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Figure 4
No full textFigure 4. Doxorubicin cell uptake and efficacy under static and flow conditions. (4B) Fluorescence-based quantification of doxorubicin cell uptake in OVCAR-3 and Caov-3 cells under static and flow conditions. (4C) Doxorubicin dose-response curves in static OVCAR-3 and Caov-3 cultures. Survival fractions of (4D) OVCAR-3 and (4E) Caov-3 cells treated with doxorubicin at concentrations close to their respective IC50 values under static conditions (0.31 µM for the OVCAR-3s, 0.16 µM for Caov-3s) for 72 h under static and flow conditions
Figure 5
No full textFig. 5 Effects of 0.01% Intralipid on the efficacy of PDT in ovarian cancer cell lines. (a) Dose-response curves for OVCAR-3, Caov-3, OVCAR-8 and OVCAR-5 cells treated with PDT using 0.125 μM BPD alone (0%, gray) or with 0.01% Intralipid (purple), where BPD was incubated with cells for 90 min, and Intralipid was added prior and removed immediately after irradiation. (b) Dose-response curves under the same conditions as in (a), but and Intralipid were left in the plates for 72 h post-irradiation. (c) Effect of post-irradiation presence of PDT-exposed Intralipid at a 0.1 J/cm2 across the four cell lines
Figure 1
No full textFig. 1 Effects of Intralipid on the optical properties and photodynamic RMS generation of BPD. (a) Absorbance and (b) fluorescence emission spectra of 1 µM BPD. (c) Aggregation-induced fluorescence quenching of BPD. Photodynamically generated (d) singlet oxygen and (e) hydroxyl radical/peroxynitrite. (f) Photobleaching of BPD following 0-5 J/cm2 of 690 nm light exposure
Figure 2
No full textFigure 2. BPD-PDT dose-responses in OVCAR-3 and Caov-3 cells under static and flow conditions. (2B) BPD-PDT dose-response curves in static OVCAR-3 and Caov-3 cultures. (2C, 2D, 2E) Survival fractions of OVCAR-3 cells treated with 0.1, 0.25, 0.5 J/cm2 and (2F) Caov-3 cells treated with 0.1 J/cm2 BPD-PDT under flow conditions
Figure 6
No full textFig. 6 Effects of photoexposed BPD, Intralipid, and BPD–Intralipid mixtures on cell survival in ovarian cancer lines. (a) Experimental workflow schematic (created using BioRender). Survival fractions for (b) OVCAR-3, (c) Caov-3, (d) OVCAR-8, and (e) OVCAR-5 cells. Statistics: Each point represents the mean of an independent experiment, each performed in duplicate; error bars indicate the standard error of the mean
Figure 3
No full textFigure 3. Cisplatin cell uptake and efficacy under static and flow conditions. (3B) Cisplatin cell uptake in OVCAR-3 and Caov-3 cells under static and flow conditions quantified using ICP-MS. (3C) Cisplatin dose-response curves in static OVCAR-3 and Caov-3 cultures. Survival fractions of (3D) OVCAR-3 and (3E) Caov-3 treated with 3.13 µM cisplatin for 72 h under static and flow conditions
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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