170,161 research outputs found
Allgemeine Toxicologie oder Giftkunde, worin die Gifte des Mineral- Pflanzen- und Thierreichs, aus dem physiologischen, pathologischen und medizinisch- gerichtlichen Gesichtspunkte untersucht werden
No full textnach dem Französischen des ... M.P. Orfila ; mit Zusätzen und Anmerkungen begleitet von Sigism. Friedr. HermbstädtTheil 1: XIV, 368 S., 1 Taf. ; Theil 2: X, 313 S., [2] Bl. ; Theil 3: VIII, 398 S., [1] Bl. ; Theil 4: VIII, 384 S.Exlibrisetikette: "...Zu Eigen C. Hartwich" 001508935_0001 Exemplar der ETH-BIB, Rar 20976Indirekter Exlibrisstempel: "Aus dem Nachlasse des H. Prof. Hartwich erworben durch die E.T.H. 001508935_0002 Exemplar der ETH-BIB, Rar 20976Handschriftliches Exlibris: "Carl Hartwich. 71." Exemplar der ETH-BIB, Rar 2097
Data set for "Optimal wave reflection as mechanism for seagrass self-organization"
No full textAll methodological information is in the paper "Optimal wave reflection as mechanism for seagrass self-organization" by Roeland C. van de Vijsel, Emilio Hernández-García, Alejandro Orfila, Damià Gomila
to appear in Scientific Reports.Whenever you use any part of the data (scripts, figures, raw and processed data) described in this README-file, please make sure to correctly refer to this dataset, the manuscript described above and its authors.Full data set used for the following manuscript: Optimal wave reflection as mechanism for seagrass self-organization by R.C. van de Vijsel, E. Hernández-García, A. Orfila, D. Gomila, to appear in Scientific Reports (2023).
The data set contains all the necessary codes and simulation and raw data to reproduce the results discussed in the associated manuscript. Folder "Figure scripts" contains the Matlab codes and associate raw data to generates all the figures of the manuscript. Folder "v28" contains the Matlab scripts that calculate uniform basic state for a given set of
model parameters and numerically time-integrate the perturbation equations. It also contains all simulation results and figures, generated with the above Matlab scripts. Folders "v33" to "v39" contain variations of the codes in "v28".Project CYCLE (PID2021-123723OB-C22) funded by MCIN/AEI/10.13039/501100011033 and ERDF “A way of making Europe”; María de Maeztu project CEX2021-001164-M618 funded by the MCIN/AEI/10.13039/501100011033; European Union’s Horizon 2020 research and innovation programme (Grant agreement ID: 101093910, Ocean Citizen). Project LAMARCA (PID2021-123352OB-C31 and PID2021-123352OB-C32) funded by MICIN/AEI621/FEDER, UE; Project Tech2Coast (TED2021-130949B-I00) funded by MCIN/AEI,EU “NextGenerationEU/PRTR”.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001164-M618).Please, see data_description.pdf file.Peer reviewe
A shoreline detection method with X-band marine radar
No full text© 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).The assessment of morphological mapping capacity of X-band radars is performed by comparing radar-derived shoreline estimates with in-situ data measured from DGPS-RTK surveys in Cala Millor beach (October 22–24, 2018). Radar estimates are obtained by applying an automatic method based on digital image processing, threshold segmentation and first-order derivative filters on X-Band radar variance images. The study site is covered by the endemic Posidonia oceanica seagrass meadow at the seabed. It represents a challenge on the estimation of local shoreline. Results reveal that X-band radar estimate the shoreline location with a mean bias of 4.66 m, a relative error of 2.95% and a RMSE of 14.07 m. Also, the beach morphology is assessed by the identification of surrounding rocky outcrops and a submerged sandbar. Since the obtained radar estimation errors are comparable with the reported by previous studies but using video-cameras, results reveal a potential complementary use of both marine radars and optical cameras to provide higher-resolution and more accurate shoreline measurements in a broader area.This research has been possible thanks to financial support from Colombian Science and Technology Ministry Project 0376-2013 (Developing and modeling of a sea state sensor through the processing of radar signals). Wendy Navarro acknowledges financial support from Universidad del Norte, COLCIENCIAS (Call 757) and iCOOP+2016 (CSIC) fellowships. Alejandro Orfila acknowledges financial support from Projects LAMARCA (PID2021-123352OB-C31) funded by MICIN/ AEI/10.13039/5011000 11033/FEDER, UE; Tech2Coast (TED2021-130949B-I00) funded by MCIN/AEI/ 10.13039/501100011033 and by EU “NextGenerationEU/PRTR” and LIFE AdaptCalaMillor – LIFE21 GIC/ES /101074227. The authors are indebted to Universidad del Norte for providing equipment as well as to the Balearic Islands Coastal Observing System (SOCIB) for the field support during the experiments. The present research was carried out in the framework of the AEI accreditation “Maria de Maeztu Centre of Excellence” given to IMEDEA (CSIC-UIB) (CEX2021-001198).With funding from the Spanish government through the ‘María de Maeztu Unit of Excelence’ accreditation (CEX2021-001198).Peer reviewe
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Guidelines for nutritional intervention studies on BEF effectiveness with a special focus on pilot studies
No full textThe guidelines presented here have been developed through consultation with PATHWAY-27 project partners to provide practical guidance for designing, implementing and reporting pilot intervention studies using bioactive enriched foods (BEF). These guidelines update and complement previously published guidance documents, but are unique in providing practical information and troubleshooting based on the PATHWAY-27 pilot studies.
