3,557 research outputs found
COLLATERAL – Online Journal for Cross-Cultural Close Reading
No full textCOLLATERAL provides a multilingual online platform for encounters between text and image, between art and analysis, and between critical and artistic research. COLLATERAL is committed to modes of meticulous reading that interrogate and trace the migration of artefacts’ meanings and forms beyond cultural, linguistic, and disciplinary borders. Every issue clusters a number of interventions—artistic, literary, critical, and/or theoretical—around one text, image, or video. Staging interventions that test the limits of customary disciplinary and generic conventions, COLLATERAL affirms critical reading as a practice that confronts even as it resists a damaged world. Editorial Team
Dr. Arne De Winde (University of Leuven / PXL-MAD School of Arts, FRAME Research)
Dr. Sofie Gielis (PXL-MAD School of Arts, FRAME Research)
Dr. Oliver Kohns (University of Luxemburg)
Dra. Hannelore Roth (University of Leuven)
Prof. dr. Pieter Vermeulen (University of Leuven)
Prof. dr. Esther Peeren (University of Amsterdam — Amsterdam Centre for Globalisation Studies)
ISSN 2506-798
COLLATERAL – Online Journal for Cross-Cultural Close Reading
No full textCOLLATERAL provides a multilingual online platform for encounters between text and image, between art and analysis, and between critical and artistic research. COLLATERAL is committed to modes of meticulous reading that interrogate and trace the migration of artefacts’ meanings and forms beyond cultural, linguistic, and disciplinary borders. Every issue clusters a number of interventions—artistic, literary, critical, and/or theoretical—around one text, image, or video. Staging interventions that test the limits of customary disciplinary and generic conventions, COLLATERAL affirms critical reading as a practice that confronts even as it resists a damaged world. Editorial Team
Dr. Arne De Winde (University of Leuven / PXL-MAD School of Arts, FRAME Research)
Dr. Sofie Gielis (PXL-MAD School of Arts, FRAME Research)
Dr. Oliver Kohns (University of Luxemburg)
Dra. Hannelore Roth (University of Leuven)
Prof. dr. Pieter Vermeulen (University of Leuven)
Prof. dr. Esther Peeren (University of Amsterdam — Amsterdam Centre for Globalisation Studies)
ISSN 2506-798
Henry Roth Correspondence
No full textEntries include the typed transcripts of introductory correspondence from the Maine State Library and receipt of Roth\u27s book gift to the Maine Author Collection
Merktekens: Teksten van en over Silke Scheuermann
No full textMerktekens verzamelt teksten van en over de Duitse auteur Silke Scheuermann. Deze derde bundel uit de SCHRIFTUREN-reeks, die het werk van buitenlandse schrijvers voor een Nederlandstalig publiek wil ontsluiten, valt alweer niet enkel op door snedige teksten, maar ook door een eigenzinnig grafisch ontwerp, ditmaal door Oliver Ibsen. Schrijven is voor Scheuermann krassen, kerven, markeren en tatoeëren - en dat principe wordt ook in Merktekens radicaal doorgedrukt. Silke Scheuermann werd in 1973 geboren in Karlsruhe. Ze studeerde literatuur- en theaterwetenschappen in Frankfurt am Main en schrijft gedichten, romans, verhalen en essays. Vlijmscherp dissecteren haar teksten menselijke emoties en fantasmen. Daarbij komt een bevreemdend beeldend universum tot stand. Voor haar werk kreeg ze talloze prestigieuze prijzen en beurzen, waaronder de Hermann-Hesse-Literatur-Förderpreis, de Hölty-Preis für Lyrik en de Bertolt-Brecht-Preis. 'Een ingetoomde passie voor het reële, voor de levendige, zintuiglijke ervaring, jaagt haar verzen aan. Ze zijn als een met sneeuw bedekte vulkaan.' (Beatrix Langner) 'Silke Scheuermanns gedichten voeren de lezer terug naar het kantelpunt waarop hij zich opnieuw de mogelijkheden van het menszijn moet herinneren.
