161,263 research outputs found
Genome epidemiology of Neisseria gonorrhoeae and SARS-CoV-2: Strain dynamics from the level of individuals to global dissemination
No full textWhole-genome sequencing technology is rapidly advancing, and genomic data is now a pivotal aid for public health agencies tracking disease outbreaks. Genomic data allows us to better understand the epidemiology, evolution, population dynamics and spread of pathogens. The field that describes the interplay between the factors mentioned above is known as phylodynamics. In this work, Osnes et al. develop and applies phylodynamic methods to the bacterium Neisseria gonorrhoeae and the virus SARS-CoV-2.
A significant challenge with N. gonorrhoeae is that it rapidly develops resistance to all available drugs for treatment. The authors collect large genomic datasets on two important lineages of N. gonorrhoeae. They estimate the ancestry of the samples and describe evolutionary events that have led to antibiotic resistance. From the ancestral trees, they describe geographical transmission dynamics and show that Asia plays a central role in the emergence of antibiotic-resistant N. gonorrhoeae. Additionally, they use genome-based transmission analysis to investigate the relative role of different infection sites in the transmission of the disease.
The SARS-CoV-2 pandemic has caused significant mortality from 2020 to 2022. One of the greatest challenges under the pandemic has been the emergence of new variants of the virus that has led to multiple epidemic waves. Osnes et al. analyze an extensive genome collection representing the second wave of infections in Norway from autumn 2020 to spring 2021. Over this period, the alpha variant arrived in Norway and quickly replaced older lineages in circulation. The authors estimate the arrival time of the alpha variant in Norway, the number of imports represented in the data, and the number of Norwegian sequences that can be attributed to each importation. They show that a small number of imports explain a high proportion of local transmissions. To perform the analyses, the authors develop an open-source R programming package
Automatische Montage von O-Ringen
No full textDie Montage von O-Ringen in Stirnflächennuten wird heute noch weitgehend manuell durchgeführt. Bisher fehlten grundlegende Untersuchungen, um das noch nicht genutzte Rationalisierungspotential ausschöpfen zu können. In dieser Arbeit werden aufbauend auf einer Analyse der manuellen Montage die wichtigsten Automatisierungshemmnisse bei der Montage von O-Ringen in Stirnflächennuten aufgezeigt. Als wesentliche technische Automatisierungshemmnisse erweisen sich das Fehlen geeigneter Fügestrategien und entsprechender Fügewerkzeuge, sowie die geringe Kenntnis der Einflußparameter auf den Fügeprozeß. Für die Aufgabenstellung 'definierte Verformung eines zunächst kreisförmigen O-Rings entsprechend einem vorgegebenen nicht kreisförmigen Nutverlauf' wurden systematisch für die Automatisierung geeignete Lösungskonzepte entwickelt. Dabei zeigte sich, daß die gewünschte Verformung durch das 'Einwalzen' des O-Rings in die Nut erreicht werden kann. Im Rahmen von theoretischen Betrachtungen und Vorvers uchen wurden die wesentlichen Einflußfaktoren auf den Fügevorgang ermittelt und deren Abhängigkeiten untersucht. Neben der Auswahl und Untersuchung des Fügeprinzips erfolgte die Konzeption des Gesamtsystems und der notwendigen Teilsysteme. Alle Teilsysteme sind in einem Gesamtaufbau integriert und anhand von repräsentativen Montageaufgaben erprobt worden
-displays and -divisible formal -modules
No full textAhsendorf T. -displays and -divisible formal -modules. Bielefeld: Universität; 2011
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
A de novo 6p interstitial deletion and a complex translocation involving chromosomes 2, 6, and 14 in a mildly developmentally delayed patient
No full textKoldioxidutsläpp för O-Ringen 2022 : Hur stort klimatavtryck har ett större orienteringsevenemang?
No full textO-Ringen är Sveriges största orienteringstävling och samlar årligen tiotusentals deltagare, vilket medför betydande koldioxidutsläpp från flera olika källor såsom transporter, boende, mat, och tillfälliga byggnationer. Denna studie syftar till att kartlägga de utsläpp som uppstod under O-Ringen 2022 i Uppsala och identifiera de största påverkanskällorna. Data samlades in från evenemangets största samarbetspartners via enkäter och e-postintervjuer, och utsläppen beräknades med hjälp av Greenhouse Gas Protocol. Resultatet visar att 99,7 % av utsläppen var indirekta Scope 3-utsläpp, där cirka 65 % kom från flygresor – varav nästan 40 % orsakades av en liten grupp deltagare som reste från länder utanför Europa. Trots dessa siffror var arrangemanget välorganiserat ur miljösynpunkt: själva evenemangsorganisationen höll sina egna utsläpp mycket låga (endast 11 ton CO₂e i Scope 1 och 2) och arbetade aktivt med klimatcertifierade leverantörer, fossilfri el, HVO-bussar samt främjande av hållbart resande. Värt att notera är att O-Ringen enbart redovisat utsläpp i egen regi, vilket innebär att exempelvis volontärers transporter samt deltagarnas resor och boenden inte styrs eller aktivt påverkas av arrangören. Studien visar på vikten av att rikta åtgärder mot deltagarnas transportval, samt att gemensam bokning av tåg eller bussresor kan vara ett sätt att minska framtida utsläpp
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Larry O. Spencer, Conference Author Presentation
No full textGen. Larry O. Spencer, USAF (Ret.), author of Dark Horse: A Journey from the Horseshoe to the Pentago
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Author Under Sail The Imagination of Jack London, 1902-1907
No full textIn this second volume of Author Under Sail Jay Williams investigates the life of Jack London as a professional writer at the turn of the 1900s, as his publications spanned The Call of the Wild to The Iron Heel and The Road. While documenting key life events, especially his rising fame, this biography explores London's necessity to illustrate the inner workings of his own vast imagination through his socialist essays and fiction.Cover -- Title Page -- Copyright Page -- Contents -- Acknowledgments -- Introduction -- 1. Howl, O Heav'nly Muse! -- 2. Jesus in the Theater of Socialism -- 3. Jack London's Place in American Literature -- 4. Theater of War, Theater at Home -- 5. Revolution, Evolution, and the Scene of Writing -- 6. The Jack London Show Goes on the Road -- 7. Red Atavisms and Revolution -- 8. Earthquake Apocalypse and Building the City, Boat, and House Beautiful -- 9. The Future of Socialism and the Death of the Individual -- 10. The Road Never Ends -- Notes -- Bibliography -- IndexIn this second volume of Author Under Sail Jay Williams investigates the life of Jack London as a professional writer at the turn of the 1900s, as his publications spanned The Call of the Wild to The Iron Heel and The Road. While documenting key life events, especially his rising fame, this biography explores London's necessity to illustrate the inner workings of his own vast imagination through his socialist essays and fiction.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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