148 research outputs found
Santiago Díaz Lage, Escritores y lectores de un día. Literaturas periódicas en la España del siglo XIX
No full textBook review: Santiago Díaz Lage, Escritores y lectores de un día. Literaturas periódicas en la España del siglo XIX. Zaragoza, PUZ, 2021. 451 p. ISBN: 978-84-1340-162-1.Reseña de: Santiago Díaz Lage, Escritores y lectores de un día. Literaturas periódicas en la España del siglo XIX. Zaragoza, PUZ, 2021. 451 p. ISBN: 978-84-1340-162-1
Pragmalingüística de la argumentación: de la filosofía del lenguaje ordinario a la lógica informal
No full textLa cuestión que vertebra este trabajo es la de las relaciones que guarda la Lógica Informal (término con el que me refiero a los estudios de Teoría de la Argumentación que se enclavan dentro del área filosófica) con la Filosofía del Lenguaje Ordinario. La idea principal es que la Lógica Informal debe leerse como como la extensión natural de los trabajos de Austin y Wittgenstein en torno al lenguaje a los temas de la inferencia y la argumentación.
Para ello se utiliza un argumento «analógico»: la filosofía del lenguaje ordinrio es a la filosofía analítica clásica como la lógica informal es a la lógica formal clásica. Se comparan pues las diferencias entre filosofía del lenguaje ordinario y la filosofía analítica clásica, y se descubre que son exactamente con las diferencias entre lógica informal y lógica formal. Se propone, además, una explicación simple de la coincidencia, que no es otra que la aproximación de cor te pragmático característica de las dos disciplinas más jóvenes. De este resultado obtengo dos conclusiones. En primer lugar, se acabará con la identificación de conceptos como «lógico », «demostración», «deducción», «válido», etc., con conceptos de la lógica formal. El problema de dar por buena esta identificación es que facilita la que se confunda la informalidad de la filosofía del lenguaje ordinario con irracionalidad. En segundo lugar, la discusión debe mostrar que la lógica informal no renuncia a toda ambición normativa, como pueda parecerlo, de nuevo, por el mero hecho de ser informal y de estar centrada únicamente en una labor descriptiva. Pero esta normatividad no emana directamente de los resultados de los lógicos informales, sino que exige el diálogo y el intercambio argumentativo con los propios agentes argumentativos, quienes son, en última instancia, los que detentan la última palabra.Ministerio de Ciencia e Innovación y Universidades (España)Depto. de Lógica y Filosofía TeóricaFac. de FilosofíaTRUEpu
Conglomerantes puzolánicos. Propiedades y aplicaciones
No full textThis paper seeks to emphasize the importance of making use of puzzolanic type cements to improve the durability of many kinds of structures.
Only in cases when it is necessary to use a cement which must become very strong within a very short time, such as P-450, will it not be possible to substitute a Portland by a puzzolanic cement. But on the other hand, if we can substitute a P-250 or a P-350 by a PUZ-250 or by a PUZ-350, respectively, we shall have succeeded in obtaining the equivalent of an improved Portland cement, from whose hydrated content the quench lime has disappeared. This lime is a harmful material, which portland cement always produces when it hardens.
P-450 has not an equivalent PUZ cement, but in the range where there are suitable equivalents, we should attempt to substitute Portland by the corresponding puzzolanic cements. In this way we shall help to meet the true requirements of high quality in this field.En el presente trabajo se ha tratado de poner de manifiesto la importancia que, para mejorar la durabilidad de gran número de obras, tiene la adopción de un conglomerante de tipo puzolánico.
Tan sólo cuando se requiera el empleo de un conglomerante al que haya que solicitar alta resistencia mecánica a muy corto plazo, es decir, cuando nos veamos forzados a emplear un P-450, no nos será posible sustituir el portland por un cemento puzolánico. Sí podemos, en cambio, reemplazar a un P-250 o a un P-350 por im PUZ-250 o un PUZ-350, respectivamente. Con tal elección habremos conseguido el equivalente a un portland mejorado, de cuyo seno hidratado ha desaparecido la cal apagada, sustancia nociva que el portland genera siempre al endurecer.
