1,720,978 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Timolol maleate opthalmic formulations based on carrageenan-gelatin mixtures: in vitro and preliminary in vivo studies
No full textPoloxamer 407 based microspheres for atenolol transbuccal delivery: in vitro and in vivo evaluation
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Valutazione della permeazione buccale di atenololo da microsfere prodotte mediante spray congealing
No full textLa somministrazione attraverso la via buccale rappresenta un’interessante alternativa alla via orale per i farmaci che subiscono degradazione nel tratto gastro-intestinale o un elevato metabolismo di first-pass epatico. L’atenololo un beta-bloccante ampiamente impiegato nel trattamento di patologie cardiovascolari, è un farmaco di classe III secondo la classificazione BCS, cioè altamente solubile e scarsamente permeabile. Lo scopo di questa ricerca era quello di valutare l’aumento di permeazione del farmaco attraverso la mucosa buccale dai sistemi microparticellari, sia in dispersione acquosa che in compressa, in confronto con veicoli contenenti il farmaco in forma non microincapsulata.
Le microparticelle avevano come carrier bassofondente Poloxamer 407 (Lutrol F 127) (lotto 1) o miscele poloxamer 407-Gelucire 50/13 in rapporto 3:1 (lotto 2); il contenuto teorico di atenololo era del 20% (p/p) in entrambe le formulazioni. Le microparticelle avevano dimensioni comprese tra 100 e 500 micron, forma regolare e sferica e buone proprietà di mucoadesione.
Gli studi di permeazione buccale venivano eseguiti mediante celle di dissuasione di Gummer utilizzando la mucosa buccale di maiale quale substrato. I veicoli saggiati erano: soluzione acquosa di AT (SOL); dispersione acquosa contenente le microparticelle (DA-M1; DA-M2); dispersione acquosa della miscela fisica dei singoli componenti (DA-MF1; DA-MF2); compresse contenenti le microparticelle (CP-M1; CP-M2) e compresse contenenti la miscela fisica dei singoli componenti (CP-MF1; CP-MF2). Ad intervalli di tempo predeterminati, la fase ricevente veniva prelevata ed analizzata mediante HPLC per determinare la quantità di atenololo permeata. Lo studio ha dimostrato che le due dispersioni microparticellari portavano ad un aumento della permeazione transbuccale di AT rispetto sia a SOL che a DA-MF1 e DA-MF2. La quantità di AT permeata nel tempo si riduceva notevolmente quando come veicolo venivano utilizzate le CP. I parametri di permeazione mostravano inoltre che le formulazioni conteneti solo Lutrol F127 permettevano un passaggio del farmaco attraverso il substrato quantitativamente maggiore rispetto alla miscela Lutrol F127/ Gelucire 50/13
Ciprofloxacin-chondrotin sulphate suspensions for ophthalmic application. Preliminary evaluation of precorneal residence
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