505 research outputs found
Supplemental_Material_2 - Chinese Herbal Medicine Versus Other Interventions in the Treatment of Type 2 Diabetes: A Systematic Review of Randomized Controlled Trials
No full textSupplemental_Material_2 for Chinese Herbal Medicine Versus Other Interventions in the Treatment of Type 2 Diabetes: A Systematic Review of Randomized Controlled Trials by Ao Yu, David Adelson, and David Mills in Journal of Evidence-Based Integrative Medicine</p
Supplementary_Table - Chinese Herbal Medicine Versus Other Interventions in the Treatment of Type 2 Diabetes: A Systematic Review of Randomized Controlled Trials
No full textSupplementary_Table for Chinese Herbal Medicine Versus Other Interventions in the Treatment of Type 2 Diabetes: A Systematic Review of Randomized Controlled Trials by Ao Yu, David Adelson, and David Mills in Journal of Evidence-Based Integrative Medicine</p
Professor David Adelson
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Professor Adelson&#39;s research interests are genome evolution and architecture of mammals. Biological mechanisms underlying genome evolution are believed to originate with retrotransposon insertions that can ultimately lead to segmental (gene) duplications/deletions, incorporation of retrotransposons into protein coding genes (exaptation) or gene duplication via retro-gene formation. The resulting &quot;churning&quot; of both non-protein coding regions and protein domains are believed to be two of the major forces that drive speciation and adaptation. Current primary research aim is to understand the magnitude and rate of change associated with retrotransposon insertion.&nbsp;</p>
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This is an important research problem both in terms of our understanding of evolutionary mechanisms and processes but also because these processe frequently give rise to mutations or structural variation affecting gene regulation and function. These alterations can result in disease or alter economically important agricultural traits.</p>
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Research projects include characterizing the degree of horizontal gene transfer in vertebrates, model organism databases, data mining and determining the effect of disregulated retrotransposons on genome stability.</p>
Chromosomal assignment of six genes (EIF4G3, HSP90, RBBP6, IL8, TERT, and TERC) in four species of the genus Equus
No full textWe mapped six genes (EIF4G3, HSP90, RBBP6, IL8, TERT, and TERC) on the chromosomes of Equus caballus, Equus asinus, Equus grevyi, and Equus burchelli by fluorescence in situ hybridization. Our results add six type I markers to the cytogenetic map of these species and provide new information on the comparative genomics of the genus Equus.Pamela Vidale, Francesca M. Piras, Solomon G. Nergadze, Livia Bertoni, Andrea Verini-Supplizi, David Adelson, Gérard Guérin and Elena Giulott
Evidence for a retroviral insertion in TRPM1 as the cause of congenital stationary night blindness and leopard complex spotting in the horse
No full textLeopard complex spotting is a group of white spotting patterns in horses caused by an incompletely dominant gene (LP) where homozygotes (LP/LP) are also affected with congenital stationary night blindness. Previous studies implicated Transient Receptor Potential Cation Channel, Subfamily M, Member 1 (TRPM1) as the best candidate gene for both CSNB and LP. RNA-Seq data pinpointed a 1378 bp insertion in intron 1 of TRPM1 as the potential cause. This insertion, a long terminal repeat (LTR) of an endogenous retrovirus, was completely associated with LP, testing 511 horses (χ²=1022.00, p<<0.0005), and CSNB, testing 43 horses (χ2=43, p<<0.0005). The LTR was shown to disrupt TRPM1 transcription by premature poly-adenylation. Furthermore, while deleterious transposable element insertions should be quickly selected against the identification of this insertion in three ancient DNA samples suggests it has been maintained in the horse gene pool for at least 17,000 years. This study represents the first description of an LTR insertion being associated with both a pigmentation phenotype and an eye disorder.Rebecca R. Bellone … David L. Adelson, Sim Lin Lim … et al
Derivation of an endogenous small RNA from double-stranded Sox4 sense and natural antisense transcripts in the mouse brain
No full textAbstract not availableKing-Hwa Ling, Peter J. Brautigan, Sarah Moore, Rachel Fraser, Pike-See Cheah, Joy M. Raison, Milena Babic. Young Kyung Lee, Tasman Daish, Deidre M. Mattiske, Jeffrey R. Mann, David L. Adelson, Paul Q. Thomas, Christopher N. Hahn, Hamish S. Scot
Heterosis and heterosis retention for reproductive and maternal traits in Brahman - British crossbred cows
No full textReproductive, maternal, and weight traits were analyzed for Angus (A), Brahman
(B), and Hereford (H) straightbred cows; F1 and F2 BA and BH cows; and 3/8 B 5/8 A
first (Bn) and second (Bn2) generation cows in Central Texas. Heterosis was estimated
for calf crop born (CCB), calf crop weaned (CCW), and cow weight at palpation (PW)
by linear contrasts within cow breed groups. F1 BA cows expressed heterosis (P<0.01)
for CCB (0.10) and CCW (0.11), while F2 BA cows expressed negative heterosis
(P<0.10) for CCB (-0.06) and CCW (-0.07). F1 BH cows expressed heterosis (P<0.001)
for CCB (0.15) and CCW (0.16), and F2 BH cows retained F1 heterosis (P<0.001) for
CCB (0.13) and CCW (0.15). Bn2 cows expressed heterosis (P<0.01) for CCB (0.14),
but Bn cows did not express heterosis (P>0.10) for CCB or CCW. Only the F1 BA (22.9
kg) and F2 BH (42.1 kg) groups expressed heterosis (P<0.10) for PW. Bn2 cows (-65.7
kg) expressed negative heterosis (P<0.01) for PW. Heterosis for calf survival (CS), birth
weight (BW), and weaning weight (WW) was estimated by linear contrasts within calf
breed groups for B- and H-influenced calves. F1 BH (0.11) and F2 BH (0.14) calves
expressed heterosis (P0.10)
for BW, but B-sired F1 BH calves were 5.5 kg heavier (P<0.01) than H-sired F1 calves at
birth. F1 BH (22.4 kg) and F2 BH (26.2 kg) calves expressed heterosis (P<0.001) for
WW, and H-sired F1 BH calves were 20.7 kg heavier (P<0.10) than B-sired F1 calves at
weaning
Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research
No full textOver-represented GO terms of neighbor genes of 3′ end gene-proximate intergenic ncRNAs in human (A), mouse (B) and zebrafish (C).
No full text<p>The bubble color indicates the P-value (EASE score from DAVID); bubble size indicates the frequency of the GO term in the underlying GOA database. Highly similar GO terms are linked by edges in the graph. Regulatory GO terms were highlighted with cyan-like colors, and developmental-associated GO terms were highlighted with gold colors.</p
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