298 research outputs found

    Bridge of Spaces: East by Rear East

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    Alterations in structural and functional responses of bacterial community in response to different levels of compost application in long term fertilized paddy ecosystems

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    In this study, we used pyro-sequencing tags between V1-V3 regions of the 16S rRNA gene to analyse and compare the effect of long term application of different compost levels on the composition of paddy soil bacterial communities. The treatments were (i) inorganic nitrogen (N), phosphorus (P) and potassium (K) fertilizers (NPK) (ii) NPK and organic compost (C) (NPKC750) (iii) NPKC1500 (iv) NPKC2250 (v) NPKC3000. Inorganic chemical fertilizer was applied as N–P2O5–K2O at a rate of 75-75-75 kg ha-1 from 1954-1970, 100-75-75 kg ha-1 from 1971-1978, 150-86-86 kg ha-1 from 1978-1985 and 110-70-80 kg ha-1 from 1986 onwards. Organic compost was prepared by fermenting rice straws for 5 months and then applied at 7.5, 15.0, 22.5 and 30.0 Mg ha-1 in the NPKC750, NPKC1500, NPKC2250 and NPKC3000 soils, respectively

    Resilience: an all-encompassing solution to global problems? A biopolitical analysis of resilience in the policies of EC, FEMA, UNDP, USAID, WB, and WEF

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    This thesis examines the use of resilience in international policy-making. A concept that originally meant an ability of ecosystems to absorb disturbance has not only been welcomed in many disciplines outside ecology, but lately become popular in the policies of international organisations that claim resilience as a solution to various ‘global problems’ such as climate change, underdevelopment, or economic crises. The study contributes to the ongoing critical discussion on the governance effects of resilience. Here, the Foucauldian theory of biopolitics and the concept of governmentality are useful. Resilience now addresses human systems and communities with concepts from natural sciences, thus making it a biopolitical phenomenon. Specifically, the thesis asks how mainstreaming resilience affects the pursuit of agendas in six organisations: European Commission, Federal Emergency Management Agency, United Nations Development Programme, United States Agency for International Development, World Bank, and World Economic Forum. Using Foucauldian discourse analysis, the study is thematically divided into adaptive, entrepreneurial and governing aspects of resilience. Each part explicates how truth, power and subjectivity are constructed in the discourse. The analysis shows that contrary to the policy claims, resilience does not function as a solution but is constitutive of the problems it attempts to solve. The current policy discourse confirms pre-existing practices and power relations, and further problematizes issues on the agendas. The thesis confirms that the policies are trapped in a neoliberal biopolitics that has problematic implications for human subjectivity and political agency. It further concludes that if resilience is to have any practical relevance and positive effects, the policy discourse has to be changed, for which current critical accounts do not offer a plausible direction. Therefore, a distinction between resilience as a policy tool and social resilience is needed, whereby the use of resilience as a policy solution is reduced to disaster risk reduction and similar technical functions, and social resilience is recognised as a communal capacity that cannot be subject to policy regulation

    The Synaptonuclear Messenger RNF10 Acts as an Architect of Neuronal Morphology

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    The Ring Finger Protein 10 [RNF10] is a novel synapse-to-nucleus signaling protein that specifically links activation of synaptic NMDA receptors to modulation of gene expression. RNF10 dissociation from the GluN2A subunit of the NMDA receptor represents the first step of its synaptonuclear transport and it is followed by an importin-dependent translocation into the nucleus. Here, we have identified protein kinase C [PKC]-dependent phosphorylation of RNF10 Ser31 as a key step for RNF10 detachment from NMDA receptor and its subsequent trafficking to the nucleus. We show that pSer31-RNF10 plays a role both in synaptonuclear signaling and in neuronal morphology. In particular, the prevention of Ser31 RNF10 phosphorylation induces a decrease in spine density, neuronal branching, and CREB signaling, while opposite effects are obtained by mimicking a stable RNF10 phosphorylation at Ser31. Overall, these results add novel information about the functional and structural role of synaptonuclear protein messengers in shaping dendritic architecture in hippocampal neurons

    Stoma reversals following open abdomen management: A retrospective study from Eastern India

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    Background: Stoma creation during open abdomen (OA) management is often necessary to reduce sepsis and protect anastomoses. However, there is no evidence on reversal timing and outcomes in this high-risk group. Aims and Objectives: To evaluate stoma-related complications, reversal timing, operative outcomes, and post-reversal morbidity in patients who underwent stoma formation during OA management. Materials and Methods: We conducted a retrospective analysis of 32 patients who underwent stoma reversal following OA management between May 2022 and April 2025, with follow-up until June 2025. Patient demographics, nutritional parameters, comorbidities, stoma type, interval to reversal, and intra- and post-operative outcomes were analysed. Statistical comparisons were performed using the Mann–Whitney U and Fisher’s exact tests with Bonferroni correction by the Statistical Package for Social Sciences version 26 (IBM, NY, USA). Results: Of 32 patients, 6 had jejunostomies, 17 had ileostomies, and 9 had colostomies. Colostomy patients were older (mean 59.9 years) than ileostomy (55.8 years) and jejunostomy (50.8 years). Jejunostomy patients had poorer nutritional parameters. Median wait times were significantly shorter for jejunostomy compared with ileostomy (P=0.0142) and colostomy (P=0.0015). Ileostomy reversals had the shortest operative times (85 min vs. 117.5 min for jejunostomy, P=0.0117; 150 min for colostomy, P=0.0006). Stoma-related complications were most frequent in jejunostomy (83%), compared with ileostomy (29%) and colostomy (22%) (P=0.024). Post-reversal complications occurred in 66.7% of jejunostomy, 41.2% of ileostomy, and 44.4% of colostomy patients, respectively. One mortality occurred in the jejunostomy group due to hypokalemia. Conclusion: Jejunostomy patients experienced the highest morbidity requiring earlier reversal. Ileostomy reversals had shorter operative times and lower complication rates. Colostomies had the longest wait time and demonstrated broader post-operative morbidity. Stoma reversal following OA management requires balancing early closure to prevent ongoing stoma-related morbidity against delayed reversal to minimize risks from adhesions and sepsis. Larger prospective studies are required to optimize reversal timing and improve outcomes

    Governmentalizing NRI Philanthropy in Andhra Pradesh: A Transregional Approach to India’s Development

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    This chapter looks at the idea of governmentalization of NRI philanthropy in the state of Andhra Pradesh. In a detailed analysis, the author shows how the dominant community of the Kammas in the coastal Andhra region, having historically benefitted from being part of the anti-Brahmin movement, consolidated their identity as the foremost landowners with a concerted effort towards higher education and already established networks enabling them to pursue careers in the USA. This, and a belief in giving back to the village and caste that has enabled their migration and hence success in life, has encouraged philanthropy in the region, in terms of NRI contribution to the NRI cell of Zilla Parishad and the Janmabhoomi project of the then TDP government. This is crucial because, with the term ‘governmentalization ’, she shows how caste interests influence government policy and shape the direction which philanthropy will take, who will be the recipient of the philanthropic measures, how will the philanthropic projects be spatially located and how the existing structures of hegemony will continue in this curious coming together of public and private capital
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