8 research outputs found
Assessment of mandibular bony healing, mandibular condyle and angulus after orthognathic surgery using fractal dimension method
No full textThis study aims to compare the trabeculation changes in the bone structure observed at the mandibular osteotomy line and the mandibular condyle in patients after single and double-jaw orthognathic surgery. The study included 38 patients (23 female, 15 m
Evaluation of bony changes observed in mid-palatal suture after rapid maxillary expansion using fractal analysis
No full textA predictive score for retinopathy of prematurity by using clinical risk factors and serum insulin-like growth factor-1 levels
No full textAIM: To detect the impact of insulin-like growth factor-1 (IGF-1) and other risk factors for the early prediction of retinopathy of prematurity (ROP) and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 levels. METHODS: The study was conducted with 127 preterm infants. IGF-1 levels in the 1st day of life, 1st, 2nd, 3rd and 4th week of life was analyzed. The score was established after logistic regression analysis, considering the impact of each variable on the occurrences of any stage ROP. A validation cohort containing 107 preterm infants was included in the study and the predictive ability of ROP score was calculated. RESULTS: Birth weights (BW), gestational weeks (GW) and the prevalence of breast milk consumption were lower, respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD) and necrotizing enterocolitis (NEC) were more frequent, the duration of mechanical ventilation and oxygen supplementation was longer in patients with ROP (P<0.05). Initial serum IGF-1 levels tended to be lower in newborns who developed ROP. Logistic regression analysis revealed that low BW (<1250 g), presence of intraventricular hemorrhage (IVH) and formula feeding increased the risk of ROP. Afterwards, the scoring system was validated on 107 infants. The negative predictive values of a score less than 4 were 84.3%, 74.7% and 79.8% while positive predictive values were 76.3%, 65.5% and 71.6% respectively. CONCLUSION: In addition to BW <1250 g and IVH, formula consumption was detected as a risk factor for the development of ROP. Breastfeeding is important for prevention of ROP in preterm infants
Non-muscle invasive bladder cancer tissues have increased base excision repair capacity
No full textThe molecular mechanisms underlying the development and progression of bladder cancer (BC) are complex and have not been fully elucidated. Alterations in base excision repair (BER) capacity, one of several DNA repair mechanisms assigned to preserving genome integrity, have been reported to influence cancer susceptibility, recurrence, and progression, as well as responses to chemotherapy and radiotherapy. We report herein that non-muscle invasive BC (NMIBC) tissues exhibit increased uracil incision, abasic endonuclease and gap-filling activities, as well as total BER capacity in comparison to normal bladder tissue from the same patient (p<0.05). No significant difference was detected in 8-oxoG incision activity between cancer and normal tissues. NMIBC tissues have elevated protein levels of uracil DNA glycosylase, 8-oxoguanine DNA glycosylase, AP endonuclease 1 and DNA polymerase beta protein. Moreover, the fold increase in total BER and the individual BER enzyme activities were greater in high-grade tissues than in low-grade NMIBC tissues. These findings suggest that enhanced BER activity may play a role in the etiology of NMIBC and that BER proteins could serve as biomarkers in disease prognosis, progression or response to genotoxic therapeutics, such as Bacillus Calmette-Guerin.Muftuoglu, M (corresponding author), Acibadem Mehmet Ali Aydinlar Univ, Dept Med Biotechnol, TR-34752 Istanbul, Turkey ; Acibadem Mehmet Ali Aydinlar Univ, Dept Mol Biol & Genet, TR-34752 Istanbul, Turkey.
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Evaluation of anterior and posterior corneal aberrations in patients with keratoconus
No full textEvaluation of anterior and posterior corneal aberrations in patients with keratoconusPoster DetailsFirst Author: E.AltinkurtTURKEYCo Author(s): O. Muftuoglu S. Karaman Erdur Abstract DetailsPurpose:To evaluate the anterior and posterior corneal aberrations in patients with keratoconus.Setting:The study is made in a tertiary referral center.Methods:100 eyes of 57 patients with clinical keratoconus and 100 eyes of 50 control patients who were refractive surgery candidates were included in this study. All eyes were evaluated before and 6-months after surgery using Placido-Scheimpflug combined topo/tomographer. Visual acuity, keratometry, anterior, posterior, and total corneal aberrations were analyzed.Results:The mean Ksteep was 48.6 ± 4.8 D in keratoconus group, and 43.2 ±2.1 D in control group. The mean anterior corneal total higher order aberration, coma, and spherical aberration were 1.83±1.39 µm, 1.44 ± 0.92 µm, 0.31 ± 0.29 µm, respectively. The mean posterior corneal total higher order aberration, coma, and spherical aberration were 1.04 ± 1.63 µm, 0.36 ± 0.32 µm, 0.16 ± 0.21 µm, respectively. The mean anterior and posterior corneal total higher order aberration, coma, and spherical aberration were significantly higher than those of control groups (p˂0.05). The differences were more prominent in posterior corneal aberrations.Conclusions:Corneal higher order aberrations, particularly posterior corneal aberrations are significantly higher in eyes with keratoconus compared to normal controls
WITHDRAWN: The effect of coenzyme q10 on a rat model of oleic acid-induced acute lung injury
No full textThis article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy
Author Correction: Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy (Nature Medicine, (2022), 28, 3, (557-567), 10.1038/s41591-022-01696-4)
No full textIn the version of this article initially published, the name of the Edward P. Evans Foundation was shown incorrectly in the first sentence of the Acknowledgements. The name has been corrected in the HTML and PDF versions of the paper
Long-term evaluation of masseter muscle activity, dimensions, and elasticity after orthognathic surgery in skeletal class III patients
No full textObjective: To evaluate changes in the masseter muscle after orthognathic surgery using electromyography (EMG), ultrasonography (US), and ultrasound elastography (USE) in individuals with skeletal class III anomaly over long-term follow-up and compare with a control group. Materials and methods: The study group included 29 patients with class III dentofacial deformities scheduled to undergo orthodontic treatment and orthognathic surgery. The control group included 20 individuals with dental class I occlusion. Assessment of the masseter muscles using EMG, US, and USE was performed before orthognathic surgery (T1) and at postoperative 3 months (T2) and 1 year (T3) in the study group, and at a single time point in the control group. All assessments were performed at rest and during maximum clenching. Masseter muscle activity, dimension, and hardness were analyzed. Results: Electromyographic activity of the masseter muscle during maximum clenching was increased at postoperative 1 year but did not reach control group values. On ultrasonography, the masseter muscle showed minimal changes in dimension at postoperative 1 year compared to preoperative values and remained below control group values. The postoperative increase in masseter muscle hardness at rest and during maximum clenching persisted at postoperative 1 year. Conclusion: The results of this study suggest that after orthognathic surgery, additional interventions and much longer follow-up are needed to ensure better muscle adaptation to the new occlusion and skeletal morphology. Clinical relevance: All assessment methods are useful for comprehensively evaluating changes in the masticatory muscles after orthognathic surgery