Merktekens: Teksten van en over Silke Scheuermann
No full textMerktekens verzamelt teksten van en over de Duitse auteur Silke Scheuermann. Deze derde bundel uit de SCHRIFTUREN-reeks, die het werk van buitenlandse schrijvers voor een Nederlandstalig publiek wil ontsluiten, valt alweer niet enkel op door snedige teksten, maar ook door een eigenzinnig grafisch ontwerp, ditmaal door Oliver Ibsen. Schrijven is voor Scheuermann krassen, kerven, markeren en tatoeëren - en dat principe wordt ook in Merktekens radicaal doorgedrukt. Silke Scheuermann werd in 1973 geboren in Karlsruhe. Ze studeerde literatuur- en theaterwetenschappen in Frankfurt am Main en schrijft gedichten, romans, verhalen en essays. Vlijmscherp dissecteren haar teksten menselijke emoties en fantasmen. Daarbij komt een bevreemdend beeldend universum tot stand. Voor haar werk kreeg ze talloze prestigieuze prijzen en beurzen, waaronder de Hermann-Hesse-Literatur-Förderpreis, de Hölty-Preis für Lyrik en de Bertolt-Brecht-Preis. 'Een ingetoomde passie voor het reële, voor de levendige, zintuiglijke ervaring, jaagt haar verzen aan. Ze zijn als een met sneeuw bedekte vulkaan.' (Beatrix Langner) 'Silke Scheuermanns gedichten voeren de lezer terug naar het kantelpunt waarop hij zich opnieuw de mogelijkheden van het menszijn moet herinneren.
The angular derivative problem for petals of one-parameter semigroups in the unit disk
No full textWe study the angular derivative problem for petals of one-parameter semigroups of holomorphic self-maps of the unit disk. For hyperbolic petals, we prove a necessary and sufficient condition for the conformality of the petal in terms of
the intrinsic hyperbolic geometry of the petal and the backward dynamics of the semigroup. For parabolic petals, we characterize conformality of the petal in terms of the asymptotic behaviour of the Koenigs function at the Denjoy–Wolff point
To be or not to be Sade: Philip Roth, "Sabbath's Theater" and Libertine Thought
No full textreservedIl presente elaborato si propone di indagare, all'interno dell'opera di Philip Roth, le forme e le ricorrenze tematiche legate al pensiero libertino. Sebbene si consideri anche la poetica dell’autore in generale, il focus viene posto sulle opere giudicate più rappresentative, in cui "l'argomento" libertinismo risulta essere più pregnante; un ruolo di primaria importanza in questo senso lo ricopre l'opera "Sabbath's Theatre" ("Il teatro di Sabbath"). Nonostante l'indagine sia di tipo tematico-comparatistico non si rifiuta una rigorosa ricostruzione storica della figura del libertino, soprattutto per meglio definirne il profilo e le caratteristiche; inoltre, la fondazione di un canone di autori "libertini" risulta fondamentale per far emergere ricorrenze tematico-stilistiche utili per meglio approcciare l'opera di Roth.This paper aims to investigate, within the great work of Philip Roth, the forms and thematic recurrences related to Libertine Thought. Although it also consider the poetics of the author in its wholeness, the focus is placed on the most representative works, in which "the subject" libertinism is more meaningful; a role of primary importance in this perspective is the novel "Sabbath’s Theatre". Despite the fact that the investigation is of a thematic-comparative nature, it does not elude a rigorous historical reconstruction of the figure of the libertine, especially to better define his profile and characteristics; moreover, the foundation of a canon of "libertine" authors is fundamental to bring out significative thematic-stylistic recurrences to better approach Roth’s work
Skaha Lake going to Oliver
No full textPhotograph consists of what appears to be a truckload of women and children. Note on the back of the photograph reads: "Skaha Lake Going to Oliver 24th May. Parmley's hard tired federal truck. Mrs Coulter (on running board) and Elmer Roth
Abstract 1917: CHD1 depletion leads to androgen-independent growth of prostate cancer cells lines and regulates the TGFβ system in an EZH2-dependent manner
