72 research outputs found
4. La construction économique et politique de la catégorie « étranger » en Côte d’Ivoire
No full textDesign, synthesis and biological study of imidazo[4,5-c]-1,6-naphthyridin-2(1H)-one derivatives with potential antiproliferative activities
No full textLa protéine kinase constitue une cible prometteuse pour le traitement de nombreuses pathologies cancéreuses. Enzymes réalisant la phosphorylation des protéines en transférant un groupement phosphate de l’ATP vers une protéine substrat. Cette dernière effectue alors un changement conformationnel qui lui confère de nouvelles fonctions. Si leur action s’effectue sur un acide aminé phénolique, on parlera de tyrosine kinase (TK) mais si elle s’effectue sur un acide aminé alcoolique non-aromatique, on parlera de sérine/thréonine kinase (STK). L’inhibition de son activité représente un enjeu important dans la découverte de nouvelles molécules anticancéreuses grâce notamment à la connaissance de leur organisation structurale. L’idée d’origine était de prendre appui sur une structure d’origine marine pour développer un travail de « drug discovery ». Il a été choisi de partir de la structure des grossularines A et B extraites d’un tunicier marin (Dendrodoa grossularia) comme modèle puisque nous avions de l’antériorité dans les travaux sur ce type de structure. Ceci a permis d’envisager de mettre au point des analogues et/ou dérivés de ces grossularines, avec, en série pyridazinoindole, l’identification de hits sur PI3K ou DYRK1A. Notre travail porte sur la synthèse de nouvelles molécules originales en série imidazo-naphtyridinones et analogues structuraux potentiellement inhibitrices des Kinases. Les composés synthétisés ont été évalués en parallèle par la Station Biologique de Roscoff sur un panel de kinases (HASPIN, CLK1, DYRK1A, CDK5, CDK9, et GSK3α/β et CK1).Protein kinase is a promising target for the treatment of many cancer pathologies. Enzymes effecting phosphorylation of proteins by transferring a phosphate group of ATP to a substrate protein. The latter then makes a conformational change that gives it new functions. If their action is performed on a phenolic amino acid, it will be called tyrosine kinase (TK) but if it is performed on a non-aromatic alcoholic amino acid, it will be called serine / threonine kinase (STK). The inhibition of its activity represents an important stake in the discovery of new anticancer molecules, thanks in particular to the knowledge of their structural organization. The original idea was to build on a marine-based structure to develop a drug discovery work. It was chosen from the structure of the grossularines A and B extracted from a marine tunicate (Dendrodoa grossularia) as a model since we had anteriority in the work on this type of structure. This made it possible to envisage the development of analogues and / or derivatives of these grossularins, with, in series pyridazinoindole, the identification of hits on PI3K or DYRK1A. Our work focuses on the synthesis of new original imidazo-naphthyridinone series molecules and structural analogues potentially inhibitory to kinases. The synthesized compounds were evaluated in parallel by the Roscoff Biological Station on a panel of kinases (HASPIN, CLK1, DYRK1A, CDK5, CDK9, and GSK3α/β and CK1)
La pyélonéphrite xanthogranulomateuse
No full textMrs LF 46 years old, with no particular history. She presented with left lower back pain. Clinically she was febrile at 38.8°C, dipstick urinalysi (nitrites, leukocytes +). Physical examination revealed pain during palpation over the left lumbar region. Laboratory tests objectified leukocytosis 22400/mm3, C-reactive protein (CRP) levels of 124 mg/l, and urinalysis test revealed multiple-antibiotic-resistant Escherichia Coli infection in the urine. Radiologically, abdominal ultrasound highlighted a significant left pelvicalyceal dilation with finely echogenic content and reduced cortical index. The CT urography showed increased left kidney size, seat of multiple intraparenchymal fluid, pseudo-cystics, heterogeneous and compartmentalized cavities, with major parenchymal atrophy, excretory delay, and significant perirenal fat infiltration associated with lithiasis of the lumbar ureter measuring 12 mm. The scannographic image allowed us to suggest the following diagnosis: diffuse xanthogranulomateuse pyelonephritis (XGP), multicystic kidney with pyonephrosis, kidney tumor necrosis (clear cell carcinoma...). Radical nephrectomy was performed, the diagnosis of XGP was retained after histopathological examination of the surgical specimen.The Pan African Medical Journal 2016;2
Étude de la corrélation entre les tendances migratoires internationaux et les tendances macroéconomiques Maliennes
