213 research outputs found
Influence of early life events on immune reactivity in adult mice.
No full textThe effects of postnatal manipulations on different immune parameters were investigated in adult female mice. Postnatal stress consisted of a 15-min daily exposure to clean bedding (temperature maintained at 35 degrees C) for the first 2 weeks of life in the absence of the mother but in the presence of littermates. Controls were unhandled until weaning. At 60 days of age, female mice stressed during postnatal development showed enhanced immune reactivity as assessed by NK-cell activity and T-cell mitogenesis in comparison with unhandled mice. By contrast, B-lymphocyte proliferation induced by lipopolysaccharide (LPS) was not affected by alterations of postnatal environment. Furthermore, the association between immune reactivity and behavioral lateralization observed in adult mice was not altered by postnatal stress
PAW PREFERENCE AND BRAIN DOPAMINE ASYMMETRIES
No full textThe hemispheric content of dopamine and its metabolites in the frontal cortex, caudatus putamen and nucleus accumbens septi was evaluated in relation to behavioral lateralization assessed by paw preference. Three groups of C3H/He mice were selected on the basis of their performance in the paw preference test (left-handed, ambidextrous and right-handed) and levels of dopamine and its metabolites were measured in the two hemispheres of each group. Mice showed significant differences in hemispheric content of dopamine and 3-4 dihydroxyphenylacetic acid in the nucleus accumbens septi depending on the behavioral lateralization as expressed by paw preference. The hemispheric dominance (right hemisphere/right hemisphere + left hemisphere content of dopamine and metabolites x 100) was also calculated for each mouse. Significant differences in hemispheric dominance for dopamine, 3-4 dihydroxyphenylacetic acid and 3-methoxytyramine in the nucleus accumbens were found between right-handed and left-handed mice. This dominance was ipsilateral to the preferred paw: % right hemisphere/total content of dopamine and its metabolites were lowest in left-handed, highest in right-handed and intermediate in ambidextrous mice. Finally, individual % right hemisphere/total content for dopamine, 3-4 dihydroxyphenylacetic acid and 3-methoxytyramine in the nucleus accumbens positively correlated with individual paw preference scores. The analysis of the other brain areas did not reveal any significant effect. These results suggest a strong relationship between mesoaccumbens dopamine asymmetries and both the direction and the intensity of behavioral lateralization as expressed by paw preference in mice
Influence of brain and behavioral lateralization in brain. Monoaminergic, neuroendocrine, and immune stress responses.
No full textIntegrazione di impianti merci, rete e modelli di ottimizzazione per l’esercizio in tempo reale degli impianti // Integrating yards, network and optimisation models towards real-time rail freight yard operations
No full textThis paper describes the state of advancement achieved in the OptiYard research project in the use of optimisation algorithms in interaction with microsimulation of the rail-yard and surrounding network towards realtime yard management and communication with the network. Two case studies, a hump marshalling yard (mainly Single Wagon Load traffic) and a flat shunting yard (mainly intermodal traffic), were represented with state-of-the art microsimulation models, combined with innovative optimisation algorithms. Some specialistic information on the nature of the models is provided. However, the focus is oriented to railway engineers, with a description of the interactions between the models in producing outputs that are useful both to the yard dispatcher (decisions on staff, track, locomotive assignment, order of operations) and the infrastructure manager of the surrounding network (expected times of departure, availability of tracks in the yard)
Photo 3D technology applied to e-Learning tools production for animal biology
No full text[EN] The teachers from the Biology Department of the University of Lille have been developing for the last two years, a digitalization program of naturalist collections. This project aims to preserve this scientific heritage and to use it for animal and plant biology teaching. Specimens are digitalized by a photo 3D capture system, that produces a 360° and/or hemispheric images of the objects starting from high-resolution pictures. Based on the use of this particular imaging technology, teachers realized multimedia eBooks and a series of files “at the glance“ for practical works in animal biology for Bachelor students in Life Sciences. These supports, enriched by graphic complements, texts, legends and interactive animations, are available on the pedagogic platform Moodle. These digital tools are viewable on computers and can be handled on smartphones and tablets for a nomad utilisation. Students generally consider these supports useful for learning and they consult these resources before, during and after the practical sessions. This distance-learning approach gives the students a complete autonomy for practical session preparation and reviews. The innovative tools here presented constitute a useful learning complement to classical academic lectures in animal biology.The project “Mammal teeth and diets“ is funded by UNISCIEL (Université des Sciences en ligne, http://www.unisciel.fr).Sautière, P.; Delbende, C.; Deleplanque, B.; Mikolajczyk, B.; Vizioli, J. (2019). Photo 3D technology applied to e-Learning tools production for animal biology. En HEAD'19. 5th International Conference on Higher Education Advances. Editorial Universitat Politècnica de València. 921-928. https://doi.org/10.4995/HEAD19.2019.9225OCS92192
Plasma exchange in severe gastrointestinal and renal forms of Henoch-Schönlein purpura and primary IgA nephropathy. Review of the literature and results of a french retrospective study
No full textAnticipation in the Dial-a-Ride Problem: an introduction to the robustness
No full textInternational audienceThe Dial-a-Ride Problem (DARP) models an operation research problem related to the on demand transport. This paper introduces one of the fundamental features of this type of transport: the robustness. This paper solves the Dial-a-Ride Problem by integrating a measure of insertion capacity called Insertability. The technique used is a greedy insertion algorithm based on time constraint propagation (time windows, maximum ride time and maximum route time). In the present work, we integrate a new way to measure the impact of each insertion on the other not inserted demands. We propose its calculation, study its behavior, discuss the transition to dynamic context and present a way to make the system more robust
Analysis of the prion protein gene in thalamic dementia
No full textFull author list omitted for brevity. For the full list of authors, see article.Thalamic degenerations or dementias are poorly understood conditions. The familial forms are (1) selective thalamic degenerations and (2) thalamic degenerations associated with multiple system atrophy. Selective thalamic degenerations share clinical and pathologic features with fatal familial insomnia, an autosomal dominant disease linked to a mutation at codon 178 of the prion protein (PrP) gene that causes the substitution of asparagine for aspartic acid (178Asn mutation). We amplified the carboxyl terminal coding region of the PrP gene from subjects with selective thalamic dementia or thalamic dementia associated with multiple system atrophy. Three of the four kindreds with selective thalamic dementia and none of the three kindreds with thalamic dementia associated with multiple system atrophy had the PrP 178Asn mutation. Thus, analysis of the PrP gene may be useful in diagnosing the subtypes of thalamic dementia. Moreover, since selective thalamic dementia with the PrP 178Asn mutation and fatal familial insomnia share clinical and histopathologic features, we propose that they are the same disease
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