1,016 research outputs found
Heterocyclic Chemistry – Old Science or the Forefront of Chemistry?
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Oliver Reiser studied chemistry at the Universities of Hamburg, Jerusalem and Los Angeles (UCLA) and earned his Ph.D. degree from the University of Hamburg (Prof. Armin de Meijere) in 1989. After postdoctoral stays at IBM Research Center (Dr. Robert D. Miller) and Harvard University (Prof. David A. Evans), he started his independent research in 1992 at the University of Göttingen. In 1996, he moved to the University of Stuttgart as an Associate Professor and in 1997, to the University of Regensburg as Professor of Chemistry. His research group specializes in catalysis starting from renewable resources such as furans and pyrroles toward fine chemicals, natural products and drugs. He is currently serving as President of the International Society of Heterocyclic Chemistry.</jats:p
Synthesis and exploration of chiral aza-bis(oxazolines) and organocatalysts in asymmetric reactions
No full textAza-bis(oxazolines) (azabox) were introduced by our group in 20001 as structural hybrids of bis(oxazolines) and aza-semicorrins. The attractive features of these ligands are their facile attachment to organic and inorganic supports through alkylation of the central nitrogen, thus, arriving at recyclable catalysts, and the higher electron density than the corresponding bis-(oxazolines), which has been found to be advantages for some reactions, for example in Co catalyzed conjugate reduction of alpha, beta-unsaturated carbonyl compounds or in Pd catalyzed allylations.
In order to further utilize the great potential of azabox ligands, their immobilization on various polymeric supports (MeOPEG, Tentagel, Polystyrene, Dendrimer, Fluorous metrials, etc)26 via click reaction was studied, offering both an easy way to recover precious chiral catalysts and improving on reactions through unusual solvation effects. The obtained yield and enantioselectivities were equal or comparable to the non-immobilized ligands
Enantioselective synthesis of (-)-Paeonilide
No full textIt was aim of this work to synthesize the unnatural enantiomer (-)-Paeonilide in an enantioselective way. The natural counterpart of this monoterpenoid showed an inhibitory effect against the thrombozyte aggregation induced by PAF. Starting from the achiral 3-furoic acid, stereoinformation was introduced by a copper(I) catalyzed cyclopropanation, utilizing a chiral bis(oxazoline)-ligand. This precursor was transformed to the furo-lactone core skeleton of the target molecule. Subsequent transformations led to (-)-Paeonilide
Reiser, Infant (Death, 1908-12-20)
No full textAddress: 1692 Queen City Ave.Age at death: Stillbirth312/Pg 148/1908/MW/City/Oliver P. Cor. Cor./P. Rebold & Sons/St. Marys Cem.Original record filed in drawer labeled 'REIK-REMY'
Palladium-Catalyzed Coupling Reactions for the Stereoselective Synthesis of Tri- and Tetrasubstituted Alkenes
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Heterocyclic Chemistry – A Mature Area in Its Infancy!
No full textFor a long time, the construction of heterocycles reliably forged a carbonheteroatom bond by the interaction between a nucleophilic heteroatom and an electrophilic C=X or C-X-moiety. This concept has been greatly expanded with the development of many synthetic methods that seemingly defy standard reactivities in molecules. The collection of almost 100 articles in the special issues of Eur. J. Org. Chem. and Asian Org. Chem. impressively attest to the creativity and efforts that are going on in this field: mature, but still young at heart
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