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Michael R. Rios thanks Dr. Hector P. Garcia for the opportunity to shadow him
No full textMichael R. Rios writes to Dr. Hector P. Garcia to express his appreciation for a day they spent together. He feels honored to have had the opportunity to shadow him
Fusion of quantitative susceptibility maps and T1-weighted images improve brain tissue contrast in primates
No full textRecent progress in quantitative susceptibility mapping (QSM) has enabled the accurate delineation of submillimeter-scale subcortical brain structures in humans. However, the simultaneous visualization of cortical, subcortical, and white matter structure remains challenging, utilizing QSM data solely. Here we present TQ-SILiCON, a fusion method that enhances the contrast of cortex and subcortical structures and provides an excellent white matter delineation by combining QSM and conventional T1-weighted (T1w) images. In this study, we first applied QSM in the macaque monkey to map iron-rich subcortical structures. Implementing the same QSM acquisition and analysis methods allowed a similar accurate delineation of subcortical structures in humans. However, the QSM contrast of white and cortical gray matter was not sufficient for appropriate segmentation. Applying automatic brain tissue segmentation to TQ-SILiCON images of the macaque improved the classification of subcortical brain structures as compared to the single T1 contrast by maintaining an excellent white to cortical gray matter contrast. Furthermore, we validated our dual-contrast fusion approach in humans and similarly demonstrated improvements in automated segmentation of the cortex and subcortical structures. We believe the proposed contrast will facilitate translational studies in nonhuman primates to investigate the pathophysiology of neurodegenerative diseases that affect subcortical structures such as the basal ganglia in humans
An anesthetic protocol for preserving functional network structure in the marmoset monkey brain
No full textAbstract Initiatives towards acquiring large-scale neuroimaging data in non-human primates promise improving translational neuroscience and cross-species comparisons. Crucial among these efforts is the need to expand sample sizes while reducing the impact of anesthesia on the functional properties of brain networks. Yet, the effects of anesthesia on non-human primate brain networks remain unclear. Here, we demonstrate using functional magnetic resonance imaging (fMRI) at 9.4 tesla that isoflurane anesthesia induces a variety of brain states in the marmoset brain with dramatically altered functional connectivity profiles. As an alternative, we recommend using a continuous infusion of the sedative medetomidine, supplemented with a low concentration of isoflurane. Using this protocol in eight marmosets, we observed robust visual activation during flickering light stimulation and identified resting-state networks similar to the awake state. In contrast, isoflurane alone led to a suppressed visual activation and the absence of awake-like network patterns. Comparing states using a graph-theoretical approach, we confirmed that the structure of functional networks is preserved under our proposed anesthesia protocol but is lost using isoflurane alone at concentration levels greater than 1%. We believe that the widespread adoption of this protocol will be a step towards advancing translational neuroscience initiatives in non-human primate neuroimaging. To promote the collaborative use of neuroimaging resources, we openly share our datasets (https://zenodo.org/records/11118775)
A paisagem de rios urbanos: A presença do rio Itajaí-Açu na cidade de Blumenau
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Arquitetura e UrbanismoOs rios têm sido uma presença constante na formação e crescimento das cidades. Desde os primórdios das civilizações, por uma questão de sobrevivência e utilidade, servem como fonte de recursos e meio de circulação. Porém, os rios urbanos são mal compreendidos. São entendidos como um limite ao crescimento das cidades, um obstáculo a ser transposto, e desta forma, não recebem tratamento adequado. Vistos como um problema de drenagem urbana, localizados em fundos de lote e tratados como local de despejos, os rios não vêm sendo considerados como elementos enriquecedores na construção da paisagem urbana. Sob o aspecto físico e da forma urbana, os rios são fortes elementos da paisagem. Eles estruturam o tecido urbano que lhes é próximo, tornando-se muitas vezes eixos de desenvolvimento do desenho da cidade. Eles delimitam a configuração urbana e, em alguns casos, servem como divisa de municípios. O desenho urbano ocasiona as transformações na paisagem, na morfologia urbana e nas áreas adjacentes aos rios. Para compreendermos a dinâmica urbana e ambiental através do tempo, mostrando como os diferentes elementos se alteram ou persistem, analisamos através de um estudo de caso, as transformações que ocorreram no Rio Itajaí-Açu, na cidade de Blumenau/SC, desde a fundação até os dias atuais
