83 research outputs found
ADEM-_Supp-Table-Sept23 - Increased Intracranial Pressure in Acute Disseminated Encephalomyelitis
No full textADEM-_Supp-Table-Sept23 for Increased Intracranial Pressure in Acute Disseminated Encephalomyelitis by Rotem Orbach, Nira Schneebaum Sender, Ronit Lubetzky, and Aviva Fattal-Valevski in Journal of Child Neurology</p
Assessment of hemostatic profile in neonates with necrotizing enterocolitis using Rotational Thromboelastometry (ROTEM)
No full textBackground: This study aimed to explore the hemostatic profile of neonates with necrotizing enterocolitis (NEC) using Rotational Thromboelastometry (ROTEM) and to investigate if ROTEM parameters have the capacity to play a role in the differentiation of NEC from sepsis at the disease onset. Methods: This observational study included 62 neonates (mean gestational age 31.6 weeks and mean birth weight 1620g) hospitalized in a neonatal intensive care unit. The neonates were categorized in three groups: neonates with NEC (Bell stage II and above), neonates with sepsis and healthy neonates and they were matched 1:1:1 with regards to gestational age, delivery mode, and sex. Clinical, laboratory data as well as measurements of ROTEM parameters at disease onset were recorded. Results: ROTEM parameters differed between neonates with NEC and neonates with sepsis, indicating that NEC results in accelerated clot formation and higher clot strength compared to sepsis. The EXTEM CFT and A10 parameters demonstrated the highest diagnostic performance for NEC in terms of discrimination between NEC and sepsis (AUC, 0.997; 95% CI: 0.991–1.000 and 0.973; 95% CI: 0.932–1.000, respectively). Conclusions: Neonates with NEC manifested accelerated clot formation and higher clot strength compared to septic and healthy neonates, as these were expressed by ROTEM parameters. Impact: This work reports data on the hemostatic profile of neonates with necrotizing enterocolitis (NEC) using Rotational Thromboelastometry (ROTEM) and the capacity of ROTEM parameters in differentiating of NEC from sepsis at the disease onset. Neonates with NEC present acceleration of coagulation and exhibit a hypercoagulable profile, as this is expressed by ROTEM parameters, in comparison to septic and healthy neonates. ROTEM parameters demonstrated a good diagnostic capacity in differentiating NEC from sepsis at the disease onset. © The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2023
"Simha Rotem (1924-2018): Ad memoriam. The broom and the resilience"
No full textSimha Rotem was born in Warsaw in 1924. He was one of the most important member of the Warsaw
Ghetto uprising in April 1943. Under the cover name of Kazik. He was a leader of the young Jews who were one of the
first in Europe to rebel against the Nazi occupation. His original name is Symon Rathajzer, who upon his arrival in
Israel he changed in Simha Rotem to symbolize a new beginning. His heroic and history is full of anecdotes that
encroach of the unbelievable. Rotem came in and out of the ghetto, through the city’s sewers, besieged and burned, to
bringing news and organizing the escape of the few survivors. Thanks to him the last fighters of the ghetto succeeded in
acriding the “Aryan” area of the city, finding refuge from not Jewish people connected with the Polish resistance. In
1944 Rotem fighted in the Warsaw uprising against the Nazi occupation. He was one of the leader of the Jewish exodus
from Poland to Israel. He contributed to save thousands of people. The author died in Jerusalem in 2018
Measuring message gossiping in P2P networks and providing incentives in cryptocurrencies
No full textThesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 47-48).In this thesis, we present Plutus, an efficient and game-theoretically proven incentive mechanism for Algorand, a proof-of-stake cryptocurrency. In order to operate, Algorand requires users to constantly propagate messages but has no mechanism to incentivize users to do so. Plutus solves this problem by keeping track of each message propagation path and rewarding the users who propagated messages using a lottery. We implemented a prototype of Plutus on top of Algorand to measure the performance and overhead of Plutus. Experimental results show that with Plutus, Algorand's block confirmation time increases by only 7% and that there is no penalty on Algorand's scalability.by Rotem Hemo.M. Eng
A Transitional Gundi (Rodentia: Ctenodactylidae) from the Miocene of Israel
No full textabstract: We describe a new species of gundi (Rodentia: Ctenodactylidae: Ctenodactylinae), Sayimys negevensis, on the basis of cheek teeth from the Early Miocene of the Rotem Basin, southern Israel. The Rotem ctenodactylid differs from all known ctenodactylid species, including Sayimys intermedius, which was first described from the Middle Miocene of Saudi Arabia. Instead, it most resembles Sayimys baskini from the Early Miocene of Pakistan in characters of the m1-2 (e.g., the mesoflexid shorter than the metaflexid, the obliquely orientated hypolophid, and the presence of a strong posterolabial ledge) and the upper molars (e.g., the paraflexus that is longer than the metaflexus). However, morphological (e.g., presence of a well-developed paraflexus on unworn upper molars) and dimensional (regarding, in particular, the DP4 and M1 or M2) differences between the Rotem gundi and Sayimys baskini distinguish them and testify to the novelty and endemicity of the former. In its dental morphology, Sayimys negevensis sp. nov. shows a combination of both the ultimate apparition of key-characters and incipient features that would be maintained and strengthened in latter ctenodactylines. Thus, it is a pivotal species that bridges the gap between an array of primitive ctenodactylines and the most derived, Early Miocene and later, gundis.The article is published at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.015180
