2,599 research outputs found
Differential cross-section for 6He+p and 6He+d elastic scattering at 26 MeV/n
No full textDataset contains experimentally measured differential cross-sections for elastic scattering of 6He+p and 6He+d at 26 MeV/n energy. The measurement was performed in 2018 in Flerov Laboratory of Nuclear Reactions, Joint Institute for Nuclear Research, Dubna, Russia. The details of the experimental setup and data analysis are described in https://link.aps.org/doi/10.1103/PhysRevC.111.054616</p
Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands
No full textCopyright © 2008 Elsevier B.V. All rights reserved.Background and aimsZinc is abundant in pancreas, being required by endocrine islet cells for hormone secretion and by exocrine acinar cells as pancreatic juice component. ZnT8 is a member of the SLC30A family of zinc transporters whose overexpression in cultured pancreatic beta cells leads to increased insulin secretion in response to glucose, suggesting a possible role in regulating glycemia. ZnT8 was therefore proposed as a therapeutic target for diabetes, and recent genome-wide association studies identified polymorphisms in the ZNT8 gene conferring increased type 2 diabetes risk.Methods and resultsAs limited information was available on the biochemical properties of ZnT8 and on its endogenous expression, we have raised a specific polyclonal antibody and immunostained protein extracts, cell lines and tissue sections. We show that ZnT8 forms a very stable dimer that requires biological membranes to properly assemble. We demonstrate localization of murine ZnT8 to the secretory granules in pancreatic beta and alpha islet cells. Moreover, we show that ZnT8 is also expressed in other secretory cell types, namely the cubical epithelium that lines thyroid follicles and the cortex of the adrenal gland, suggesting a more widespread role in endocrine secretion.ConclusionWe provide novel insights into the features of the ZnT8 transporter, of special relevance in light of its proposed role as therapeutical target for diabetes treatment.C. Murgia, C. Devirgiliis, E. Mancini, G. Donadel, P. Zalewski and G. Perozz
Der Umgang mit dem kulturellen Erbe in Deutschland und Polen im 20. Jahrhundert
No full text9. Tagung des Arbeitskreises deutscher und polnischer Kunsthistoriker, Leipzig 25.-29. September 2002. von Katja Bernhardt und Przemislaw P. Zalewski Rezension in polnischer Sprache
Criminal Biology: On the Proper Place of Science in Explaining the Origin of Crime
No full textThe aim of the paper is to investigate how the influence of biology on human behaviour can be explained in terms of criminal law today. Wojciech Zalewski begins the article by introducing and explaining the grounds for criticism of criminal biology at the beginning of the 20th century. The paper then goes on to outline the criticism of criminal anthropology and the biological approach in Poland. To this end, the author extensively discusses the research of Prof. Adam S. Ettinger and other prominent researchers who rejected entirely endogenous sources of crime. The author also draws our attention to the interest in criminal biology by the leaders of the National Socialist party in Germany in the first half of the 20th century. The paper also discusses the issue of eugenics and the use of its principles worldwide. Moreover, the author discusses the contemporary state of the criminological debate, suggesting that the 20th century should be considered as dominated by the sociological approach in criminology and by a failure of criminological views to influence politicians and penal legislation. In conclusion, Zalewski highlights the contribution of the pioneers of the anthropological approach in criminology and points out that research into the biological causes of crime should be handled with scientific objectivity and, in particular, the influence of the social environment should be taken into account.Celem opracowania jest znalezienie odpowiedzi na pytanie, jak można współcześnie w kategoriach prawnokarnych wyjaśnić wpływ biologii na zachowanie człowieka. Autor tekstu rozpoczyna artykuł od przybliżenia i wyjaśnienia odbiorcom podstaw krytyki biologii kryminalnej na początku XX wieku. Następnie w publikacji prezentowana jest krytyka antropologii kryminalnej i biologicznego podejścia na gruncie polskim. W tym celu autor artykułu szeroko omawia badania profesora Adam S. Ettingera i innych wybitnych badaczy, którzy odrzucali całkowicie endogenne przyczyny przestępczości. Autor tekstu zwraca również uwagę odbiorców na zainteresowanie biologią kryminalną przez przywódców partii narodowosocjalistycznej w Niemczech w I połowie XX wieku. W opracowaniu omówiona została również problematyka eugeniki i wykorzystania jej założeń na świecie. Autor artykuł omawia także współczesny stan debaty kryminologicznej sugerując, że wiek XX należy uznać za zdominowany przez podejście socjologiczne w kryminologii i porażkę wpływu kryminologicznych opinii na polityków i ustawodawstwo karne. W podsumowaniu W. Zalewski uwydatnia wkład pionierów podejścia antropologicznego w kryminologii i podkreśla, że do badań nad biologicznymi przyczynami przestępczości należy podchodzić z naukowym obiektywizmem a zwłaszcza należy zwracać uwagę na wpływ otoczenia społecznego.
