252 research outputs found
La previsione della domanda di mobilità per la progettazione e gestione delle infrastrutture viarie
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Thyroid dysfunctions secondary to cancer immunotherapy
No full textBackground: Immunotherapy is a firmly established pillar in the treatment of cancer, alongside the traditional approaches of surgery, radiotherapy, and chemotherapy. Like every treatment, also cancer immunotherapy causes a diverse spectrum of side effects, collectively referred to as immune-related adverse events. Objective: This review will examine the main forms of immunotherapy, the proposed mechanism(s) of action, and the incidence of thyroid dysfunctions. Methods: A comprehensive MEDLINE search was performed for articles published up to March 30, 2017. Results: Following the pioneering efforts with administration of cytokines such as IL-2 and IFN-g, which caused a broad spectrum of thyroid dysfunctions (ranging in incidence from 1 to 50%), current cancer immunotherapy strategies comprise immune checkpoint inhibitors, oncolytic viruses, adoptive T-cell transfer, and cancer vaccines. Oncolytic viruses, adoptive T-cell transfer, and cancer vaccines cause thyroid dysfunctions only rarely. In contrast, immune checkpoint blockers (such as anti-CTLA-4, anti-PD-1, anti-PD-L1) are associated with a high risk of thyroid autoimmunity. This risk is highest for anti-PD-1 and increases further when a combination of checkpoint inhibitors is used. Conclusions: Cancer patients treated with monoclonal antibodies that block immune checkpoint inhibitors are at risk of developing thyroid dysfunctions. Their thyroid status should be assessed at baseline and periodically after initiation of the immunotherapy
Circadian variations of prolactine (PRL), thyreotropic hormone (TSH), adrenocorticotropic hormone (ACTH) and cortisol (CS) in the chronic fatigue syndrome (CFS).
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Polyglandular autoimmune diseases in a dermatological clinical setting: vitiligo-associated autoimmune diseases.
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Tests of SEU effects of circuits developed in 130 nm CMOS technology
No full textTwo circuits have been studied for Single Event Upset (SEU) effects: ToPix4 (Torino Pixel) and the GBLD (GigaBit Laser Driver). The first one is the 4th generation custom prototype developed for the readout of the silicon pixel devices for the Micro Vertex Detector [1] of the PANDA [2] experiment. INFN, specifically the Sezione of Torino, is the leader of the development of this ASIC. The second one is part of the GBT project developed at CERN for the data transmission on optical links. It controls the laser diode that drives the optical fiber. INFN Torino department is involved in the design of this specific chip. Both ASICS are developed in a 130 nm CMOS technology and SEU protection techniques are applied to the digital part
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