Y así como el P-450 no tiene un PUZ equiparable, hemos de procurar no invadir, con los cementos portland, el amplio campo que corresponde a los puzolánicos. De esta forma atenderemos adecuadamente al concepto real de calidad
Elevated factor VIII level and stroke in patients without traditional risk factors associated with cardiovascular diseases
No full textAnetta Lasek-Bal, Przemyslaw Puz, Zofia KazibutowskaStroke Unit, Department of Neurology, Medical University of Silesia, Professor Leszek Giec Upper Silesian Medical Centre, Katowice, PolandIntroduction: Hemostasis is affected by interactions between physiological processes, including those connected with the coagulation system, whose essence is converting fibrinogen into fibrin. The role of factor VIII (FVIII) consists in activating factor X, which directly participates in the generation of thrombin, which is able to produce stable fibrin, which in turn forms blood clots. There are divergent opinions regarding the significance of high levels of FVIII in stroke pathogenesis.Aim: The aim of our study was to evaluate FVIII activity in individuals with cryptogenic stroke in order to determine a potential relationship between it and cerebral ischemia.Material and methods: Nine patients suffering with stroke were used in this study: six women and three men aged 49–63 years. In all of the patients, the presence of known and potential risk factors for stroke had been excluded during previous diagnostic procedures. These patients accounted for 1.2% of the 719 people who suffered a stroke and were hospitalized in 2011 at the Stroke Unit. FVIII activity was examined in each of the nine qualified subjects within 1–2 months of the occurrence of stroke (the first test) and repeated (the second test) in five patients with abnormal results obtained from the first examination.Results: Increased activity of FVIII was found in 5 out of 9 patients. In patients with abnormal results, elevated FVIII was found in follow-up examinations in the 8th–10th month following stroke. Hemodynamic abnormalities in carotid or cerebral artery (presence of thrombus) were found in 3 of the 5 patients with increased FVIII levels. In the first 24 hours following stroke the neurological state of patients with abnormal FVIII was worse than individuals with normal FVIII activity. The patients with abnormal FVIII levels were found to be more disabled in the examination of self-dependence on the 90th day after stroke.Conclusion: When searching for the causes of stroke, it is worth examining the coagulation system, including FVIII concentration, the abnormality of which may play a significant part in brain ischemia. More research is needed to determine the relationship between abnormal FVIII activity and stroke.Keywords: factor VIII, cryptogenic stroke, hemostasis, risk facto
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Jigsaw Percolation on Erdos-Renyi Random Graphs
No full textWe extend the jigsaw percolation model to analyze graphs where both underlying
people and puzzle graphs are Erd\H{o}s-R\'enyi random graphs. Let and
denote the probability that an edge exists in the respective people and
puzzle graphs and define , the effective
probability. We show for constants c_1>1 and c_2> \pi^2/6 and the critical effective probability
, satisfies $c_3 < p^c_{\text{eff}}n\log n < c_2.
Evaluation of drug-related problems identified during medicines use review service in Slovenia
No full textUvod: Pri predpisovanju, izdajanju in uporabi zdravil nastopajo različni dejavniki tveganja, ki lahko privedejo do težav, povezanih z zdravili (DRP) in posledično predstavljajo pacientom resne zdravstvene težave in zaplete. Storitev pregled uporabe zdravil (PUZ) predstavlja orodje za prepoznavo in razreševanje DRP.
Namen: Namen magistrske naloge je bil ovrednotiti DRP pri izvajanju PUZ v Sloveniji.
Metode: Podatke smo pridobili v okviru randomizirane kontrolirane klinične raziskave Ovrednotenje koristi storitve pregled uporabe zdravil, v kateri je bil pacientom v testni skupini izveden PUZ skladno z izvajanjem storitve v praksi. Podatke smo pridobili iz izpolnjenih delovnih listov izvajalcev PUZ in pogovora s pacienti. Izvedli smo opisno analizo DRP na nivoju pacienta in na nivoju posameznih DRP po konceptu »prej-potem«. V programu IBM SPSS smo z uporabo binomskega testa ovrednotili tudi vpliv PUZ na reševanje DRP.
Rezultati: V testno skupino je bilo vključenih 77 pacientov s povprečno starostjo 68,7 let, 7,2 zdravili za redno uporabo in 2,2 zdravili po potrebi. Razlog za PUZ jim je v 56 % predstavljala polifarmakoterapija. Petdeset pacientov je imelo vsaj eno dejansko DRP, 27 pacientov pa zgolj potencialne težave. Med 221 identificiranimi DRP je bilo 90 dejanskih in sicer 60 % neželenih dogodkov (pri 39 pacientih), 18,9 % težav povezanih z učinkovitostjo zdravljenja (pri 16 pacientih), 12,2 % težav povezanih s stroški zdravljenja (pri 9 pacientih) in 8,9 % drugih težav (pri 7 pacientih). Pri dejanskih DRP smo med dejavniki tveganja klasificirali največ drugih vzrokov (pri 33 pacientih), samostojnih intervencij (pri 39 pacientih) in v celoti razrešenih težav (pri 21 pacientih). Zdravila za bolezni srca in ožilja so najpogosteje povzročala dejanske DRP (pri 26 pacientih). PUZ je značilno zmanjšal delež pacientov z vsaj 1 dejanskim DRP (p<0,001), delež vseh dejanskih DRP (p=0,001) in stopnjo ogroženosti z dejanskimi DRP (p<0,001).