Michael Rodriguez interviews fiction writer Michael Kimball
No full textAuthor Michael Kimball talks about moving away from Michigan to become a successful writer, his education, the fiction reading series he has started in Baltimore, the life-story-on-postcard project, and his book "Dear everybody." Kimball is interviewed by Michigan State University Librarian Michael Rodriguez for the Michigan State University Libraries' Michigan Writers Series
Dynamic reconfiguration of macaque brain networks during natural vision
No full text\ua9 2021 The AuthorsNatural vision engages a wide range of higher-level regions that integrate visual information over the large-scale brain network. How interareal connectivity reconfigures during the processing of ongoing natural visual scenes and how these dynamic functional changes relate to the underlaying anatomical links between regions is not well understood. Here, we hypothesized that macaque visual brain regions are poly-functional sharing the capacity to change their configuration state depending on the nature of visual input. To address this hypothesis, we reconstructed networks from in-vivo diffusion-weighted imaging (DWI) and functional magnetic resonance imaging (fMRI) data obtained in four alert macaque monkeys viewing naturalistic movie scenes. At first, we characterized network properties and found greater interhemispheric density and greater inter-subject variability in free-viewing networks as compared to structural networks. From the structural connectivity, we then captured modules on which we identified hubs during free-viewing that formed a widespread visuo-saccadic network across frontal (FEF, 46v), parietal (LIP, Tpt), and occipitotemporal modules (MT, V4, TEm), and that excluded primary visual cortex. Inter-subject variability of well-connected hubs reflected subject-specific configurations that largely recruited occipito-parietal and frontal modules. Across the cerebral hemispheres, free-viewing networks showed higher correlations among long-distance brain regions as compared to structural networks. From these findings, we hypothesized that long-distance interareal connectivity could reconfigure depending on the ongoing changes in visual scenes. Testing this hypothesis by applying temporally resolved functional connectivity we observed that many structurally defined areas (such as areas V4, MT/MST and LIP) were poly-functional as they were recruited as hub members of multiple network states that changed during the presentation of scenes containing objects, motion, faces, and actions. We suggest that functional flexibility in macaque macroscale brain networks is required for the efficient interareal communication during active natural vision. To further promote the use of naturalistic free-viewing paradigms and increase the development of macaque neuroimaging resources, we share our datasets in the PRIME-DE consortium
Michael Rodriguez interviews author Paul Clemens
No full textAuthor Paul Clemens talks about his book "Made in Detroit," the genre of memoir, and writing about race. Clemens is interviewed by Michigan State University Librarian Michael Rodriguez for the MSU Libraries' Michigan Writers Series. Held in the MSU Main Library
Michael Rodriguez interviews author Tom Springer
No full textAuthor Tom Springer is interviewed about his writing career and his newest book "Looking for hickories". Springer talks about his career following after earning an Environmental Journalism degree from Michigan State University. He calls his genre "creative non-fiction" and explains how he weaves his memories into his books about life in rural and wild Michigan. Part of the Michigan State University Libraries' Michigan Writers Series. Springer is interviewed by Librarian Michael Rodriguez
O oitavo dia: produção de sentidos identitários na Colônia Entre Rios-PR (segunda metade do século XX)
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-Graduação em História.Esta pesquisa objetiva analisar como a identificação suábios do Danúbio é elaborada e cristalizada nos discursos sobre o grupo e sobre a Colônia Entre Rios, localizada no município de Guarapuava, Centro-Sul do Paraná. A formação da colônia se deu a partir de 1951, com a vinda de cerca de 500 famílias de refugiados da Segunda Guerra Mundial, oriundos da antiga Iugoslávia, Hungria e Romênia. O foco de análise são os discursos que relacionam passado, presente e futuro do grupo e, assim, por meio da constituição de uma memória coletiva, constroem um sentido identitário suábio-danubiano em Entre Rios
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