The Angiostrongylus vasorum excretory/secretory and surface proteome contains putative modulators of the host coagulation
No full textAngiostrongylus vasorum is a cardiopulmonary nematode of canids and is, among others, associated with bleeding disorders in dogs. The pathogenesis of such coagulopathies remains unclear. A deep proteomic characterization of sex specific A. vasorum excretory/secretory proteins (ESP) and of cuticular surface proteins was performed, and the effect of ESP on host coagulation and fibrinolysis was evaluated in vitro. Proteins were quantified by liquid chromatography coupled to mass spectrometry and functionally characterized through gene ontology and pathway enrichment analysis. In total, 1069 ESP (944 from female and 959 from male specimens) and 1195 surface proteins (705 and 1135, respectively) were identified. Among these were putative modulators of host coagulation, e.g., von Willebrand factor type D domain protein orthologues as well as several proteases, including serine type proteases, protease inhibitors and proteasome subunits. The effect of ESP on dog coagulation and fibrinolysis was evaluated on canine endothelial cells and by rotational thromboelastometry (ROTEM). After stimulation with ESP, tissue factor and serpin E1 transcript expression increased. ROTEM revealed minimal interaction of ESP with dog blood and ESP did not influence the onset of fibrinolysis, leading to the conclusion that Angiostrongylus vasorum ESP and surface proteins are not solely responsible for bleeding in dogs and that the interaction with the host’s vascular hemostasis is limited. It is likely that coagulopathies in A. vasorum infected dogs are the result of a multifactorial response of the host to this parasitic infection.University of Zurich, SwitzerlandBusiness Unit Animal Health, German
How Prevalent is Functional Alternative Splicing in the
No full textthis article can be found at doi: 10.1016/j.tig.2003.12.004 Corresponding author: Gil Ast ([email protected]
Listening as Contemplation: A reflexive thematic analysis of listening to modular-based compositions
No full textThis paper and the live demonstration that accompanies it constitute part of a practice-based autoethnography that focuses on an engagement with modular synthesizers in the process of composing electronic music. Driven by the author’s meditation practice, this study examines how modular-based practices might embody, articulate, and promote contemplative insights, i.e., experiential understandings that arise through meditation. To develop effective approaches for working with this concept, the author employs the enquiry cycle of self-reflection: an iterative approach borrowed from action research, divided into stages of planning, acting, and reflecting on action (Haseman, 2010). This entails developing bespoke hardware and software configurations alongside musical sketches, recording performances of those sketches, and reflecting on the recordings before repeating the cycle. In this process, different methods for capturing data are used at different stages of the cycle, including text-based logs, patch diagrams and audio-visual journals.
Based on autoethnographic data collected and analysed elsewhere, certain guiding principles for contemplative music making are established upon initiating the cycle. These include pattern-based repetition, gradual musical process, timbral transformation and a particular interest in spatial effects. These emphases are seen to reflect the Buddhist notion of emptiness, according to which all objects—both physical and imaginary—are empty of their own existence, products of a complex web of causes and conditions. Following these guidelines, the author suggests several modular-based tools and techniques. Sequencing, for one, is offered as a way of establishing patterns, whereas sequence operations and delay processes create permutations and a sense of polyphony through pattern-overlay. Working with the idea of space as material, the case of the Make Noise Erbe-Verb is examined due to its affordance of flexible voltage control over digital reverb parameters. Finally, the author examines working with the harmonic oscillator, a device that employs Pythagorean just intonation to create complex timbres.
Showcasing his contemplative approach for working with modular synthesizers, the author performs a selection of works in progress using the suggested setup. Much like the practice of vipassana, where attention is directed towards the flux of bodily sensations, the resultant pieces promote a shift from goal-oriented, teleological forms of listening to a moment-to-moment observation of sound as changing phenomenon
Review of David Fraser, Nazi Antisemitism and Jewish Legal Self-Defense: The Turn to Law in Liberal Democracies, 1932–39 (Abingdon, Oxon: Routledge 2024)
No full text© 2025 Taylor & Francis. This is an author produced version of a paper published in Comparative Legal History uploaded in accordance with the publisher’s self- archiving policy. The final published version (version of record) is available online at the link. Some minor differences between this version and the final published version may remain. We suggest you refer to the final published version should you wish to cite from it
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