1,721,016 research outputs found
Robot-assisted radical prostatectomy in patients with a history of endoscopic treatment for benign hyperplasia of the prostate
No full textAim: The purpose of this study was to determine whether
previous prostate surgery has an adverse effect on the
perioperative, histopathological and functional outcomes of
robot-assisted radical prostatectomy (RARP). Patients and
Methods: We retrospectively identified 42 patients (Group 1)
who had a history of endoscopic prostate surgery for the
treatment of benign prostate hyperplasia (BPH). We performed
one-to-one matching based upon ten variables (age, BMI,
PSA, SHIM, AUA-SS, c stage, biopsy Gleason score, median
lobe presence, pathological stage and the extent of nervesparing)
using a propensity score matching algorithm to
generate a control group (Group 2). The perioperative,
histopathological and functional outcomes were compared
between these groups. All the patients were evaluated for
continence outcomes, while only those patients who had a
preoperative SHIM score of 17 and had a nerve-sparing
surgery (unilateral, bilateral or partial) were examined for
potency outcomes. Results: The patient demographics after
matching are listed in Table I. The perioperative
histopathological and functional outcomes were evaluated.
There was no statistically significant difference at any point in
time for either continence or potency outcomes Conclusion:
RARP is a safe and effective procedure in patients who have
a history of endoscopic prostate surgery. Although the OR
time is higher in these patients, the PSM rates, complications,
histopathological and functional outcomes are comparable to
those of patients who have no prior prostate surgery
Case report : cystoscopic use of cyanoacrylate glue for bleeding during transurethral resection of bladder tumors
No full textAn 81-year-old woman with a history of nephroureterectomy and bladder cuff excision for grade 3 stage pT3N0M0 transitional-cell neoplasia presented with three bladder neoplasms. She also had symptomatic varicose veins in the lower extremities and received low-molecular-weight heparin. During transurethral resection of the tumors, deep ablation of the base of one lesion resulted in significant arterial bleeding that could not be controlled with normal endoscopic techniques. On the basis of previous positive experience, we endoscopicaly injected 3 mL of cyanoacrylate glue (Glubran 2) deeply (5 mm) into the tissue surrounding the bleeding site, making four injections with a device used for collagen injections. The area was irrigated with mannitol and sorbitol, and within a few seconds, there was complete remission of bleeding. We waited a further 90 seconds with the bladder distended to allow the substance to lose its adhesive properties so as to avoid having the bladder walls stick together. The catheter was removed on the third day, with resumption of micturition and clear urine. This appears to be the first case of cystoscopic use of cyanoacrylate glue to control bleeding
Epidemiology of renal colic in a district general hospital
No full textBACKGROUND/AIMS: To assess the incidence of renal colic and the results of emergency management. METHODS: During a 12 month period data of patients with symptoms of renal colic were collected. RESULTS: A total of 495 visits were registered. The M/F was 2.19. Mean age was higher in males (45.5+/-13.0 vs 42.5+/-15.5 years, P=0.025). Three patients were hospitalised for immediate urinary diversion due to anuria or sepsis. Fifty-three patients recovered without performing any pharmacological treatment. Analgesic treatment (mainly NSAID) was offered to 439 patients. After a 6 hour period 36 patients were admitted to the hospital owing to persistent pain. Pain was reduced in 403 patients (91.8%) who were offered outpatient renal ultrasound within 48 hours. Twenty-five patients (6.2%) required deferred hospitalisation. Follow up with renal ultrasound was obtained in 213. CONCLUSION: Renal colics accounted for 0.9% of ambulatory care visits to our emergency departments with an annual rate of 0.158 visits per 100 in the general population. NSAIDs were efficacious in the management of colic. Diagnostic work up was able to demonstrate the presence of a stone in 56% of the subjects presenting with renal colic whereas alternative diagnoses were demonstrated in 12%
L'iperespressione di cerbB2 nel carcinoma vescicale
No full textSCOPO DEL LAVORO:
Valutare la relazione tra l'espressione dell'oncogene cerbB2 e il grado dei tumori a cellule transizionali
della vescica, attraverso due metodiche: analisi immunoistochimica ed analisi quantitativa basata sulla
metodologia Taqman (RealTime RTPCR).
MATERIALI E METODI:
Il materiale utilizzato è stato ottenuto da campioni operatori da un totale di 111 pazienti (55 cistectomie
e 56 resezioni endoscopiche transuretrali). Per quanto riguarda il grading istologico (WHO/ISUP
2002), 30 casi (27%) erano carcinomi uroteliali a basso grado, 81 (73%) erano ad alto grado di malignità.
Per quanto riguarda lo stadio (TNM 2006): 32 casi erano Ta, 18 casi T1, 16 casi T2, 31 casi T3, 14
casi T4. L'analisi immunoistochimica è stata effettuata su sezioni in paraffina utilizzando l'anticorpo
monoclinale HER2/neu (DAKO). L'analisi molecolare è stata condotta su 15 prelievi di mucosa vescicale
neoplastica e 2 di mucosa sana. La metodica utilizzata è stata la RealTime RTPCR.
RISULTATI:
Per l'analisi immunoistochimica: 27 carcinomi (24%) hanno dimostrato positività immunoistochimica
per HER2/neu. In base al grado sec. WHO/ISUP 2002, esse si raggruppavano in 2(7%) carcinomi a basso
grado e 25 (93%) ad alto grado. Per quanto riguarda lo stadio, le neoplasie risultavano così distribuite:
4 Ta, 9 T1, 3 T2, 10 T3, 1 T4. A fini statistici le neoplasie sono state suddivise in due gruppi: superficiali
(Ta) versus infiltranti (T1T4); l'analisi condotta tramite il TStudent ha evidenziato una correlazione statisticamente
significativa tra iperespressione e stadi più avanzati (p=0.01). Per l'analisi molecolare: la
RTPCR ha mostrato in tutti i casi livelli evidenziabili di HER2/neu mRNA, sia su prelievi di mucosa neoplastica
che normale. Nei 3 prelievi di mucosa normale, i livelli di mRNA riscontrati sono più bassi rispetto
alla controparte neoplastica. Tra i prelievi neoplastici, nel 60% dei casi erano dimostrabili livelli elevati
di HER2/neu mRNA.
DISCUSSIONE:
La corretta valutazione dell'iperespressione di cerbB2 è di estremo interesse in vista di un utilizzo di
anticorpi monoclonali (Herceptin, Trastuzumab) per i carcinomi vescicali di stadio avanzato o per quelli
che non rispondono alla chemioterapia convenzionale.
MESSAGGIO CONCLUSIVO:
L'iperespressione di cerbB2 è risultata direttamente proporzionale al grado ed allo stadio della neoplasia.
Con la RTPCR è stato possibile evidenziare cerbB2 mRNA in tutti i casi, con valori elevati di mRNA
nel 60% dei tumori analizzati. I risultati ottenuti attraverso le due metodiche sono significativamente
correlati, benché le analisi molecolari RTPCR mostrino una maggiore sensibilità (possibilità di svelare i
falsi negativi). Ulteriori studi con followup più lungo ed un maggior numero di pazienti possono meglio
stabilire il ruolo dell'espressione di cerbB2 come fattore prognostico per il tumore della vescica
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Tolterodine improves quality of life in patients with an overactive bladder, with or without urinary incontince : a prospective multicenter study
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