1,720,968 research outputs found
Modulación del microambiente inflamatorio en la progresión de la enfermedad renal diabética
Get PDFEsta tesis tiene embargado el acceso al texto completo hasta el 05-06-2020Tesis doctoral inédita cotutelada por la Universidad Austral de Chile y la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de lectura: 05-12-2018La Diabetes Mellitus es un problema de salud pública mundial, siendo la Nefropatía Diabética (ND) la principal causa de Enfermedad Renal Terminal. Aunque los actuales tratamientos enlentecen la evolución de la enfermedad, es necesario establecer nuevas estrategias terapéuticas en estadios tempranos, con el fin promover la renoprotección y retrasar la terapia de reemplazo renal.
La activación de la vía NF-κB y JAK/STAT contribuyen significativamente en la progresión del daño renal a través de la generación de una cascada inflamatoria, que puede ser controlada por diferentes mecanismos, entre los que se encuentran los péptidos inhibidores transcripcionales NBD y MiS1, respectivamente.
A través de la caracterización del daño renal temprano determinado en el modelo BTBR ob/ob, se propuso un tratamiento de 7 semanas de duración por administración intraperitoneal de péptidos NBD y MiS1 a partir de la 6ª semana. Se monitoreo glicemia capilar, peso corporal, proteinuria y parámetros bioquímicos. Los resultados muestran reducción de la proteinuria y daño histopatológico con mejora en el recuento de podocitos en ambos tratamientos, sin modificación de parámetros metabólicos. Por su parte, el péptido MiS1 reduce la microinflamación renal por inhibición de la actividad de STAT1/STAT3, restricción de la infiltración de monocitos/macrófagos F4/80+ y linfocitos T CD3+ y reducción en la expresión génica de citoquinas y quimioquinas pro-inflamatorias. Reducción del estrés oxidativo por regulación del eje NRF2/HO-1, que restringe la producción de anión superóxido y modula la expresión génica de marcadores del balance REDOX. Efectos anti-lipotóxicos fueron observados tanto a nivel renal como a nivel hepático.
De acuerdo a estos resultados, el péptido MiS1 es efectivo en modular el microambiente inflamatorio, oxidativo y lipotóxico en una etapa temprana de daño renal en el modelo BTBR ob/ob.Diabetes Mellitus is a global public health problem, with Diabetic Nephropathy (DN) being the main cause of end-stage kidney disease. Although current treatments deaccelerate the progression of the disease, it is necessary to define new therapeutic strategies in early stages, in order to promote the renoprotection and delay the renal replacement therapy.
Activation of the NF-κB and JAK/STAT pathway significantly contributes to the progression of kidney damage through the generation of an inflammatory cascade, which can be controlled by different mechanisms, among which are the transcriptional inhibitor peptides NBD and MiS1, respectively.
Through the characterization of early renal damage determined in the BTBR ob / ob model, a 7-week treatment was proposed by intraperitoneal administration of NBD and MiS1 peptides beginning at the 6th week. glycemia, body weight, proteinuria and biochemical parameters were monitored each week. The results showed reduction of proteinuria and histopathological damage with improvement in podocyte count in both treatments, without modification of metabolic parameters. On the other hand, the MiS1 peptide reduced renal microinflammation by inhibiting the activity of STAT1/STAT3, restricting the infiltration of monocytes/macrophages F4/80+ and CD3+ T lymphocytes and reducing the gene expression of proinflammatory cytokines and chemokines. Reduction of oxidative stress by NRF2/HO-1 axis regulation, which restricts the production of superoxide anion and modulates the gene expression of REDOX balance markers was demostrated. Anti-lipotoxic effects were observed both in renal and hepatic level.
According to these results, the MiS1 peptide is effective in modulating the inflammatory, oxidative and lipotoxic microenvironment at an early stage of renal damage in the BTBR ob/ob model
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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