132 research outputs found
Erratum: Corrigendum to “Neuroprotective and anti-inflammatory properties of a novel non-thiazolidinedione PPARγ agonist in vitro and in MPTP-treated mice” (Neuroscience (2015) 302 (23–35)(S030645221500367X)(10.1016/j.neuroscience.2015.04.026))
No full textThe authors regret that Darren Fayne was not included as an author on the original publication. In addition, the affiliation for D. K. Nevin was incorrect. Drs. Carta and Fayne are joint last authors. The authorship and affiliations have been corrected. In addition, the following acknowledgment was missing: Irish Higher Education Authority's Programme for Research in Third Level Institutions (PRTLI); IRCSET EPS Postdoctoral award and an Enterprise Ireland Commercialisation Fund Proof of Concept award (PC/2008/0312). The authors would like to apologize for any inconvenience caused
Nevin\u27s History: A Novel of Texas by Jim Sanderson (review)
No full textThis novel of Borderlands violence and romance is an enjoyable read for anyone, especially those interested in Texana. The author, writing as if he is the main character, Andrew Nevin, gives a sense of authenticity in his first-person account. One could hardly miss parallels between an impending second war with Mexico following a Texas Ranger invasion into Mexico and the current war in Iraq. The consumption-ridden Texas Ranger, Captain McNelly, who is also a Baptist preacher, when home from his campaigns, believes he is on a crusade and that God is on his side, so whatever happens on the border will somehow turn out well. A young newspaper reporter and college-educated journalist from back East, Andrew Nevin is less complacent and vows to do all he can to stop the impending war
A short history of land settlement in Tasmania
No full textStudents of the history of Tasmania know that
Governor King, in Sydney, upon hearing that a French
expedition was lingering suspiciously about Van Diemen's
Land and the adjacent islands, decided to forestall
them, and in fear of losing British territory
despatched, in 1803, a small band of military officers,
soldiers, prisoners, and settlers to take possession of
and settle upon this island. This book details the history of land settlement from the early days of settlement. The author
endeavours to show how the
land in this island has been gradually disposed of,
first by free grants, and then by purchase on long
terms of credit.
At the time of writing this process been carried on for 134 years
and most of the good Crown land had been selected :
there is still, however, a considerable area of second
and third class country in this State, and if the scientists
who are striving to turn all the land in this
State to a good account can make any suggestions
of a practical nature as to how it may be profitably
treated, the native youth of Tasmania may still be able
to purchase on long terms and make a living in his
native State
A game-theoretic approach to efficient power control in CDMA data networks
No full textDönmez, Nevin (Dogus Author) -- Conference full title: 2011 International Symposium on Innovations in Intelligent Systems and Applications (INISTA 2011) Istanbul, Turkey, 15 - 18 June 2011Game theory is a branch of mathematics and is a powerful tool for analyzing resource conflicts. In wireless communication systems, power and bandwidth (spectrum) are two fundamental and conflicting resources. Efficient use of these resources in the operation of wireless communication systems is challenging. In this paper, the application of game theory for studying uplink power control in code-division multiple-access (CDMA) networks is proposed. Power control problem is modeled as a N-person non-cooperative game in which each mobile user tries to maximize its own utility without any deal among the users. A utility function is defined for each user, which represents the user's choice with respect to the carrier-to-interference ratio (CIR) and the transmitter power. Two main assumptions are made about the utility function in this work. Under the two assumptions, it is shown that there exists an optimum operating point referred to as a "Nash equilibrium" that is unique. One special condition is studied by defining the utility as a linear function. This basic model covers many of the studied power control problems.TUBITAK, IEEE
Il telaio di Dolores
No full textMy dissertation clarifies the psychological importance of words and language in Dolores Prato's works Giù la piazza non c'è nessuno and Le ore. An analysis of these works helps to demonstrate the decisive impact that language had on Prato's perception of her childhood. Fortunately, this analysis was made lucid by the "unfortunate" editorial cuts that Natalia Ginzburg made in Giù la piazza non c'è nessuno as published in 1980.
For both editorial conviction and personal ideas on what literature is, Ginzburg decided to reduce the original manuscript by two thirds and in the process eliminated most of the linguistic richness of the author's original manuscript. This reduction clearly demonstrates Ginzburg's benightedness of the psychological involvement that Prato's childhood language had in her impulse to start writing in the first place.
Prato's negation of her childhood language, and later recuperation of that language in the original manuscript resulted in Prato rediscovering her identity, i.e., the identity of her childhood. In fact, to recuperate her childhood Prato reconciled herself with her past and in the process regained the language of Treia, the small village where she spent the first ten years of her life. The prohibition of the Treia dialect at Prato's local boarding school and the editorial cuts made by Natalia Ginzburg were both done for reasons of linguistic prestige. Therefore, Prato's boarding school linguistic proscriptions as well as these editorial interdictions represent "violent acts" against the maintenance, recuperation and rediscovery of that childhood identity.