No full textAbstract Introduction: Therapy of metastasized prostate cancer (PCA) largely depends on androgen deprivation therapy (ADT). Despite initial response, tumors inevitably reach castration resistance (CRPC), a stage at which chemotherapy and second-generation antiandrogens (e.g. Enzalutamide) represent the main therapeutic options. Acquired resistance to these drugs is an emerging problem, raising a need for new approaches. Deletion or mutation of the Chromodomain Helicase DNA binding protein 1 (CHD1) gene, encoding an ATP-dependent chromatin remodeler, is more prevalent in CRPC compared to earlier tumor stages. Therefore, we investigated the effects of CHD1 depletion in androgen-sensitive LNCaP cells. Experimental procedures: LNCaP cells were grown in media with either 10% fetal bovine serum (FBS), 10% charcoal-stripped serum (CSS) or 10% CSS plus 1nM testosterone. Growth was visualized by image-based cell cytometry. After 10 days of growth, RNA sequencing (RNA-seq) was performed to investigate changes in gene expression (between the different growth conditions with and without CHD1 depletion). Results were verified by qRT-PCR and Western blot. The identified treatment options were tested with small-molecule inhibitors in different concentrations. Finally, we performed chromatin immunoprecipitation followed by next-generation sequencing (ChIP-seq) in order to identify the epigenetic mechanisms underlying the differential regulation. Results: We identified a correlation between androgen-independent growth and CHD1 depletion which could be compensated by addition of 1 nM testosterone. Moreover, we identified CHD1-dependent regulation of Enhancer Of Zeste Homolog-2 (EZH2), which could be confirmed at the protein level. Treatment with 1 µM JQ-EZ (an EZH2 inhibitor) showed a stronger effect on the proliferation of CHD1-knockdown cells compared to controls. ChIP-seq and RNA-seq analysis helped to identify a subset of EZH2-bound genes depending on CHD1 knockdown and androgen deprivation. Among those genes, we identified the I-SMAD genes SMAD6 and SMAD7 which are regulators of TGFβ and BMP signaling to be upregulated after androgen-deprivation and downregulated with CHD1 knockdown. We also showed differential regulation of PMEPA1, a TGFβ-dependent inhibitor of PCA bone metastasis. Coherently, we found upregulation of mesenchymal markers such as CDH2, pointing towards a role in EMT. Conclusion: We identified a new regulatory mechanism for CRPC harboring a CHD1-deletion leading to a more mesenchymal state in an EZH2-dependent manner. First experiments with an EZH2 inhibitor in our system indicate a possible therapeutic use. CHD1 could hereby be used both as a biomarker for early metastasis as well as for therapeutic stratification. Citation Format: Simon J. Böcker, Simon J. Baumgart, Annabell Roth, Vijayalakshmi Kari, Steven A. Johnsen, Oliver Hahn. CHD1 depletion leads to androgen-independent growth of prostate cancer cells lines and regulates the TGFβ system in an EZH2-dependent manner [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1917
Joseph Roth and Slovenes
No full textŠtudija, napisana na podlagi primarnih in sekundarnih virov ter spominov, obravnava tista dela avstrijskega pisatelja Josepha Rotha, ki tematizirajo Slovence. V prvi vrsti gre za romana Radetzkyjeva koračnica (1932) in Kapucinska grobnica (1938), kjer so Slovenci kot osrednji literarni liki prvič vstopili v neslovensko svetovno književnost in to skozi velika vrata. V podporo adekvatnejši analizi literarnih likov upošteva tudi Rothove feljtone, objavljene v nemškem dnevniku Frankfurter Zeitung, kjer Roth poroča o južnih Slovanih, njihovi politiki in državi, ki jo označi za eno naslednic propadle Avstro-Ogrske na Balkanu. Avtorica se osredinja na Rothove slovenske like in njihov sprejem pri naših bralcih, pri čemer s primeri iz Rothovih feljtonov in siceršnjih avtorjevih zapisanih izjav dokazuje, da je Roth dobro poznal tako zgodovino kakor tudi zakonitosti literarnega ustvarjanja. Fikcija do neke mere temelji na resničnosti, vendar deluje po estetskih učinkih, ki z le-to niso vedno kompatibilni.The present study is based on primary and secondary literature as well as memoirs. It deals with those works by Austrian writer Joseph Roth that thematize Slovenians. First and foremost, these are the novels Radetzky March (1932) and The Emperor\u27s Tomb (1938). Slovenians are here central fictional characters, entered the non-Slovenian world literature of class for the first time, through the Great Gate. In support of the more adequate analysis of fictional characters of Slovenians, author also takes into account Roth\u27s feuilletons, published in the German daily Frankfurter Zeitung. Here he reports on South Slavs, their politics and the state, which he calls one of successor states in the Balkans of the decayed Habsburg Empire. The author focuses on Roth\u27s Slovenian fictional characters and their reception by Slovenian readers. By quoting his articles and few other statements on Slovenians she is about to prove that Roth knew very well both, the political history and the requests of creation of a work of fiction. Fiction is to some extent based on reality, though it works according to aesthetic effects that are not always compatible with it
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