The aim of PATHWAY-27 is to evaluate the effectiveness of BEF containing docosahexaenoic acid (DHA), anthocyanins (AC) and beta-glucan (BG) alone or in combination, on improving risk factors of the metabolic syndrome (MetS). These compounds were chosen for their known effects as single compounds, and considered as ingredients of BEF in three different widely consumed food matrices (dairy, bakery and egg products). This approach of using BEF, compared to single pure compounds, will allow a better understanding of possible bioactive synergisms and bioactive-matrix interactions. This knowledge will increase the potential for exploitation of bioactive and BEF commercialization by the food industry.
A pilot trial is a small-scale study that is used to test the physiological effects and participant acceptance of prototype formulations in order to select food products to be tested in a larger scale trial. The pilot is also a great opportunity to test the data collection methods, procedures and logistics that can provide early identification of problems in order to find suitable solutions that can be implemented to improve the quality and efficiency of the main trial.
With examples gathered from the PATHWAY-27 project, this guidance document describes the requirements for the formulation and production of BEF, the design and conductance of a pilot trial, and how the data and information gathered can be used to inform further larger trials and the best practice for public reporting
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Socorros que han de darse a las personas envenenadas o asfixiadas; seguidos de los medios propios para conocer los venenos y vinos adulterados, la muerte real y la aparente. Por M.P. Orfila
No full textEnc. Past
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
In vitro oral processing of raw tomato: Novel insights into the role of endogenous fruit enzymes
No full textDuring consumption of fruits, the breakdown of the fruit tissue due to oral processing (chewing, mixing with saliva) may activate or increase the rate of endogenous enzyme activities via the disruption of the cell wall, cellular de‐compartmentalization and particle size reduction allowing the enzymes to reach their substrates. The aim of this study was to investigate the activity of one such endogenous fruit enzyme (pectin methylesterase (E.C. 3.1.1.11) during in vitro oral processing of raw tomatoes and associated changes in viscosity and microstructure. Oral processing of tomatoes purees was examined in the presence of artificial saliva at 37 ○C. In vitro oral processing was followed using immunofluorescence microscopy, apparent viscosity measurements, spectrophotometric and titrimetric techniques. Results demonstrated that pectin methylesterase had slight but significant activity in the tomato fruit during in vitro oral processing generating methanol as a function of oral processing time, which was further evidenced using immunolabelling techniques to detect methylated pectin epitopes. A significant shear‐thinning behaviour of the tomato puree was observed due to dilution and/or endogenous fruit enzyme activity. These results suggest that activity of other fruit enzymes, such as polygalacturonase, which catalysed the depolymerisation of unmethylated pectin chains might have resulted in a decrease in viscosity, which compensated for the increased potential for gel formation (if any) caused by PME. These interesting insights on role of endogenous fruit enzymes might pave the way to the understanding of fruit viscosity modification occurring in the mouth and help in rational design of new fruit based products
Arnaldo Orfila Reynal. El editor que marcó los cánones de la edición latinoamericana
No full text210 páginas. Maestría en Historiografía.La presente investigación presenta una respuesta desde la óptica de la historiografía sobre cuáles fueron los factores que se tuvieron que conjugar para que un experimentado empresario cultural argentino hubiera emergido en México como una de las figuras más dominantes de la edición en Latinoamérica, durante la segunda mitad del siglo XX. Siendo que cuando Arnaldo Orfila Reynal se hizo cargo de la dirección interina del Fondo de Cultura Económica (30 junio de 1948), no había tenido antes una experiencia previa similar administrando una casa editorial y él ya había rebasado el medio centenar de años de edad cumplidos. En este sentido fue durante su gestión al frente de esta casa editorial mexicana que construyó su fama y prestigio como editor a nivel internacional, pero el momento de su consagración como empresario editorial independiente tuvo que esperar hasta que fue removido de su cargo por una intervención presidencial, y cuando emprendió la fundación de Siglo XXI Editores (18 de noviembre de 1965). Por otra parte, el análisis de la construcción de la representación de Arnaldo Orfila como: “el decano de los editores latinoamericanos” y del primer medio siglo de su itinerario personal y profesional me permitió establecer la ruta de la investigación de la segunda parte de la tesis a partir del desarrollo de tres ejes temáticos: a) El análisis de los ciclos, las dinámicas y las coyunturas culturales, sociales y editoriales que tuvieron que conjugarse en América Latina durante la primera mitad del siglo XX, b) Los elementos particulares que aportó la institucionalización de la industria editorial en Latinoamérica que permitieron a una casa editorial como el Fondo de Cultura Económica, forjar los referentes simbólicos y concretos para la creación de una identidad colectiva tanto a nivel nacional como regional, y c) Rastrear cuáles fueron los cambios en las estrategias de la construcción de las redes de intercambio intelectual, editorial y de solidaridad personal hacia Orfila, durante su primer medio siglo de vida y, después, cuando asumió la responsabilidad de dirigir, administrar y hasta fundar nuevas casas editoriales.Esta tesis fue realizada con el apoyo del Consejo Nacional de Ciencia y Tecnología (México). CONACYT, mediante la beca (CVU) folio 229752
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