982 research outputs found
[14C]Fluciclovine (alias anti-[14C]FACBC) uptake and ASCT2 expression in castration-resistant prostate cancer cells．
No full text金沢大学博士（保健学）博士論文本文Full 以下に掲載：Nuclear Medicine and Biology 42(11) pp.887-892 2015. Elsevier. 共著者：Masahiro Ono, Shuntaro Oka, Hiroyuki Okudaira, Takeo Nakanishi, Atsushi Mizokami, Masato Kobayashi, David M. Schuster, Mark M. Goodman, Yoshifumi Shirakami, Keiichi Kawaidoctoral thesi
[14C]Fluciclovine (alias anti-[14C]FACBC) uptake and ASCT2 expression in castration-resistant prostate cancer cells．
No full text博士論文本文Full 以下に掲載：Nuclear Medicine and Biology 42(11) pp.887-892 2015. Elsevier. 共著者：Masahiro Ono, Shuntaro Oka, Hiroyuki Okudaira, Takeo Nakanishi, Atsushi Mizokami, Masato Kobayashi, David M. Schuster, Mark M. Goodman, Yoshifumi Shirakami, Keiichi Kawa
<Original Article> Effects of anti-inflammatory drugs and ONO-2235 on lens aldose reductase and on sorbitol accumulation in red blood cells
No full textAnti-inflammatory drugs and ONO-2235 were tested for their ability to inhibit lens aldose reductase and sorbitol accumulation in red blood cells. Sulindac, an anti-inflammatory drug, and ONO-2235 were shown to be potent inhibitors of aldose reductases from human cataractous lenses, bovine lenses and rat lenses. ONO-2235 was the most potent inhibitor with IC50 of 2×10^-8 M, using human lens aldose reductase. Sulindac and ONO-2235 also inhibited the accumulation of sorbitol in human red blood cells. The IC50s were 6.2×10^-6 M, and 6×10^-6 M, respectively. Similarly, indomethacin and its prodrug, acemetacine, inhibited both aldose reductase in rat lens and sorbitol accumulation in human red blood cells. Furthermore, in diabetic rats, sulindac significantly suppressed sorbitol accumulation in red blood cells and sciatic nerves. These results suggest that sulindac as well as ONO-2235 can be useful in preventing chronic diabetic complications
<Original Article> Effects of anti-inflammatory drugs and ONO-2235 on lens aldose reductase and on sorbitol accumulation in red blood cells
No full textAnti-inflammatory drugs and ONO-2235 were tested for their ability to inhibit lens aldose reductase and sorbitol accumulation in red blood cells. Sulindac, an anti-inflammatory drug, and ONO-2235 were shown to be potent inhibitors of aldose reductases from human cataractous lenses, bovine lenses and rat lenses. ONO-2235 was the most potent inhibitor with IC50 of 2×10^-8 M, using human lens aldose reductase. Sulindac and ONO-2235 also inhibited the accumulation of sorbitol in human red blood cells. The IC50s were 6.2×10^-6 M, and 6×10^-6 M, respectively. Similarly, indomethacin and its prodrug, acemetacine, inhibited both aldose reductase in rat lens and sorbitol accumulation in human red blood cells. Furthermore, in diabetic rats, sulindac significantly suppressed sorbitol accumulation in red blood cells and sciatic nerves. These results suggest that sulindac as well as ONO-2235 can be useful in preventing chronic diabetic complications
Correction to: Comparison of glycyrrhizin content in 25 major kinds of Kampo extracts containing Glycyrrhizae Radix used clinically in Japan
No full textThe article Comparison of glycyrrhizin content in 25 major kinds of Kampo extracts containing Glycyrrhizae Radix used clinically in Japan, written by Mitsuhiko Nose, Momoka Tada, Rika Kojima, Kumiko Nagata, Shinsuke Hisaka, Sayaka Masada, Masato Homma and Takashi Hakamatsuka, was originally published Online First without open access. After publication in volume 71, issue 4, page 711–722 the author decided to opt for Open Choice and to make the article an open access publication. Therefore, the copyright of the article has been changed to © The Author(s) 2018 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.</jats:p
“Masato de Yuca” and “Chicha de Siete Semillas” Two Traditional Vegetable Fermented Beverages from Peru as Source for the Isolation of Potential Probiotic Bacteria
No full textOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This research was funded by the Ibero-American Programme on Science and Technology for Development (CYTED), grant number 917PTE0537. The Spanish team was funded by the “Agencia Estatal de Investigación” and the “Fondo Europeo de Desarrollo Regional” (AEI/FEDER, UE), grant number PCIN2017-075″. The Peruvian team was funded by the National Council of Science and Technology and Innovation of Peru through its execution unit National Fund for Scientific, Technological and Technological Innovation (CONCYTEC/FONDECYT), grant No. 001–2017.In this work, two Peruvian beverages “Masato de Yuca,” typical of the Amazonian communities made from cassava (Manihot esculenta), and “Chicha de Siete Semillas,” made from different cereal, pseudo-cereal, and legume flours, were explored for the isolation of lactic acid bacteria after obtaining the permission of local authorities following Nagoya protocol. From an initial number of 33 isolates, 16 strains with different RAPD- and REP-PCR genetic profiles were obtained. In Chicha, all strains were Lactiplantibacillus plantarum (formerly Lactobacillus plantarum), whereas in Masato, in addition to this species, Limosilactobacillus fermentum (formerly Lactobacillus fermentum), Pediococcus acidilactici, and Weissella confusa were also identified. Correlation analysis carried out with their carbohydrate fermentation patterns and enzymatic profiles allowed a clustering of the lactobacilli separated from the other genera. Finally, the 16 strains were submitted to a static in vitro digestion (INFOGEST model) that simulated the gastrointestinal transit. Besides, their ability to adhere to the human epithelial intestinal cell line HT29 was also determined. Following both procedures, the best probiotic candidate was Lac. plantarum Ch13, a robust strain able to better face the challenging conditions of the gastrointestinal tract and showing higher adhesion ability to the intestinal epithelium in comparison with the commercial probiotic strain 299v. In order to characterize its benefit for human health, this Ch13 strain will be deeply studied in further works. © 2021, The Author(s).Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concyte
Financing small and medium sized enterprises for sustainable development : a view from the Asia-Pacific region
No full textMacroeconomic Policy and Development Division, working paper series.This discussion paper was prepared for ESCAP by Nick Freeman, Independent Economic Development Consultant.
The author gratefully acknowledges the contributions made by Masato Abe, Sailendra Narain, Michael Troilo and J. S. Juneja
Minimization problem on the Hardy-Sobolev inequality and on the Sobolev embedding for Lebesgue space with variable exponent
No full textEnvironmental Violence in Minamata: Responsibility, Resistance, and Religiosity in the Case of Ogata Masato and Hongan no Kai
No full textThe small town of Minamata is infamous for the industrial disease named after the city. This disease resulted from having ingested methyl mercury, a substance released for more than three decades by a factory owned by the Chisso Corporation. Upon entering the human body, mercury affects the nervous system, resulting in paralysis, and often leading to a slow death. Examining how such violence was inflicted on human beings and on the environment involves a complex array of economic, environmental, and sociocultural issues, all revolving around the notions of justice and responsibility. This article analyzes the local residents’ responses to the irreparable damage done to them, focusing in particular on the thoughts and actions put forward by Ogata Masato and a group called Hongan no kai, who chose to carve bodhisattva statues. Investigating the victims’ religiosity, the author argues that the praxis put forward by the Minamata people resonates with the perspective articulated by Italian philosopher Giorgio Agamben. After having witnessed how justice had been exhausted and their case had been lost in the Japanese legal system, the victims showed their resilience in coming up with original responses, which also offer valuable insight into current discussions centered on environmental ethics
Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia
No full textPreKURA:1657On behalf of the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group:
Toshiharu Ninomiya, Mao Shibata, Takanori Honda, Jun Hata, Tomoyuki Ohara, Masato Akiyama, Shigeyuki Nakaji, Koichi Murashita, Tatsuya Mikami, Kaori Sawada, Shintaro Yokoyama, Tetsuya Maeda, Naoki Ishizuka, Hiroshi Akasaka, Yasuo Terayama, Hisashi Yonezawa, Junko Takahashi, Kenjiro Ono, Moeko Noguchi-Shinohara, Kazuo Iwasa, Sohshi Yuki-Nozaki, Masahito Yamada, Masaru Mimura, Shogyoku Bun, Hidehito Niimura, Ryo Shikimoto, Hisashi Kida, Kenji Nakashima, Yasuyo Fukada, Hisanori Kowa, Toshiya Nakano, Kenji Wada, Masafumi Kishi, Tomoki Ozaki, Ayumi Tachibana, Yuta Yoshino, Jun-ichi Iga, Shu-ichi Ueno, Minoru Takebayashi, Naoto Kajitani, Yusuke Miyagawa, Tomohisa Ishikawa, Seiji Yuki, Ryuji Fukuhara, Asuka Koyama, Mamoru Hashimoto, Manabu Ikeda, Yoshihiro Kokubo, Kazuhiro Uchida, Midori Esaki, Yasuyuki Taki, Yasuko Tatewaki, Benjamin Thyreau, Hisako Yoshida, Kaori Muto, Yusuke Inoue, Izen Ri, Yukihide Momozawa, Chikashi Terao, Michiaki Kubo & Yutaka Kiyoharajournal articl
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