Zaključek: PUZ omogoča dobro prepoznavo dejanskih DRP in kaže velik potencial za njihovo razreševanje.Introduction: When prescribing, dispensing and using drugs, various risk factors occur, which can lead to drug-related problems (DRP) and consequently present serious health problems and complications to patients. The Medicines Use Review service (MUR) is a tool to identify and resolve DRP.
Aim: The aim of the master\u27s thesis was to evaluate the DRP in the implementation of the MUR in Slovenia.
Methods: The data were obtained as part of a randomized controlled clinical trial Evaluation of the benefits of the Medicines Use Review service, in which patients in the test group were performed MUR in accordance with the implementation of the service in practice. Data were obtained from completed worksheets of MUR providers and interviews with patients. We performed a descriptive analysis of DRP at the patient level and at the level of individual DRP according to the “before-after” concept. In the IBM SPSS program, we also evaluated the impact of MUR on DRP resolution using the binomial test.
Results: The test group included 77 patients with a mean age of 68,7 years, 7,2 drugs for regular use, and 2,2 drugs as needed. The reason for MUR was polypharmacotherapy in 56% of them. Fifty patients had at least 1 manifested DRP, and 27 patients had only potential problems. Among the 221 identified DRP, 90 were manifested, namely 60% of adverse events (in 39 patients), 18.9% of treatment-related problems (in 16 patients), 12.2% of treatment-related problems (in 9 patients), and 8.9% of other problems (in 7 patients). In manifested DRP, the risk factors were classified as most other causes (in 33 patients), stand-alone interventions (in 39 patients) and fully resolved problems (in 21 patients). Cardiovascular drugs most commonly caused manifested DRP (in 26 patients). MUR significantly reduced the proportion of patients with at least 1 manifested DRP (p <0.001), the proportion of all manifested DRP (p = 0.001) and the level of risk with manifested DRP (p <0.001).
Conclusion: MUR enables good identification of manifested DRP and shows great potential for their resolutio
Componenes químicos de sebastiania schottiana muell: Arg., hipoteses sobre a correlação entre estrutura a atividade farmacológica
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Curso de Pós-Graduação em Físico-Químic
Kara śmierci jako aktualny dylemat w opinii mieszkańców Włocławka i okolic
No full textPrzedmiotem artykułu jest stosunek mieszkańców Włocławka i okolic do problemu zasadności kary śmierci. Autorka odwołuje się do badań socjologów, filozofów oraz teologów i drobiazgowo rekonstruuje sam fenomen kary głównej. Omawia pokrótce jego historię, genezę, aspekty filozoficzne i religijne. Następnie ukazuje – na przykładzie samodzielnie przeprowadzonych badań (ankieta) – stosunek społeczeństwa Włocławka i okolic do problemu. Jednocześnie autorka zastanawia się, jakie czynniki mają zasadniczy wpływ na kształtowanie się poglądów człowieka dotyczących tej kwestii.The subject of the article is an attitude of Włocławek society towards the death penalty issue. The author refers to sociological, philosophical and theological researches and reconstructs precisely the phenomenon of the capital punishment. She analyses its history, genesis, as well as philosophical and religious aspects. Furthermore she shows – using an example of her own research (questionnaire) – an attitude of Włocławek community towards the problem. At the same time the author figures out which conditions influence on opinions in this particular matter
Zofia Romanowiczowa. The outline of output and critical reception
No full textW artykule koncentruję się na przedstawieniu zarysu twórczości prozatorskiej Zofii Romanowiczowej oraz jej recepcji. Każdej z jedenastu opublikowanych powieści pisarki poświęcam fragment artykułu, uwypuklając ich stylistyczne podobieństwa oraz podkreślając charakterystyczną dla całej twórczości Romanowiczowej tematykę i problematykę. Część poświęcona recepcji ma z kolei stać się punktem wyjścia do rozważań o kanonie literatury polskiej XX wieku.The author of the article focuses on an overall picture of Zofia Romanowiczowa’s prose works and their critical reception. For each of eleven published novels of the author there was devoted a distinct part of the text, emphasizing at the same time the similarities in style and subjects so characteristic in all of writer’s work. In turn the part devoted to the critical reception is supposed to be the starting point for a reflection about the canon of twentieth century Polish literature
Safety and efficacy of fingolimod and natalizumab in multiple sclerosis after the failure of first-line therapy: Single center experience based on forty-four patients
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