). The mean coefficient of variation of the three ultrasound measurements performed in each of the subjects was 3.4% (range 0.64-10.87%). QUS-2 Metra Biosystems ultrasound densitometer does not seem at the moment a useful tool to assess bone mass in clinical setting, because of its high coefficient of variation and its high intra- subject variabilit
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