1,721,372 research outputs found
MICROCHIPS AND CLINICAL PRACTICE.
No full textMicroarrays have revolutionized molecular biology and medicine, with thollsands of hybridizations run and aliknown messengers of an organism studied togethel; instead of one gene and one messenger at a time. Major applicationsof microarray technology so far proposed refer to: a) genotyping, i.e. the definition of a specific genotype bydirect detection of known mutations/polymorphisms; b) gene expression and discovery, i.e. in order to simply answer the following question «which genes are expressed and to what extent ?» Specific applications include: a) predicting gene function, on the basis of specific expression patterns; b) linking celi pathways; c) «fingerprinting» of cellular or disease phenotype; d) drug discovery and drug target validation.At the present review we will give attempt to update the reader on the possible and practical use of microarraytechnology in clinical practice
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Vestibular and hearing loss in genetic and metabolic disorders.
No full textHearing loss affects about 4% of people under 45 years of age and comprises a broad spectrum of clinical presentations (congenital or late-onset, conductive or sensorineural, and syndromic or nonsyndromic). Approximately 30% of genetically determined deafness is reported to occur in syndromic form and 70% in nonsyndromic form. This review highlights recent advances in the molecular and genetic basis of hearing loss, which will help in understanding the biology of normal and abnormal hearing
Resilience and sustainability in relation to natural disasters: a challenge for future cities
No full textThe number of megacities worldwide is rapidly increasing and contemporary cities are also expanding fast. As a result, cities and their inhabitants are becoming increasingly vulnerable to the effects of catastrophic natural events such as extreme weather events (recently more frequent and intense as a result of the ongoing climate changes), earthquakes, tsunamis or man-induced events such as terrorist attacks or accidents. Furthermore, due to increasing technological complexity of urban areas, along with increasing population density, cities are becoming more and more risk attractors.
The resilience of cities against catastrophic events is a major challenge of today. It requires city transformation processes to be rethought, to mitigate the effects of extreme events on the vital functions of cities and communities. Redundancy and robustness of the components of the urban fabric are essential to restore the full efficiency of the city's vital functions after an extreme event has taken place. These items were addressed by an interdisciplinary and international selection of scientists during the 6th UN-World Urban Forum that was held in Naples, Italy in September 2012.
This volume represents in six chapters the views from sociologists, economists and scientists working on natural risk and physical vulnerability on resilience and sustainability for future cities in relation to natural disasters
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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