No full textLe Mali, pays sahélien enclavé couvrant une superficie de 1.241.238 km², est marqué par d’importants mouvements migratoires, tant sur le plan interne qu’international. Les pratiques migratoires sont anciennes, il est héritier d’un passé culturel marqué par la présence de grands empires et royaumes. Il est largement admis que les conditions socioéconomiques, politiques sécuritaires et même environnementales sont entre autres les déterminants essentiels des migrations et qu’au retour ces mouvements migratoires contribuent au développement du milieu d’origine, sinon national. C’est dans ce contexte que cet article, présente d’une part, les principaux déterminants du phénomène migratoire du Mali de la période récente en fournissant un rappel historique de systèmes migratoires au Mali, d’autre part, il abordera la question de la contribution de la migration au développement économique du pays par le biais du transfert de fonds. Les équations de modèle économétrique en série temporelle sont exposées afin de déterminer la corrélation existante entre les variables, tendances migratoires et certains indicateurs de macroéconomiques du Mali
Gap-filling of daily streamflow time series using Direct Sampling in various hydroclimatic settings
No full textComplete hydrological time series are necessary for water resources management and modeling. This can be challenging in data scarce environments where data gaps are ubiquitous. In many applications, repetitive gaps can have unfortunate consequences including ineffective model calibration, unreliable timing of peak flows, and biased statistics. Here, Direct Sampling (DS) is used as a non-parametric stochastic method for infilling gaps in daily streamflow records. A thorough gap-filling framework including the selection of predictor stations and the optimization of the DS parameters is developed and applied to data collected in the Volta River basin, West Africa. Various synthetic missing data scenarios are developed to assess the performance of the method, followed by a real-case application to the existing gaps in the flow records. The contribution of this study includes the assessment of the method for different climatic zones and hydrological regimes and for different upstream-downstream relations among the gauging stations used for gap filling. Tested in various missing data conditions, the method allows a precise and reliable simulation of the missing data by using the data patterns available in other stations as predictor variables. The developed gap-filling framework is transferable to other hydrological applications, and it is promising for environmental modeling.Accepted Author ManuscriptWater Resource
Gestion des services urbains collectifs en Côte d'Ivoire : diagnostic et éléments de politiques pour la promotion des prestataires locaux
No full textGestion des services collectifs urbains en Côte d'Ivoire : diagnostic et solutions pour la promotion des prestataires locaux; atelier de restitution des résultats de recherche, Abidjan, Novotel, 28 octobre 1996
No full textExplicit Serre weights for GL_2 via Kummer theory
No full textWe give an explicit formulation of the weight part of Serre's conjecture for GL_2 using Kummer theory. This avoids any reference to p-adic Hodge theory. The key inputs are a description of the reduction modulo p of crystalline extensions in terms of certain "G_K-Artin-Scheier cocycles" and a result of Abrashkin which describes these cocycles in terms of Kummer theory. An alternative explicit formulation in terms of local class field theory was previously given by Dembele-Diamond-Roberts in the unramified case and by the second author in general. We show that the description of Dembele-Diamond-Roberts can be recovered directly from ours using the explicit reciprocity laws of Brueckner-Shaferevich-Vostokov. These calculations illustrate how our use of Kummer theory eliminates certain combinatorial complications appearing in these two papers
Horizontal Inequalities and Violent Conflict. Côte d’Ivoire Country Paper
No full texthuman development, aid, trade, security
Explicit Serre weights for two-dimensional Galois representations
No full textWe prove the explicit version of the Buzzard–Diamond–Jarvis conjecture formulated
by Dembele et al. (Serre weights and wild ramification in two-dimensional Galois
representations, Preprint (2016), arXiv:1603.07708 [math.NT]). More precisely, we prove
that it is equivalent to the original Buzzard–Diamond–Jarvis conjecture, which was
proved for odd primes (under a mild Taylor–Wiles hypothesis) in earlier work of the
third author and coauthors
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