The aim of the paper is to investigate how the influence of biology on human behaviour can be explained in terms of criminal law today. Wojciech Zalewski begins the article by introducing and explaining the grounds for criticism of criminal biology at the beginning of the 20th century. The paper then goes on to outline the criticism of criminal anthropology and the biological approach in Poland. To this end, the author extensively discusses the research of Prof. Adam S. Ettinger and other prominent researchers who rejected entirely endogenous sources of crime. The author also draws our attention to the interest in criminal biology by the leaders of the National Socialist party in Germany in the first half of the 20th century. The paper also discusses the issue of eugenics and the use of its principles worldwide. Moreover, the author discusses the contemporary state of the criminological debate, suggesting that the 20th century should be considered as dominated by the sociological approach in criminology and by a failure of criminological views to influence politicians and penal legislation. In conclusion, Zalewski highlights the contribution of the pioneers of the anthropological approach in criminology and points out that research into the biological causes of crime should be handled with scientific objectivity and, in particular, the influence of the social environment should be taken into account
Proposed diagnostic criteria for spinal cord infarction (by Zalewski NL et al., 2019).
No full textProposed diagnostic criteria for spinal cord infarction (by Zalewski NL et al., 2019).</p
Unknown Medieval Fragments in German from the Ludwik Zalewski Collection at the Polish National Library, Warsaw
No full textAmong others, the Polish National Library possess a collection (MS 8098 IV) encompassing parchment fragments extracted from bookbindings, which contain German texts. This collection was acquired from the family of the deceased bibliophile from Lublin, Father Ludwik Zalewski. The collection consists of eleven parchment leaves, six of which form three bifolia, the other five being small fragments. The collection is known to historians, chiefly due to two of the bifolia, which contain fragments of an Old Saxon translation of the Psalms (Altsächsiche Psalmen). The rest of the fragments, dated chiefly by the author to the fourteenth century, are also of interest. J. Kaliszuk identifies them as belonging to: Der Welsche Gast by Thomasin von Zerklaere, the Christherre-Chronik and the Livländische Reimchronik. The author also demonstrates that this collection was put together by L. Zalewski, hence there is no possibility of tracing the provenance of individual fragments. The article is supplemented by two appendices, the first with codicological descriptions of the complete collection, and the second containing an edition of the letter from Stanisław Tomkowicz, an art historian from Cracow, to Ludwik Zalewski, written in 1916, concerning the fragments in question
Hypoxia-induced reduction in no signalling as well as increased oxidative stress and inflammation are associated with dysregulated zinc homeostasis in endothelial cells
No full textTran, H., Maiolo, S, Abdo, A, Jacobczak, R, Beltrame, J, Reynolds, P, Zalewski, P, Hodge,
Dysregulation of zinc and s1p signalling in pulmonary artery hypotension is alleviated by bmpr2 upregulation
No full textOral Abstracts TO 051Tran H, Maiolo S, Harper R, Liu H Zalewski P, Reynolds P, Hodge
L'impact des politiques de conservation sur les populations rurales de l'Afrique de l’ouest
No full textZalewski Sally. L'impact des politiques de conservation sur les populations rurales de l'Afrique de l’ouest . In: Revue d'Écologie (La Terre et La Vie), tome 59, n°1-2, 2004. p. 392
Extreme Value Theory in Application to Freight Delivery Delays
No full textRaw data presents a set of deliveries. Delays in deliveries in the supply chain. Data related to the implementation of deliveries by road transport.</p
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