509 research outputs found
Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C
No full textBACKGROUND & AIMS: Non-invasive assessment of liver fibrosis is a challenging area. Several methods have been proposed in patients with chronic hepatitis C (CHC) but their performance may be improved when they are combined as suggested by recently proposed algorithms using either transient elastography (TE) and Fibrotest (FT) (Castera) or AST-to-Platelet Ratio Index (APRI) and FT (SAFE biopsy). The aim of this prospective study was to compare the performance of these two algorithms for diagnosing significant fibrosis and cirrhosis in 302 CHC patients.
METHODS: All patients underwent TE, FT and APRI the same day as liver biopsy, taken as reference standard.
RESULTS: Significant fibrosis (Metavir F>or=2) was present in 76% of patients and cirrhosis (F4) in 25%. TE failure was observed in eight cases (2.6%). For significant fibrosis, Castera algorithm saved 23% more liver biopsies (71.9% vs. 48.3%, respectively; p<0.0001) than SAFE biopsy but its accuracy was significantly lower (87.7% vs. 97.0%, respectively; p<0.0001). Regarding cirrhosis, accuracy of Castera algorithm was significantly higher than that of SAFE biopsy (95.7% vs. 88.7%, respectively; p<0.0001). The number of saved liver biopsies did not differ between the two algorithms (78.8% vs. 74.8%; p=NS).
CONCLUSIONS: Both algorithms are effective for non-invasive staging of liver fibrosis in chronic hepatitis C. Although the number of liver biopsies avoided does not differ between algorithms for diagnosing cirrhosis, it is significantly higher with Castera algorithm than SAFE biopsy for significant fibrosis
Querens
No full textReprint of a book in Spanish, first published in 1890, in which the author Pedro Castera addresses with the idea of ''controlling the will of another human being'' through scientific and pseudoscientific theories of the 19th century
J.-L. Gazzaniga, J.-P. Ourliac, X. Larrouy-Castera, « L'eau : usages et gestion », collection Administration territoriale, 1998
No full textDrobenko Bernard. J.-L. Gazzaniga, J.-P. Ourliac, X. Larrouy-Castera, « L'eau : usages et gestion », collection Administration territoriale, 1998. In: Revue Juridique de l'Environnement, n°2, 1999. pp. 321-322
J.-L. Gazzaniga, J.-P. Ourliac, X. Larrouy-Castera, « L'eau : usages et gestion », collection Administration territoriale, 1998
No full textDrobenko Bernard. J.-L. Gazzaniga, J.-P. Ourliac, X. Larrouy-Castera, « L'eau : usages et gestion », collection Administration territoriale, 1998. In: Revue Juridique de l'Environnement, n°2, 1999. pp. 321-322
Ode sur le baptême de Son Altesse Royale, Mgr Henri de France, duc de Bordeaux (par Castera d'Artigues)
No full textAppartient à l’ensemble documentaire : LangRous1Avec mode text
Prediction of oesophageal varices in hepatic cirrhosis by simple serum non-invasive markers: Results of a multicenter, large-scale study
No full textBACKGROUND; AIMS:
Preliminary data suggest that non-invasive methods could be useful to assess presence of oesophageal varices (OV) in cirrhotic patients. We aimed to further investigate simple serum non-invasive markers for diagnosing and grading OV.
METHODS:
A retrospective set of 510 cirrhotics and a prospective set of 110 cirrhotics were enrolled consecutively in five centers. Platelets, AST-to-ALT ratio, AST-to-platelet-ratio index, Forns' index, Lok index, Fib-4, and Fibroindex were measured within 2 months from upper endoscopy, taken as a gold standard. Performance was expressed as sensitivity, specificity, positive, and negative predictive values (PPV, NPV), accuracy, and area under the curve (AUC).
RESULTS:
A combination of Lok index (cutoff=1.5) and Forns' index (cutoff=8.8) had 0.80 AUC (0.76-0.84, 95% CI), and high NPV (>90%) to exclude clinically relevant OV, defined as large OV or small OV with red signs or in Child-Pugh C cirrhosis. By applying this combination, upper endoscopy would have been avoided in 1/3 of our cirrhotics. Large OV could be excluded with 96% NPV by Lok index (cutoff=1.5). A combination of Lok index (cutoff=0.9) and Forns' index (cutoff=8.5) predicted presence of any grade OV with good performance: 0.82 AUC (0.76-0.88, 95% CI), 88% PPV.
CONCLUSIONS:
Serum non-invasive markers may be useful as a first line tool to identify cirrhotic patients in which the risk of clinically relevant OV is trivial, and to reduce the number of upper endoscopies. However, we are still far from the possibility of replacing upper endoscopy by simple serum non-invasive markers in the vast majority of patients
Prospective comparison of two algorithms combining non invasive tests for staging of liver fibrosis in chronic hepatitis C
No full textPrediction of oesophageal varices (OV) in hepatic cirrhosis by serum non-invasive markers: results of a multicenter, international study
No full textLarge-scale multicenter comparison of three algorithms combining serum non-invasive markers for liver fibrosis in chronic hepatitis C
No full textLa qualité du bois de pin maritime.
No full textCet article nous présente les principales caractéristiques de la qualité du bois de pin maritime. Bien que les études aient été réalisées sur des pins d'origine landaise, les résultats sont pour l'essentiel transposable au pin mésogéen
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