Ultimately, given the history of publishing houses at the time the book was published, without Natalia Ginzburg's editorial cuts the book would have never come out. Therefore, while we can debate the type of cuts that were made, what we cannot debate is that without Ginzburg's drastic reduction of Prato's book it never would have come to light.Ph.D.Includes bibliographical references (p. 218-225)
Characterization of the interaction of daptomycin with bacterial liposomal analogues
No full textEfforts to curb the prevalence of antibiotic resistant bacteria are unable to keep up with the aggressive adaptation of these bacterial species to existing antibiotics. Therefore, examining the interaction of existing antibiotics with bacteria may reveal previously unknown bacterial susceptibilities. Daptomycin is a typical second-line treatment for antibiotic-resistant gram positive bacterial strains, like methicillin-resistant Staphylococcus aureus (MRSA). Its proposed mechanism of action is to bind to the negatively charged phosphatidyglycerol (PG) head groups of the bacterial cytoplasmic membrane via a calcium ion dependent process. However, the specific mechanisms by which daptomycin exerts its bacteriocidality are currently unknown. It has been hypothesized that bacterial membrane rigidity may have an effect on susceptibility to daptomycin. Additionally, there is evidence to suggest that the charge of the bacterial membrane charge affects daptomycin's mechanism of action. Our study aims to systematically analyze the interaction of daptomycin with liposomal bacterial analogues by varying the rigidity and the zeta potential of the liposomes. Our results show possible mechanisms for targeting daptomycin resistance in gram positive bacteria.M.S.Includes bibliographical referencesby Nevin Varghes
Overlapping Clusters Algorithm in Ad Hoc Networks
No full textAydın, Nevin (Arel Author) --- Conference: Global Telecommunications Conference (GLOBECOM 2010). Miami, FL, 6-10 Dec. 2010.Clustering allows efficient data routing and multi-hop communication among the nodes. In this paper, we propose Overlapping Clusters Algorithm (OCA) for mobile ad hoc networks. The goal of OCA is to achieve network reliability and load balancing. The algorithm consists of two discrete phases. The start-up phase takes battery and bandwidth capacity, transmission range, density, mobility, and buffer occupancy as input parameters to perform initial clustering for the entire network. The maintenance phase monitors the status of the network and keeps the network topology updated through local and global re-clustering. We compare the performance of OCA with Lowest ID, Highest Degree, WCA, and LCC algorithms in YAES simulator. The simulation results show that OCA outperforms all the compared algorithms in terms of network reliability and load distribution. The average numbers of global re-clusterings and reaffiliations were much lower in OCA than the other algorithms. However, OCA generates a larger number of clusters, which is expected considering that the nodes are allowed to be members of multiple clusters at the same time
Routing protocols in ad hoc networks: A survey
No full textAydın, Nevin (Arel Author)Ad hoc wireless networks perform the difficult task of multi-hop communication in an environment without a dedicated infrastructure, with mobile nodes and changing network topology. Different deployments exhibit various constraints, such as energy limitations, opportunities, such as the knowledge of the physical location of the nodes in certain scenarios, and requirements, such as real-time or multi-cast communication. In the last 15 years, the wireless networking community designed hundreds of new routing protocols targeting the various scenarios of this design space. The objective of this paper is to create a taxonomy of the ad hoc routing protocols, and to survey and compare representative examples for each class of protocols. We strive to uncover the requirements considered by the different protocols, the resource limitations under which they operate, and the design decisions made by the authors
Positivism's problem with the plenitude of principles
No full textRonald Dworkin's anti-positivist argument from theoretical disagreement (ATD) in Law's Empire (1986) was one of the most significant volleys levied against legal positivism in the twentieth century. Dworkin argues theoretical disagreements about law pose a serious problem for legal positivists (like H.L.A. Hart) and that Dworkin's theory of law accounts for the existence of these disagreements in a way the positivist cannot. Scott Shapiro, in his book Legality (2011), argues his positivist theory of law, the Planning Theory, meets the challenge posed by ATD. In this thesis I provide two main reasons why Shapiro has not met Dworkin's challenge. First, Shapiro does not address the full force of Dworkin's challenge, which is to give a metaphysical account of law in cases of theoretical disagreements, not just a practical or epistemological account of legal reasoning in cases of theoretical disagreements. Second, Shapiro's theory by its own terms does not address all types of theoretical disagreements. Shapiro identifies theoretical disagreements with what Shapiro calls meta-interpretive disagreements. In fact, some theoretical disagreements about law are not meta-interpretive disagreements (that is, they are just plain interpretive disagreements). Therefore, the Planning Theory of law does not fully address ATD as it purports to.M.A.Includes bibliographical referencesby Nevin Edward Johnso
Collective dynamics differentiates functional divergence in protein evolution.
No full textProtein evolution is most commonly studied by analyzing related protein sequences and generating ancestral sequences through Bayesian and Maximum Likelihood methods, and/or by resurrecting ancestral proteins in the lab and performing ligand binding studies to determine function. Structural and dynamic evolution have largely been left out of molecular evolution studies. Here we incorporate both structure and dynamics to elucidate the molecular principles behind the divergence in the evolutionary path of the steroid receptor proteins. We determine the likely structure of three evolutionarily diverged ancestral steroid receptor proteins using the Zipping and Assembly Method with FRODA (ZAMF). Our predictions are within ~2.7 Å all-atom RMSD of the respective crystal structures of the ancestral steroid receptors. Beyond static structure prediction, a particular feature of ZAMF is that it generates protein dynamics information. We investigate the differences in conformational dynamics of diverged proteins by obtaining the most collective motion through essential dynamics. Strikingly, our analysis shows that evolutionarily diverged proteins of the same family do not share the same dynamic subspace, while those sharing the same function are simultaneously clustered together and distant from those, that have functionally diverged. Dynamic analysis also enables those mutations that most affect dynamics to be identified. It correctly predicts all mutations (functional and permissive) necessary to evolve new function and ~60% of permissive mutations necessary to recover ancestral function
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